To the Future with
PROTEO-SCIENCE

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ABOUT PROS

Proteins are the building blocks of life. The wheat cell-free protein synthesis method, pioneered here at PROS, enables the high-throughput, large scale synthesis of high quality proteins.

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PRiME

PRiME is a joint-use, collaborative research center focusing on interactome analysis set up by the Proteo-Science Center at Ehime University.
Collaborative research is the bedrock of our center, and we are continuously adapting our program to facilitate our ability to work together with researchers all over the world.

DEPARTMENTS

The Proteo-Science Center at Ehime University consists of various diverse research departments affiliated with 'Fundamental Technology Development‘ and 'Complex Bioscience Analysis’. We aim to promote protein-based life science research, and to use our expertise to inform the development of novel diagnostics and therapeutics for the improvement of human health.

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ACHIEVEMENTS

Original paper Comparative analysis of Hmx expression and the distribution of neuronal somata in the trigeminal ganglion in lamprey and shark insights into the homology of the trigeminal nerve branches and the evolutionary origin of the vertebrate jaw

Zoological Letters., 2023; 9:23
DOI:10.1186/s40851-023-00222-9
Motoki Tamura, Ryota Ishikawa, Yuki Nakanishi, Juan Pascual‑Anaya, Makiko Fukui, Takashi Saitou, Fumiaki Sugahara, Filippo M. Rijli, Shigeru Kuratani, Daichi G. Suzuki, Yasunori Murakami

Original paper Reinforced anti-myeloma therapy via dual-lymphoid activation mediated by a panel of antibodies armed with Bridging-BiTE

Blood., 2023; 142 (21):1789-1805
DOI:10.1182/blood.2022019082
Tatsuya Konishi, Toshiki Ochi, Masaki Maruta, Kazushi Tanimoto, Yukihiro Miyazaki, Chika Iwamoto, Takashi Saitou, Takeshi Imamura, Masaki Yasukawa, Katsuto Takenaka

Original paper Extended Depth of Focus Two-photon Light-sheet Microscopy for in vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

International Journal of Molecular Sciences., 2023; 24 (12):10186
DOI:10.3390/ijms241210186
Takashi Saitou, Takeshi Imamura

Original paper Administration of prosaposin-derived neurotrophic factor to neural tube defects facilitates regeneration and restores neurological functions

iScience., 2023; 26 (4):106277
DOI:10.1016/j.isci.2023.106277
Sakirul Khan, Akihide Takeuchi, Hiroaki Nabeka, Farzana Khan, Tetsuya Shimokawa, Sota Takanezawa, Takashi Saitou, Takeshi Imamura, Tetsuya Tachibana, Akira Nishizono, Fumihiko Hamada, Seiji Matsuda

Original paper Research letter: A New Fluorescent Three-dimensional and Deep-imaging Technique for Histological Identification of Individual Tumor Cells in Extramammary Paget Disease

Experimental Dermatology., 2023; 32 (5):712-714
DOI:10.1111/exd.14759
Masamoto Murakami, Ryosuke Kawakami, Yosuke Niko, Teruko Tsuda, Takeshi Imamura