研究業績｜愛媛大学プロテオサイエンスセンター

英文原著 METTL18 is Required for Developmental, Metabolic, and Endocrine Regulation of Mammalian Growth

FASEB J..， 2026； 40(17)：e72224

DOI:10.1096/fj.202600392R

Kasai F, Kim JD, Kako K, Muromachi N, Saito T, Yuan Y, Mizukami H, Kishikawa N, Nakamura K, Motomura K, Daitoku H, Imai Y, Sekiguchi S, Horiguchi K, Narumi S, Yamada M, Fukamizu A.

英文原著 Potential Targets of Naturally Acquired Plasmodium vivax Transmission – Reducing Antibodies

Journal of Infection.， 2026； 93(3)：106833

DOI:10.1016/j.jinf.2026.106833

Rojrung R, Thongpoon S, Yuguchi T, Roobsoong W, Nagaoka H, Nguitragool W, Kanoi BN, Chotirat S, Tachibana M, Cui L, Ishino T, Miura K, Tsuboi T, Sattabongkot J, Takashima E.

英文原著 Corisin induces proteostasis stress to drive epithelial injury and pulmonary fibrosis.

Nat Commun..， 2026； 17：8486

DOI:10.1038/s41467-026-76162-7

Fujimoto H, Yasuma T, D'Alessandro-Gabazza CN, Toda M, Nishihama K, Takeshita A, Fridman D'Alessandro V, Tomaru A, Saiki H, Okano T, Kogue Y, Anoh T, Alhawsawi MAB, Abdel-Hamid AM, Imai B, Fields CJ, Teofanovic J, Leistikow K, Ono R, Nosaka T, Yamazaki H, Yamakawa D, Bando YK, Sugihara F, Kikuta J, Kataoka K, Kondoh Y, Sakaue T, Takeda H, Yano Y, Hataji O, Cann I, Kobayashi T, Gabazza EC.

英文原著 Alkyne Two-Phase Strategy: Rapid Generation of TK-285-Derived PROTACs as BRD4 Degraders.

J Med Chem..， 2026； 69：8388-8416

DOI:10.1021/acs.jmedchem.5c03771

Yamakoshi H, Watanabe R, Segawa R, Ishihara R, Tachibana R, Kudo G, Nagasawa S, Yamanaka S, Ito A, Takeda H, Sawasaki T, Yoshino R, Hirokawa T, Doi T, Hirasawa N, Iwabuchi Y.

英文原著 Design of Analytical Methods for Protein Adsorption Characteristics at Material Interfaces.

Langmuir.， 2026； 42：17363-17374

DOI:10.1021/acs.langmuir.6c00943

Tanaka K, Nakano Y, Suganuma M, Matsumoto K, Hasegawa T, Nakahara M, Suto K, Ejima D, Imoarai T, Takeda H.

英文原著 A lysine-free REC tag system for proximity-biotinylation applications.

Sci Rep..， 2026； 16：4846

DOI:10.1038/s41598-026-35323-w

Tokunaga S, Nagaoka H, Ozawa T, Yamada K, Takeda H, Fujisaki H, Hamada M, Soga F, Kishi H, Takashima E, Sawasaki T.

英文原著 Screening and Engineering of Ancestral Sortase Es That Enable High-Fidelity Enzyme Design with Activity Trade-Off.

Bioconjug Chem..， 2026； 37：341-350

DOI:10.1021/acs.bioconjchem.5c00576

Koshiba R, Chisuga T, Fujinami D, Takeda H, Nakano S.

英文原著 Face Mask-Wearing Behaviour Among Young Adults During and After the COVID-19 Epidemic in China

Asia Pac J Public Health.， 2026； 38(4)：332-335

DOI:10.1177/10105395261433224

Tao Z, Fang R, Ma T, Jiang W, Xia H, Culleton R, Jiao Y.

英文原著 Saptiotemporal regulation of MKK4 dictates switch-like JNK activation and binary cell-fate decisions.

Nature Communications.， 2026； 17：1-18

DOI:10.1038/s41467-025-67943-7

Hisashi Moriizumi, Takanori Nakamura, Yuji Kubota, Ryosuke Hiranuma, Youngmin Cho, Toru Kawanishi, Hiroyuki Takeda, Takashi Suzuki, Mutsuhiro Takekawa

英文原著 An autopsy case of multiple liver metastases from minute pancreatic acinar cell carcinoma clinically diagnosed as primary hepatic acinar cell carcinoma.

Clinical Journal of Gastroenterology..， 2026； 19：413-422

DOI:10.1007/s12328-026-02283-7

Okujima, Y., Tada, F., Murakami, H., Miyaoka, H., Kurata, M., & Masumoto, J

英文原著 Macrophage accumulation on the injured pulmonary surface promotes intrathoracic adhesions.

