Achievements

Original paper The H3K9 demethylase plant homeodomain finger protein 2 regulates interleukin 4 production in CD4+ T cells

Cytokine.， 2024； 175：156506

DOI:10.1016/j.cyto.2024.156506

Arakawa Y, Tano Y, Fujii M, Imai Y, Norimatsu Y, Yasukawa M, Watanabe M, Yamada T.

Original paper The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells

Communications Biology.， 2023； 6：65

DOI:10.1038/s42003-023-04444-7

Christopher Noyes, Shunsuke Kitajima, Fengkai Li, Yusuke Suita, Saradha Miriyala, Shakson Isaac, Nagib Ahsan, Erik Knelson, Amir Vajdi, Tetsuo Tani, Tran C. Thai, Derek Xu, Junko Murai, Nikos Tapinos, Chiaki Takahashi, David A. Barbie, Mamiko Yajima*

Original paper BRCAness, Homologous Recombination Deficiencies, and Synthetic Lethality

Cancer Research.， 2023； 83(8)：1173-1174

DOI:10.1158/0008-5472.can-23-0628

Junko Murai, Yves Pommier*

Original paper Schlafen 11 (SLFN11) kills cancer cells undergoing unscheduled re-replication

Molecular Cancer Therapeutics.， 2023； 22(8)：985-995

DOI:10.1158/1535-7163.MCT-22-0552

Junko Murai*, Michele Ceribelli, Haiqing Fu, Christophe E. Redon, Ukhyun Jo, Yasuhisa Murai, Mirit I. Aladjem, Craig J. Thomas, Yves Pommier*

Original paper SLFN11 is a BRCA independent biomarker for the response to platinum-based chemotherapy in high-grade serous ovarian cancer and clear cell ovarian carcinoma.

Molecular Cancer Therapeutics.， 2023； 23(1)：106–116

DOI:10.1158/1535-7163.MCT-23-0257

Hidehiko Akashi, Nozomi Yachida, Haruka Ueda, Manako Yamaguchi, Kaoru Yamawaki, Ryo Tamura, Kazuaki Suda, Tatsuya Ishiguro, Sosuke Adachi, Yoshikazu Nagase, Yutaka Ueda, Masashi Ueda, Kaoru Abiko, Masahiro Kagabu, Tsukasa Baba, Hirofumi Nakaoka, Takayuki Enomoto, Junko Murai*, Kosuke Yoshihara*

Original paper Aberrant accumulation of NIK promotes tumor growth by dysregulating translation and post-translational modifications in breast cancer.

Cancer Cell International.， 2023； 23：57

DOI:10.1186/s12935-023-02904-y

Hayashi Y, Nakayama J, Yamamoto M, Maekawa M, Watanabe S, Higashiyama S, Inoue JI, Yamamoto Y, Semba K

Original paper Metabolic clogging of mannose triggers genomic instability via dNTP loss in human cancer cells

eLife.， 2023； 12：e83870

DOI:10.7554/eLife.83870

Harada Y, Mizote Y, Suzuki T, Nishida M, Hiratsuka T, Ueda A, Imagawa Y, Maeda K, Ohkawa Y, Murai M, Freeze H. H, Miyoshi E, Higashiyama S, Udono U, Dohmae N, Tahara H, Taniguchi N.

Original paper SPOP is essential for DNA replication licensing through maintaining translation of CDT1 and CDC6 in HaCaT cells.

Biochemical and Biophysical Research Communications.， 2023； 651(9)：30-38

DOI:10.1016/j.bbrc.2023.02.012

Sanada S, Maekawa M, Tate S, Nakaoka H, Fujisawa Y, Sayama K, Higashiyama S.

Original paper BCL6B Contributes to Ocular Vascular Diseases via Notch Signal Silencing

Arteriosclerosis, Thrombosis, and Vascular Biology.， 2023； 43：927-942

DOI:10.1161/ATVBAHA.123.318987

Tanaka M, Nakamura S, Sakaue T, Yamamoto T, Maekawa M, Nishinaka A, Yasuda H, Yunoki K, Sato Y, Sawa M, Yoshino K, Shimazawa M, Hatano M, Tokuhisa T, Higashiyama S, Hara H.

Original paper Human TMEM2 is not a catalytic hyaluronidase, but a regulator of hyaluronan metabolism via HYBID (KIAA1199/CEMIP) and HAS2 expression.

