Achievements

Original paper A novel mechanism of “metal gel-shift” by histidine-rich Ni2+-binding Hpn protein from Helicobacter pylori strain SS1.

PLoS One.， 2017； 12：e0172182

DOI:10.1371/journal.pone.0172182. eCollection 2017

Shelake RM, Ito Y, Masumoto J, Morita EH, Hayashi H

Original paper Mechanism of Proliferation of Cultured Human Corneal Endothelial Cells.

Cornea..， 2017； Suppl 1：S41-S45

DOI:10.1097/ICO.0000000000001337

Joko T, Shiraishi A, Kobayashi T, Ohashi Y, Higashiyama S.

Original paper Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development

eLife.， 2017； 6：e28673

DOI:10.7554/eLife.28673

Fran?a CT, White MT, He WQ, Hostetler JB, Brewster J, Frato G, Malhotra I, Gruszczyk J, Huon C, Lin E, Kiniboro B, Yadava A, Siba P, Galinski M, Healer J, Chitnis CE, Cowman AF, Takashima E, Tsuboi T, Tham WH, Fairhurst RM, Rayner JC, King CL, Mueller I

Original paper Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions

PLoS Negl Trop Dis.， 2017； 11：e0005888

DOI:10.1371/journal. pntd.0005888

Longley RJ, White MT, Takashima E, Morita M, Kanoi BN, Li Wai Suen C, Betuela I, Kuehn A, Sripoorote P, Franca CT, Siba P, Robinson LJ, Lacerda M, Sattabongkot J, Tsuboi T, Mueller I

Original paper Naturally acquired humoral and cellular immune responses to Plasmodium vivax merozoite surface protein 8 in patients with P. vivax infection

Malar J..， 2017； 16：211

DOI:10.1186/s12936-017-1837-5

Cheng Y, Wang B, Changrob S, Han JH, Sattabongkot J, Ha KS, Chootong P, Lu F, Cao J, Nyunt MH, Park WS, Hong SH, Lim CS, Tsuboi T, Han ET

Original paper Identification of a novel merozoite surface antigen of Plasmodium vivax, PvMSA180

Malar J..， 2017； 16：133

DOI:10.1186/s12936-017-1760-9

Muh F, Han JH, Nyunt MH, Lee SK, Jeon HY, Ha KS, Park WS, Hong SH, Ahmed MA, Na S, Takashima E, Tsuboi T, Han ET

Original paper Artificial OFF-Riboswitches That Downregulate Internal Ribosome Entry without Hybridization Switches in a Eukaryotic Cell-Free Translation System

ACS Synth. Biol..， 2017； 6：1656-1662

DOI:10.1021/acssynbio.7b00124

Ogawa A, Masuoka H, Ota T

Original paper Perivascular Adipose Tissue Angiotensin II Type 1 Receptor Promotes Vascular Inflammation and Aneurysm Formation.

Hypertension..， 2017； 117：9512

DOI:10.1161/HYPERTENSIONAHA.117.09512

Sakaue T, Suzuki J, Hamaguchi M, Suehiro C, Tanino A, Nagao T, Uetani T, Aono J, Nakaoka H, Kurata M, Sakaue T, Okura T, Yasugi T, Izutani H, Higaki J, Ikeda S.

Original paper The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells.

Si. Rep..， 2017； 7：42845

DOI:10.1016/j.surg.2016.12.017

Sakaue T, Sakakibara I, Uesugi T, Fujisaki A, Nakashiro KI, Hamakawa H, Kubota E, Joh T, Imai YK, Izutani H, Higashiyama S.

Original paper Downregulation of ANP32B exerts anti-apoptotic effects in hepatocellular carcinoma.

PLoS One..， 2017； 12：e0177343

DOI:10.1371/journal.pone.0177343

Ohno Y, Koizumi M, Nakayama H, Watanabe T, Hirooka M, Tokumoto Y, Kuroda T, Abe M, Fukuda S, Higashiyama S, Kumagi T, Hiasa Y.

Original paper Glutamate-dependent ectodomain shedding of neuregulin-1 type II precursors in rat forebrain neurons.

PLoS One..， 2017； 12：e0174780

DOI:10.1371/journal.pone.0174780

Iwakura Y, Wang R, Inamura N, Araki K, Higashiyama S, Takei N, Nawa H.

Original paper Bone Formation Is Coupled to Resorption Via Suppression of Sclerostin Expression by Osteoclasts

J Bone Miner Res.， 2017； 32：2074–2086

DOI:10.1002/jbmr.3175

Koide M, Kobayashi Y, Yamashita T, Uehara S, Nakamura M, Hiraoka BY, Ozaki Y, Iimura T, Yasuda H, Takahashi N, Udagawa N

Original paper Acute development of cortical porosity and endosteal naïve bone formation from the daily but not weekly short-term administration of PTH in rabbit

PLoS One.， 2017； 12(4)：e0175329

DOI:10.1371/journal.pone.0175329

Yamane H, Takakura A, Shimadzu Y, Kodama T, Lee JW, Isogai Y, Ishizuya T, Takao-Kawabata R, Iimura T

Original paper Angubindin-1, a novel paracellular absorption enhancer acting at the tricellular tight junction

Journal of Controlled Release.， 2017； 260：44572

DOI:10.1016/j.jconrel.2017.05.024

Susanne M. Krug, Tomohiro Hayaishi, Daisuke Iguchi, Akihiro Watari, Azusa Takahashi, Michael Fromm, Masahiro Nagahama, Hiroyuki Takeda, Yoshiaki Okada, Tatsuya Sawasaki, Takefumi Doi, Kiyohito Yagi, Masuo Kondoh

Original paper CP5 system, for simple and highly efficient protein purification with a C-terminal designed mini tag

PLOS ONE.， 2017；：

DOI:10.1371/journal.pone.0178246

Hiroyuki Takeda, Wei Zhou, Kohki Kido, Ryoji Suno, Takahiro Iwasaki, Takuya Kobayashi, Tatsuya Sawasaki

Original paper Crystal structure and redox properties of a novel cyanobacterial heme-protein with a His/Cys heme axial ligation and a per-arnt-sim (PAS)-like domain

Ｊ. Biol. Chem..， 2017； 292：9599-9612

DOI:10.1074/jbc.M116.746263

Motomura, T., Suga, M., Hienerwadel, R., Nakagawa, A., Lai, T.-L., Nitschke, W., Sugiura, M, Boussac, A. and Shen, J.-R.

Original paper Early diagnosis of early-onset sarcoidosis: a case report with functional analysis and review of the literature

Clin Rheumatol.， 2017； in press：in press

DOI:10.1007/s10067-017-3544-6

Takeuchi Y, Shigemura T, Kobayashi N, Kaneko N, Iwasaki T, Minami K, Kobayashi K, Masumoto J, Agematsu K

Original paper Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks.

FEBS Lett..， 2017；：

DOI:10.1002/1873-3468.12596

Yamamoto T, Taira Nihira N, Yogosawa S, Aoki K, Takeda H, Sawasaki T, Yoshida K.

Original paper Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop.

Nat Commun..， 2016； 7：12596

DOI:10.1038/ncomms12596

Kuwahara M, Ise W, Ochi M, Suzuki J, Kometani K, Maruyama S, Izumoto M, Matsumoto A, Takemori N, Takemori A, Shinoda K, Nakayama T, Ohara O, Yasukawa M, Sawasaki T, Kurosaki T, Yamashita M.

Original paper HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains.

PLoS Pathog..， 2017； 13：e1006162

DOI:10.1371/journal.ppat.1006162

Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, Inoue JI.

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