Signal Transduction and Targeted Therapy..， 2026； 11：1-3

DOI:10.1038/s41392-026-02762-w

Mori, Y., Sakaue, T., Okazaki, M., Kurata, M., & Izutani, H.

英文原著 Novel biodegradable device for transcatheter closure of atrial septal defects.

Scientific Reports..， 2026； 16：1-9

DOI:10.1038/s41598-026-48868-7

Kurobe, H., Sakaue, T., Hirata, Y., Moritani, T., Kurata, M., Higaki, T., & Shinoka, T.

英文原著 Caldesmon-1-mediated actin dynamics is essential for osteogenic differentiation of aortic valve interstitial cells.

Scientific Reports.， 2026； 16：1-16

DOI:10.1038/s41598-026-39938-x

Komoda, M., Sakaue, T., Nakao, Y., Sakamoto, H., Fukunishi, T., Higaki, T., Aono, J., Kurobe, H., Kurata, M., Nishimura, T., & Izutani, H.

英文原著 Diagnostic performance of kinetic parameters of ultrafast breast MRI and their associations with immunohistopathological findings of breast carcinoma.

Scientific Reports..， 2026； 16：1-14

DOI:10.1038/s41598-026-55998-5

Kobayashi, A., Matsuda, M., Okada, K., Matsuda, T., Ebihara, R., Ochi, H., Kawaguchi, N., Shiraishi, Y., Takimoto, Y., Ihara, Y., Kamei, Y., Kurata, M., Kitazawa, R., & Kido, T.

英文原著 Spatial transcriptomics of urothelial carcinoma with basal/squamous differentiation identifies Galectin-7 as a specific marker of squamous lineage commitment. Discover.

Discov Oncol.， 2026； 17：722

DOI:10.1007/s12672-026-04927-z

Haga, S., Watanabe, R., Kurata, M., Miura, N., Liu, S., Kikugawa, T., Kitazawa, R., Mogi, M., & Saika, T.

英文原著 Uhrf1 in PDGFRα-lineage cells regulates osteophyte formation in osteoarthritis

iScience..， 2026； 29(8)：116927

DOI:10.1016/j.isci.2026.116927

Jono A, Yanagihara Y, Sakai H, Saeki N, Kutsuna T, Kinoshita T, Uezumi A, Takao M, Imai Y.

英文原著 Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease

Nat Genet..， 2026； 58(7)：1530-1545

DOI:10.1038/s41588-026-02640-9

Chai RC, Lundberg M, Freudenthal B, Smith JT, Boughton AP, Zhang Y, Flynn KA, Frysz M, Corr AP, Khoo WH, Komla-Ebri D, Dack MRG, Guilfoyle SE, Logan JG, Butterfield NC, Leitch VD, Pollard AS, Mäkitie RE, Bradford N, Ramos-Mucci L, Vilas-Zornoza A, Chen Y, Yip RKH, Er J, Tan SZ, McDonald MM, Youlten SE, Sergio CM, Castro-Martinez A, Young SG, Skorokhodova E, Evans DM, Powell JE, de Leeuw CA, Ewing AD, Eisman JA, Blank RD, Phan TG; International Federation of Musculoskeletal Research Societies (IFMRS) Big Data Working Group; Lagendijk AK, Hawkins ED, Oh HL, McIntyre RE, Hessel EM, Taylor-King JP, Baldock PA, Duncan EL, Williams GR, Bassett JHD, Croucher PI, Kemp JP.

英文原著 S100A4-TLR4-TGF-β axis as a therapeutic target for Dupuytren’s contracture in diabetic patients

Cell Death Discov..， 2026； 12：310

DOI:10.1038/s41420-026-03167-y

Kato K, Komura S, Yanagihara Y, Saeki N, Goto A, Maki R, Hirose H, Hirakawa A, Imai Y, Akiyama H.

英文原著 Ldha Regulates Osteosarcoma Lung Metastasis through Hedgehog Signaling

Cancer Res Commun..， 2026； 6(6)：1495-1508

DOI:10.1158/2767-9764.CRC-25-0163

Maki R, Komura S, Nagano A, Niwa A, Tomita H, Imai Y, Akiyama H.

英文原著 A pleckstrin homology domain protein is involved in crystalloid formation in Plasmodium ookinetes and affects the maturation of infective sporozoites

oop Logo Frontiers in Cellular and Infection Microbiology.， 2026； 16：2026

DOI:10.3389/fcimb.2026.1777159

Mayumi Tachibana, Naoaki Shinzawa, Minami Baba, Motomi Torii, Richard Culleton, Tomoko Ishino

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