Journal of Biological Chemistry.， 2023； 299：104826

DOI:10.1016/j.jbc.2023.104826

Sato S, Miyazaki M, Fukuda S, Mizutani Y, Mizukami Y, Higashiyama S, Inoue S

Original paper Reply: Low-Grade Inflammation: A Familiar Factor in Cardiovascular Diseases

JACC: Basic to Translational Science.， 2023； 8 (11)：1476

DOI:10.1016/j.jacbts.2023.09.009

Sakaue T and Izutani H

Original paper Wnt activation disturbs cell competition and causes diffuse invasion of transformed cells through NF-κB-MMP21 pathway

Nature Communications.， 2023； 14：7048

DOI:10.1038/s41467-023-42774-6

Nakai K, Lin H, Yamano S, Tanaka S, Kitamoto S, Saitoh H, Sakuma K, Kurauchi J, Akter E, Konno M, Ishibashi K, Kamata R, Ohashi A, Koseki J, Takahashi H, Yokoyama H, Shiraki Y, Enomoto A, Abe S, Hayakawa Y, Ushiku T, Mutoh M, Fujita Y, Kon S.

Original paper Utility of synthetic MRI in predicting pathological complete response of various breast cancer subtypes prior to neoadjuvant chemotherapy

Clin Radiol..， 2022； 2022 Aug 30：S0009-9260(22)00328-2

DOI:10.1016/j.crad.2022.06.019

M.Matsuda, N.Fukuyama, T.Matsuda, S.Kikuchi, Y.Shiraishi, Y.Takimoto, Y.Kamei, M.Kurata, R.Kitazawa, T.Kido

Original paper Triple-negative breast cancer on contrast-enhanced MRI and synthetic MRI: A comparison with non-triple-negative breast carcinoma

Eur J Radiol.， 2022； Sep;142：109838

DOI:10.1016/j.ejrad.2021.109838

Megumi Matsuda, Takaharu Tsuda, Rui Ebihara, Wataru Toshimori, Kanako Okada, Shiori Takeda, Aya Okumura, Yasuhiro Shiraishi, Hiroshi Suekuni, Yoshiaki Kamei, Mie Kurata, Riko Kitazawa, Teruhito Mochizuki, Teruhito Kido

Original paper Synthesis and photophysical properties of a new push–pull pyrene dye with green-to-far-red emission and its application to human cellular and skin tissue imaging

Journal of Materials Chemistry B.， 2022； 10：1641-1649

DOI:10.1039/D1TB02728J

Kazuki Inoue, Ryosuke Kawakami, Masamoto Murakami, Taku Nakayama, Shinkuro Yamamoto, Keiji Inoue, Teruko Tsuda, Koji Sayama, Takeshi Imamura, Daisuke Kaneno, Shingo Hadano, Shigeru Watanabe and Yosuke Niko

Original paper TGFβ selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial–mesenchymal transition

Molecular Oncology.， 2022； 16(12)：2330-2354

DOI:10.1002/1878-0261.13215

Yutaro Tsubakihara, Yae Ohata, Yukari Okita, Shady Younis, Jens Eriksson, Mikael E. Sellin, Jiang Ren, Peter ten Dijke, Kohei Miyazono, Atsuhiko Hikita, Takeshi Imamura, Mitsuyasu Kato, Carl-Henrik Heldin, Aristidis Moustakas

Original paper Tumor-targeted fluorescence labeling systems for cancer diagnosis and treatment

Cancer Science.， 2022； 113(6)：1919-1929

DOI:10.1111/cas.15369

Hiroshi Tazawa, Kunitoshi Shigeyasu, Kazuhiro Noma, Shunsuke Kagawa, Fuminori Sakurai, Hiroyuki Mizuguchi, Hisataka Kobayashi, Takeshi Imamura, Toshiyoshi Fujiwara

Original paper Aryl hydrocarbon receptor signals in epithelial cells govern the recruitment and location of Helios+ Tregs in the gut

Cell Reports.， 2022； 39(6)：110773

DOI:10.1016/j.celrep.2022.110773

Yusuke Yoshimatsu, Tomohisa Sujino, Kentaro Miyamoto, Yosuke Harada, Shun Tanemoto, Keiko Ono, Satoko Umeda, Kosuke Yoshida, Toshiaki Teratani, Takahiro Suzuki, Yohei Mikami, Nobuhiro Nakamoto, Nobuo Sasaki, Kaoru Takabayashi, Naoki Hosoe, Haruhiko Ogata, Kazuaki Sawada, Takeshi Imamura, Akihiko Yoshimura, Takanori Kanai,

Original paper Differences in interaction lead to the formation of different types of insulin amyloid

scientific reports.， 2022； 12：8556

DOI:10.1038/s41598-022-12212-6

Wakako Mori, Ryosuke Kawakami, Yosuke Niko, Tomohiro Haruta, Takeshi Imamura, Kentaro Shiraki & Tamotsu Zako

Original paper Computer-Aided Detection of Quantitative Signatures for Breast Fibroepithelial Tumors Using Label-Free Multi-Photon Imaging

Molecules.， 2022； 27(10)：3340

DOI:10.3390/molecules27103340

Kana Kobayashi-Taguchi, Takashi Saitou, Yoshiaki Kamei, Akari Murakami, Kanako Nishiyama, Reina Aoki, Erina Kusakabe, Haruna Noda, Michiko Yamashita, Riko Kitazawa, Takeshi Imamura and Yasutsugu Takada

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