研究業績｜愛媛大学プロテオサイエンスセンター

英文原著 The Need for Novel Asexual Blood-Stage Malaria Vaccine Candidates for Plasmodium falciparum.

Biomolecules..， 2024； 1：

DOI:doi: 10.3390/biom14010100.

Takashima E, Otsuki H, Morita M, Ito D, Nagaoka H, Yuguchi T, Hassan I, Tsuboi T.

英文原著 Autoantibodies inhibit Plasmodium falciparum growth and are associated with protection from clinical malaria.

Immunity..， 2024； 1：1769-1779

DOI:doi: 10.1016/j.immuni.2024.05.024.

Hagadorn KA, Peterson ME, Kole H, Scott B, Skinner J, Diouf A, Takashima E, Ongoiba A, Doumbo S, Doumtabe D, Li S, Sekar P, Yan M, Zhu C, Nagaoka H, Kanoi BN, Li QZ, Long C, Long EO, Kayentao K, Jenks SA, Sanz I, Tsuboi T, Traore B, Bolland S, Miura K, Crompton PD, Hopp CS.

英文原著 (English) Direct Binding of Synaptopodin 2-Like Protein to Alpha-Actinin Contributes to Actin Bundle Formation in Cardiomyocytes.

(English) Cells..， 2024； (English) 1：

DOI:(English) doi: 10.3390/cells13161373.

(English) Yamada H, Osaka H, Tatsumi N, Araki M, Abe T, Kaihara K, Takahashi K, Takashima E, Uchihashi T, Naruse K, Takei K.

英文原著 Ultrastructural expansion microscopy (U-ExM) visualization of malaria parasite dense granules using RESA as a representative marker protein,

Parasitology International.， 2024； 1：

DOI:DOI: 10.1016/j.parint.2024.103023 (in press).

Fukumoto J, Tsuboi T, Takashima E

英文原著 (English) A systems serology approach to identifying key antibody correlates of protection from cerebral malaria in Malawian children.

(English) BMC Med..， 2024； (English) 1：

DOI:(English) doi: 10.1186/s12916-024-03604-8.

Walker IS, Dini S, Aitken EH, Damelang T, Hasang W, Alemu A, Jensen ATR, Rambhatla JS, Opi DH, Duffy MF, Takashima E, Harawa V, Tsuboi T, Simpson JA, Mandala W, Taylor TE, Seydel KB, Chung AW, Rogerson SJ.

英文原著 RH5: rationally-designed malaria vaccine antigen improving efficacy

Trends Parasitol.， 2024； 1：870-872

DOI:doi: 10.1016/j.pt.2024.09.001.

Takashima E, Tsuboi T

英文原著 β-Nicotinamide mononucleotide preserves muscle strength in septic male mice

Sci Rep..， 2026； 16：8905

DOI:10.1038/s41598-026-43172-w

Saida M, Saeki N, Sakai H, Iwanami J, Yokoyama A, Sawatsubashi S, Kanagawa M, Sato N, Imai Y.

英文原著 Dissecting Hhip1 Function In Vivo Using a Conditional Knockout Mouse Model

Acta Histochem Cytochem..， 2025； 58(6)：187-198

DOI:10.1267/ahc.25-00028

Haraguchi R, Kitazawa R, Yanagihara Y, Imai Y, Kitazawa S.

英文原著 Biotin binder (BB) and BB-LucYY5: A sensitive and quantitative platform for biotin-labelled protein analysis

Biochemical and Biophysical Research Communications.， 2025； 796：153125

DOI:10.1016/j.bbrc.2025.153125

Mana Hamada, Suzuno Hirano, Kohdai Yamada, Soh Tokunaga, Tatsuhiko Ozawa, Hiroyuki Takeda, Mayumi Tachibana, Motomi Torii, Akira Nozawa, Tatsuya Sawasaki

英文原著 Evaluation of Malaria Parasite Transmission Competency Using a Nanozyme-Based Immunodiagnostic Targeting Female Gamete Antigen Release

ACS Nano.， 2025； 19：36419−36434

DOI:10.1021/acsnano.5c10298

Tabasom Haghighi, Adrian Najer*, Marta Broto, Farah A. Dahalan, Alisje Churchyard, Sabrina Yahiya, Mufuliat T. Famodimu, Mark Tunnicliff, Aida Abdelwahed, Mayumi Tachibana, Tomoko Ishino, Yaw Aniweh, Gordon A. Awandare, Almahamoudou Mahamar, Leen N. Vanheer, Teun Bousema, Chris Drakeley, Alassane Dicko, William Stone, Jake Baum*, Molly M. Stevens*

英文原著 Enhancing Global Science Education at Ehime University for the Next Generation

日本科学教育学会年会論文集.， 2025； 49：629-632

DOI:10.14935/jssep.49.0_629

Aki KATO, Richard CULLETON, Ruth VERGIN

英文原著 CDH11 contributes to bladder cancer progression via regulation of mitochondrial energy metabolism

Cancer Med..， 2025； 14(22)：e71399

DOI:10.1002/cam4.71399

Arai O, Yanagihara Y, Arai H, Watanabe R, Miura N, Kikugawa T, Saika T, Imai Y.

