To the Future with
PROTEO-SCIENCE

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プライムの情報はこちら

INFORMATION

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ABOUT PROS

Proteins are the building blocks of life. The wheat cell-free protein synthesis method, pioneered here at PROS, enables the high-throughput, large scale synthesis of high quality proteins.

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PRiME

PRiME is a joint-use, collaborative research center focusing on interactome analysis set up by the Proteo-Science Center at Ehime University.
Collaborative research is the bedrock of our center, and we are continuously adapting our program to facilitate our ability to work together with researchers all over the world.

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DEPARTMENTS

The Proteo-Science Center at Ehime University consists of various diverse research departments affiliated with 'Fundamental Technology Development‘ and 'Complex Bioscience Analysis’. We aim to promote protein-based life science research, and to use our expertise to inform the development of novel diagnostics and therapeutics for the improvement of human health.

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イメージ：研究部門

ACHIEVEMENTS

Original paper PI3K-Akt signalling regulates Scx-lineage tenocytes and Tppp3-lineage paratenon sheath cells in neonatal tendon regeneration

Nat Commun..， 2025； 16：3734
DOI:10.1038/s41467-025-59010-y
Goto A, Komura S, Kato K, Maki R, Hirakawa A, Aoki H, Tomita H, Taguchi J, Ozawa M, Matsushima T, Kishida A, Kimura T, Asahara H, Imai Y, Yamada Y, Akiyama H.

Original paper The splicing factor Acin1 is essential for embryonic development but has limited effects on muscle structure and homeostasis

Scientific Reports..， 2025； 15：14017
DOI:10.1038/s41598-025-98851-x
Aoto M, Sakai H, Tokunaga N, Miyazaki M, Kiyoi T, Ohkubo N, Imai Y, Mitsuda N.

Original paper Density and structure of DNA immobilised on gold nanoparticles affect sensitivity in nucleic acid detection

Sci. Rep..， 2025； 15：8222
DOI:10.1038/s41598-025-92474-y
Nanami Fukuzumi, Gen Hirao, Atsushi Ogawa, Tsuyoshi Asahi, Mizuo Maeda, Tamotsu Zako

Original paper Cell-Free Multistep Gene Regulatory Cascades Using Eukaryotic ON-Riboswitches Responsive to in Situ Expressed Protein Ligands

ACS Synth. Biol..， 2025； 14：909-918
DOI:10.1021/acssynbio.4c00840
Atsushi Ogawa, Masahiro Fujikawa, Riku Tanimoto, Kiho Matsuno, Riko Uehara, Honami Inoue, Hajime Takahashi

Original paper Effect of DNA Density on Nucleic Acid Detection Using Cross-Linking Aggregation of DNA-Modified Gold Nanoparticles

Langmuir.， 2025； 41：4560-4568
DOI:10.1021/acs.langmuir.4c04343
Yuki Tanaka, Gen Hirao, Nanami Fukuzumi, Tsuyoshi Asahi, Mizuo Maeda, Atsushi Ogawa, Tamotsu Zako
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