画像1｜Media｜Proteo-Science Center, Ehime University

To the Future with
PROTEO-SCIENCE

INFORMATION

2024.01.19

ACADEMIC

Malaria Research

PROS Seminar (February 6th 2024)
2023.10.25

ACADEMIC

Parasitology

PROS Seminar (November 6th 2023)
2023.06.29

RESEARCH

Nature Outlook “Malaria” featured a branded content article on malaria research.

ABOUT PROS

Proteins are the building blocks of life. The wheat cell-free protein synthesis method, pioneered here at PROS, enables the high-throughput, large scale synthesis of high quality proteins.

PRiME is a joint-use, collaborative research center focusing on interactome analysis set up by the Proteo-Science Center at Ehime University.
Collaborative research is the bedrock of our center, and we are continuously adapting our program to facilitate our ability to work together with researchers all over the world.

DEPARTMENTS

The Proteo-Science Center at Ehime University consists of various diverse research departments affiliated with 'Fundamental Technology Development‘ and 'Complex Bioscience Analysis’. We aim to promote protein-based life science research, and to use our expertise to inform the development of novel diagnostics and therapeutics for the improvement of human health.

ACHIEVEMENTS

Original paper Corisin induces proteostasis stress to drive epithelial injury and pulmonary fibrosis.

Nat Commun..， 2026； 17：8486

DOI:10.1038/s41467-026-76162-7

Fujimoto H, Yasuma T, D'Alessandro-Gabazza CN, Toda M, Nishihama K, Takeshita A, Fridman D'Alessandro V, Tomaru A, Saiki H, Okano T, Kogue Y, Anoh T, Alhawsawi MAB, Abdel-Hamid AM, Imai B, Fields CJ, Teofanovic J, Leistikow K, Ono R, Nosaka T, Yamazaki H, Yamakawa D, Bando YK, Sugihara F, Kikuta J, Kataoka K, Kondoh Y, Sakaue T, Takeda H, Yano Y, Hataji O, Cann I, Kobayashi T, Gabazza EC.

Original paper Alkyne Two-Phase Strategy: Rapid Generation of TK-285-Derived PROTACs as BRD4 Degraders.

J Med Chem..， 2026； 69：8388-8416

DOI:10.1021/acs.jmedchem.5c03771

Yamakoshi H, Watanabe R, Segawa R, Ishihara R, Tachibana R, Kudo G, Nagasawa S, Yamanaka S, Ito A, Takeda H, Sawasaki T, Yoshino R, Hirokawa T, Doi T, Hirasawa N, Iwabuchi Y.

Original paper Design of Analytical Methods for Protein Adsorption Characteristics at Material Interfaces.

Langmuir.， 2026； 42：17363-17374

DOI:10.1021/acs.langmuir.6c00943

Tanaka K, Nakano Y, Suganuma M, Matsumoto K, Hasegawa T, Nakahara M, Suto K, Ejima D, Imoarai T, Takeda H.

Original paper A lysine-free REC tag system for proximity-biotinylation applications.

Sci Rep..， 2026； 16：4846

DOI:10.1038/s41598-026-35323-w

Tokunaga S, Nagaoka H, Ozawa T, Yamada K, Takeda H, Fujisaki H, Hamada M, Soga F, Kishi H, Takashima E, Sawasaki T.

Original paper Screening and Engineering of Ancestral Sortase Es That Enable High-Fidelity Enzyme Design with Activity Trade-Off.

Bioconjug Chem..， 2026； 37：341-350

DOI:10.1021/acs.bioconjchem.5c00576

Koshiba R, Chisuga T, Fujinami D, Takeda H, Nakano S.

To the Future withPROTEO-SCIENCE