To the Future with



Proteins are the building blocks of life. The wheat cell-free protein synthesis method, pioneered here at PROS, enables the high-throughput, large scale synthesis of high quality proteins.



PRiME is a joint-use, collaborative research center focusing on interactome analysis set up by the Proteo-Science Center at Ehime University.
Collaborative research is the bedrock of our center, and we are continuously adapting our program to facilitate our ability to work together with researchers all over the world.


The Proteo-Science Center at Ehime University consists of various diverse research departments affiliated with 'Fundamental Technology Development‘ and 'Complex Bioscience Analysis’. We aim to promote protein-based life science research, and to use our expertise to inform the development of novel diagnostics and therapeutics for the improvement of human health.



Original paper (日本語) Reduced dynamic loads due to hip dislocation induce acetabular cartilage degeneration by IL-6 and MMP3 via the STAT3/periostin/NF-κB axis

Sci Rep.., 2022; 12(1):12207
Nakamura Y, Saitou M, Komura S, Matsumoto K, Ogawa H, Miyagawa T, Saitou T, Imamura T, Imai Y, Takayanagi H, Akiyama H.

Original paper (日本語) Induction of iPSC-derived Prg4-positive cells with characteristics of superficial zone chondrocytes and fibroblast-like synovial cells

BMC Mol Cell Biol.., 2022; 30:1-13
Satake T, Komura S, Aoki H, Hirakawa A, Imai Y, Akiyama H.

Original paper Exploring the key anthropological drivers of and barriers to zoonotic malaria preventative behavior in a community exposed to Plasmodium knowlesi infection in Malaysia: protocol for a qualitative study with a participatory research design

BMJ Open., 2022; in press: 
Naserrudin NA, Hod R, Jeffree MS, Culleton R, Ahmed K and Hassan MR

Original paper Systematic review of Plasmodium knowlesi in Indonesia: a risk of emergence in the context of capital relocation to Borneo?

Parasites & Vectors., 2022; in press: 
bin Sa’id I, Kouakou YI, Omorou R, Bienvenu AL, Ahmed K, Culleton R, Picot S

Original paper Highly efficient protein expression of Plasmodium vivax surface antigen, Pvs25, by silkworm and its biochemical analysis

Protein Expr Purif., 2022;  :106096
Miyata T, Minamihata K, Kurihara K, Kamizuru Y, Gotanda M, Obayashi M, Kitagawa T, Sato K, Kimura M, Oyama K, Ikeda Y, Tamaki Y, Lee JM, Sakao K, Hamanaka D, Kusakabe T, Tachibana M, Ibrahim HR.