Achievements

Original paper Amino acid–dependent TSC2 dephosphorylation by lysosome–PP2A regulates mTORC1 signaling transduction

Life Science Alliance.， 2025； vol8 no11：e202503206

DOI:10.26508/lsa.202503206

Takanori Nakamura , Shigeyuki Nada , Masaki Matsumoto , Nuha Loling Othman , Hidetaka Kosako , Kazuki Ikeda , Naohiko Koshikawa , Junya Masumoto , Tatsuya Sawasaki , Mutsuhiro Takekawa , Takashi Suzuki , Masato Okada

Original paper Dnmt1 determines bone length by regulating energy metabolism of growth plate chondrocytes

Nat Commun..， 2025； 16：9452

DOI:10.1038/s41467-025-65145-9

Yanagihara Y, Takahashi M, Izumi Y, Kinoshita T, Takao M, Bamba T, Imai Y.

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

International Journal of Molecular Sciences.， 2025； 24 (12)：10186

DOI:10.3390/ijms241210186

Takashi Saitou, Takeshi Imamura

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

International Journal of Molecular Sciences.， 2025； 24 (12)：10186

DOI:10.3390/ijms241210186

Takashi Saitou, Takeshi Imamura

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

International Journal of Molecular Sciences.， 2025； 24 (12)：10186

DOI:10.3390/ijms241210186

Takashi Saitou, Takeshi Imamura

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

International Journal of Molecular Sciences.， 2025； 24 (12)：10186

DOI:10.3390/ijms241210186

Takashi Saitou, Takeshi Imamura

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

International Journal of Molecular Sciences.， 2025； 24 (12)：10186

DOI:10.3390/ijms241210186

Takashi Saitou, Takeshi Imamura

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

International Journal of Molecular Sciences.， 2025； 24 (12)：10186

DOI:10.3390/ijms241210186

Takashi Saitou, Takeshi Imamura

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

International Journal of Molecular Sciences.， 2025； 24 (12)：10186

DOI:10.3390/ijms241210186

Takashi Saitou, Takeshi Imamura

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

International Journal of Molecular Sciences.， 2025； 24 (12)：10186

DOI:10.3390/ijms241210186

Takashi Saitou, Takeshi Imamura

Original paper CTHRC1 promotes bone metastasis in prostate cancer

Int J Cancer..， 2025； 157(11)：2399-2412

DOI:10.1002/ijc.70012

Sawada Y, Kikugawa T, Onishi T, Arai O, Iio H, Miura N, Yoshida S, Ikedo A, Yanagihara Y, Saeki N, Sakakibara I, Győrffy B, Kishida T, Okubo Y, Nakamura Y, Sato S, Miyagi Y, Saika T, Imai Y.

Original paper Aromatase in adipose tissue exerts an osteoprotective function in male mice via phosphate regulation

J Bone Miner Res..， 2025； 1：zjaf129

DOI:10.1093/jbmr/zjaf129

Ikedo A, Yamashita M, Hoshino M, Okuno Y, Koike M, Uga M, Tanifuji K, Segawa H, Fukumoto S, Imai Y.

Original paper Diagnosis of Leptomeningeal Disease in Diffuse Midline Gliomas by Detection of H3F3A K27M Mutation in Circulating Tumor DNA of Cerebrospinal Fluid.

Pediatr Blood Cancer..， 2025； 72(4)：e31535

DOI:10.1002/pbc.31535

Satoshi Shibuma, Jotaro On, Manabu Natsumeda, Akihide Koyama, Haruhiko Takahashi, Jun Watanabe, Masaki Mitobe, Satoshi Nakata, Yuki Tanaka, Yoshihiro Tsukamoto, Masayasu Okada, Junichi Yoshimura, Mari Tada, Hiroshi Shimizu, Soichi Oya, Junko Murai, Kouichirou Okamoto, Hiroyuki Kawashima, Akiyoshi Kakita, Makoto Oishi

Original paper SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis.

Mol Cell..， 2025； 85(5)：894-912

DOI:10.1016/j.molcel.2025.01.008

Akane Ogawa, Keiichi Izumikawa, Sota Tate, Sho Isoyama, Masaru Mori, Kohei Fujiwara, Soyoka Watanabe, Takayuki Ohga, Ukhyun Jo, Daiki Taniyama, Shojiro Kitajima, Soichiro Tanaka, Hiroshi Onji, Shun-Ichiro Kageyama, Gaku Yamamoto, Hitoshi Saito, Tomoko Yamamori Morita, Masayasu Okada, Manabu Natsumeda, Masami Nagahama, Junya Kobayashi, Akihiro Ohashi, Hiroyuki Sasanuma, Shigeki Higashiyama, Shingo Dan, Yves Pommier, Junko Murai

Original paper PARP Inhibitors in Genitourinary Cancer: A New Paradigm Beyond Prostate Cancer.

Int. j. urol..， 2025； 32(9)：1091-1101

DOI:10.1111/iju.70100

Yohei Okuda, Taigo Kato, Yu Ishizuya, Takuji Hayashi, Yoshiyuki Yamamoto, Koji Hatano, Atsunari Kawashima, Junko Murai, Norio Nonomura

Original paper KLHL5 Contributes to Colorectal Cancer Cell Survival by Promoting Cell Cycle Progression and Suppressing Apoptotic Cell Death

Cancer Sci..， 2025； 116(9)：2444-2456

DOI:10.1111/cas.70108

Kyosuke Habu, Yosuke Matsuoka, Hiromi Hiyoshi, Jun Nakayama, Katsuya Watanabe, Sota Tate, Tomohisa Sakaue, Junko Murai, Konomu Uno, Hirotada Nishie, Eiji Kubota, Hiromi Kataoka, Takashi Joh, Yuji Watanabe, Taro Oshikiri, Shigeki Higashiyama

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

International Journal of Molecular Sciences.， 2024； 24 (12)：10186

DOI:10.3390/ijms241210186

Takashi Saitou, Takeshi Imamura

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

International Journal of Molecular Sciences.， 2024； 24 (12)：10186

DOI:10.3390/ijms241210186

Takashi Saitou, Takeshi Imamura

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

International Journal of Molecular Sciences.， 2024； 24 (12)：10186

DOI:10.3390/ijms241210186

Takashi Saitou, Takeshi Imamura

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

International Journal of Molecular Sciences.， 2024； 24 (12)：10186

DOI:10.3390/ijms241210186

Takashi Saitou, Takeshi Imamura

ACHIEVEMENTS

SEARCH ACHIEVEMENTS

Original paper Amino acid–dependent TSC2 dephosphorylation by lysosome–PP2A regulates mTORC1 signaling transduction

Original paper Dnmt1 determines bone length by regulating energy metabolism of growth plate chondrocytes

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

Original paper CTHRC1 promotes bone metastasis in prostate cancer

Original paper Aromatase in adipose tissue exerts an osteoprotective function in male mice via phosphate regulation

Original paper Diagnosis of Leptomeningeal Disease in Diffuse Midline Gliomas by Detection of H3F3A K27M Mutation in Circulating Tumor DNA of Cerebrospinal Fluid.

Original paper SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis.

Original paper PARP Inhibitors in Genitourinary Cancer: A New Paradigm Beyond Prostate Cancer.

Original paper KLHL5 Contributes to Colorectal Cancer Cell Survival by Promoting Cell Cycle Progression and Suppressing Apoptotic Cell Death

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution