To the Future with
PROTEO-SCIENCE

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プライムの情報はこちら

INFORMATION

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ABOUT PROS

Proteins are the building blocks of life. The wheat cell-free protein synthesis method, pioneered here at PROS, enables the high-throughput, large scale synthesis of high quality proteins.

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PRiME

PRiME is a joint-use, collaborative research center focusing on interactome analysis set up by the Proteo-Science Center at Ehime University.
Collaborative research is the bedrock of our center, and we are continuously adapting our program to facilitate our ability to work together with researchers all over the world.

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DEPARTMENTS

The Proteo-Science Center at Ehime University consists of various diverse research departments affiliated with 'Fundamental Technology Development‘ and 'Complex Bioscience Analysis’. We aim to promote protein-based life science research, and to use our expertise to inform the development of novel diagnostics and therapeutics for the improvement of human health.

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イメージ：研究部門

ACHIEVEMENTS

Original paper Bub1 suppresses inflammatory arthritis-associated bone loss in mice through inhibition of TNFα-mediated osteoclastogenesis

J Bone Miner Res.， 2024； 39(3)：341-356
DOI:10.1093/jbmr/zjae015
Yoshida S, Ikedo A, Yanagihara Y, Sakaue T, Saeki N, ImaiY

Original paper Membrane-Associated Ubiquitin Ligase RING Finger Protein 152 Orchestrates Melanogenesis via Tyrosinase Ubiquitination

Membranes.， 2024； 14：43
DOI:https://doi.org/10.3390/membranes14020043
Ryota Ueda, Rina Hashimoto, Yuki Fujii, José C J M D S Menezes, Hirotaka Takahashi, Hiroyuki Takeda, Tatsuya Sawasaki, Tomonori Motokawa, Kenzo Tokunaga, Hideaki Fujita

Original paper Design of Ancestral Sortase E that is Applicable in Protein Biomaterial Synthesis

ACS Catalysis.， 2024； 14：3514–3523
DOI:https://doi.org/10.1021/acscatal.4c00487
Azusa Miyata, Taichi Chisuga, Akira Kambe, Ryo Miyata, Yui Kawamura, Hiroyuki Takeda*, Sohei Ito*, and Shogo Nakano*

Original paper Comparative analysis of Hmx expression and the distribution of neuronal somata in the trigeminal ganglion in lamprey and shark insights into the homology of the trigeminal nerve branches and the evolutionary origin of the vertebrate jaw

Zoological Letters.， 2023； 9：23
DOI:10.1186/s40851-023-00222-9
Motoki Tamura, Ryota Ishikawa, Yuki Nakanishi, Juan Pascual‑Anaya, Makiko Fukui, Takashi Saitou, Fumiaki Sugahara, Filippo M. Rijli, Shigeru Kuratani, Daichi G. Suzuki, Yasunori Murakami

Original paper Reinforced anti-myeloma therapy via dual-lymphoid activation mediated by a panel of antibodies armed with Bridging-BiTE

Blood.， 2023； 142 (21)：1789-1805
DOI:10.1182/blood.2022019082
Tatsuya Konishi, Toshiki Ochi, Masaki Maruta, Kazushi Tanimoto, Yukihiro Miyazaki, Chika Iwamoto, Takashi Saitou, Takeshi Imamura, Masaki Yasukawa, Katsuto Takenaka
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