英文原著 Estrogen signaling in PDGFRα+ cells positively regulates cortical bone metabolism via IGFBP5 in female mice

JBMR Plus..， 2025； 10(1)：ziaf178

DOI:10.1093/jbmrpl/ziaf178

Ikedo A, Aoki R, Sakai H, Saeki N, Yanagihara Y, Moody J, Kojima M, Kouno T, Ando Y, Hino K, Kinoshita T, Carninci P, Shin JW, Hon CC, Uezumi A, Kamei Y, Imai Y.

英文原著 Claudin 5-binding small molecule transiently opens the blood-brain barrier and safely enhances brain drug delivery

J Control Release.， 2025； 388：114314

DOI:10.1016/j.jconrel.2025.114314

Saito Inoue, Keisuke Shirakura, Atsuya Shirono, Jumpei Taguchi, Yoshiki Ikeda, Satomi Tomita, Risa Funatsu, Kosuke Muraoka, Yosuke Hashimoto, Keisuke Tachibana, Nobumasa Hino, Takefumi Doi, Yui Ikemi, Kazuto Nunomura, Bangzhong Lin, Shinsaku Nakagawa, Kazutake Tsujikawa, Shota Tanaka, Masanori Obana, Yasushi Fujio, Takamitsu Hosoya, Hiroyuki Takeda, Masuo Kondoh, Yoshiaki Okada

英文原著 Size-selective permeation-enhancing modulation of the tight junction by receptor-binding domains of Clostridium perfringens enterotoxin and Clostridium perfringens iota-toxin

Tissue Barriers.， 2025； 13：2459963

DOI:10.1080/21688370.2025.2459963

Keisuke Tachibana, Sayaka Sugimura, Shuko Sakimura, Lin Bai, Hiroshi Aoyama, Hiroyuki Takeda, Yuki Niwa, Masahiro Nagahama, Masuo Kondoh

英文原著 Structural basis of the hepatitis B virus X protein in complex with DDB1

Proc Natl Acad Sci U S A.， 2025； 122：e2421325122

DOI:10.1073/pnas.2421325122

Hiroki Tanaka, Joao Diogo Dias, Basile Jay, Shunsuke Kita, Mina Sasaki, Hiroyuki Takeda, Naoki Kishimoto, Shunsuke Sasaki, Shogo Misumi 5, Masashi Mizokami, Christine Neuveut, Takashi Sumikama, Mikihiro Shibata, Katsumi Maenaka, Shinichi Machida

英文原著 Caspase-mediated cleavage of a scaffold protein, MPRIP, yields a truncated form that is involved in repetitive bleb formation

FEBS Journal.， 2025； 292：2287-2305

DOI:10.1111/febs.17422

Kazuhiro Sakamaki, Naohisa Sakamoto, Yuki Tsujimura, Takahiro Iwasaki, Takuma Kawamura, Jun Nakabayashi, Rhea S. D'Souza, Arooma Jannat, Ken-ichiro Takeshima, Hiroyuki Takeda, Koji Koyamada, Hideo Yokota

英文原著 Machine learning-based insights into circulating autoantibody dynamics and treatment outcomes in patients with NSCLC receiving immune checkpoint inhibitors.

Front Immunol..， 2025； 16：1666030

DOI:10.3389/fimmu.2025.1666030.

Wei F, Takeda H, Azuma K, Nakahara Y, Igarashi Y, Murotani K, Saito H, Murakami S, Kondo T, Kouro T, Himuro H, Tsuji K, Komahashi M, Sawasaki T, Sasada T.

英文原著 In-cell proximity target validation methods for heterobifunctional molecules with CRBN- or VHL-binder using AirID.

Commun Biol..， 2025； 8：1323

DOI:10.1038/s42003-025-08761-x.

Yamada K, Yamanaka S, Yamakoshi H, Kohyama A, Iwabuchi Y, Kosako H, Sawasaki T.

英文原著 ZFP36L1 and L2 as novel antiviral factors for Crimean-Congo hemorrhagic fever virus via interaction with viral nucleoprotein.

J Biol Chem..， 2025； 301：110545

DOI:10.1016/j.jbc.2025.110545.

Hirano M, Nochi K, Matsugi M, Furukawa C, Takeda H, Sakurai Y, Kurosaki Y, Sawasaki T, Yasuda J, Takahashi H, Yoshii K.

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