Achievements

Original paper The Cullin3-Rbx1-KCTD10 complex controls endothelial barrier function via K63-ubiquitination of RhoB.

J. Cell Biol..， 2018； 217：1015-1032

DOI:10.1083/jcb.201606055

Kovacevic I, Sakaue T, Majolee J, Pronk MC, Maekawa M, Geerts D, Fernandez-Borja M, Higashiyama S and Hordijk PL.

Original paper Identification of target proteins of clinical immunity to Plasmodium falciparum in a region of low malaria transmission

Parasitol Int..， 2018； 67：203-208

DOI:10.1016/j.parint.2017.12.002

Sakamoto H, Takeo S, Takashima E, Miura K, Kanoi BN, Kaneko T, Han ET, Tachibana M, Matsuoka K, Sattabongkot J, Udomsangpetch R, Ishino T, Tsuboi T

Original paper Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors

Nature.， 2017； 552：101-105

DOI:10.1038/nature24994

Saito F, Hirayasu K, Satoh T, Wang CW, Lusingu J, Arimori T, Shida K, Palacpac NMQ, Itagaki S, Iwanaga S, Takashima E, Tsuboi T, Kohyama M, Suenaga T, Colonna M, Takagi J, Lavstsen T, Horii T, Arase H

Original paper The HIV co-receptor CCR5 regulates osteoclast function

Nat Commun..， 2017； 8：2226

DOI:10.1038/s41467-017-02368-5

Lee JW, Hoshino A, Inoue K, Saitou T, Uehara S, Kobayashi Y, Ueha S, Matsushima K, Yamaguchi A, Imai Y, Iimura T.

Original paper Altered gene expression of RNF34 and PACAP possibly involved in mechanism of exercise-induced analgesia for neuropathic pain in rats

International Journal of Molecular Sciences.， 2017； 18(9)：1962

DOI:10.3390/ijms18091962

Shintaro Yamaoka, Yusuke Oshima, Hideki Horiuchi, Tadao Morino, Masayuki Hino, Hiromasa Miura, Tadanori Ogata

Original paper Bisphenol A Inhibits Cell Proliferation and Reduces the Motile Potential of Murine LM8 Osteosarcoma Cells

Anticancer Research.， 2017； 37(4)：1711-1722

DOI:10.21873/anticancers.11503

Teruki Kidani, Rie Yasuda, Joji Miyawaki, Yusuke Oshima, Hiromasa Miura and Hiroshi Masuno

Original paper Both Autocrine Signaling and Paracrine Signaling of HB-EGF Enhance Ocular Neovascularization.

Arterioscler Thromb Vasc Biol..， 2018； 38：174-185

DOI:10.1161/ATVBAHA.117.310337

Inoue Y, Shimazawa M, Nakamura S, Takata S, Hashimoto Y, Izawa H, Masuda T, Tsuruma K, Sakaue T, Nakayama H, Higashiyama S, Hara H.

Original paper Uhrf1 is indispensable for normal limb growth by regulating chondrocyte differentiation through specific gene expression.

Development..， 2018； 145(1)：dev157412

DOI:10.1242/dev.157412

Yamashita M, Inoue K, Saeki N, Ideta-Otsuka M, Yanagihara Y, Sawada Y, Sakakibara I, Lee JW, Ichikawa K, Kamei Y, Iimura T, Igarashi K, Takada Y and Imai Y.

Original paper A novel mechanism of “metal gel-shift” by histidine-rich Ni2+-binding Hpn protein from Helicobacter pylori strain SS1.

PLoS One.， 2017； 12：e0172182

DOI:10.1371/journal.pone.0172182

Shelake RM, Ito Y, Masumoto J, Morita EH, Hayashi H.

Original paper Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head

Sci Rep..， 2017； 7：15035

DOI:10.1038/s41598-017-14778-y

Sakamoto Y, Yamamoto T, Sugano N, Takahashi D, Watanabe T, Atsumi T, Nakamura J, Hasegawa Y, Akashi K, Narita I, Miyamoto T, Takeuchi T, Ikari K, Amano K, Fujie A, Kubo T, Tada Y, Kaneuji A, Nakamura H, Miyamura T, Kabata T, Yamaji K, Okawa T, Sudo A, Ohzono K, Tanaka Y, Yasunaga Y, Matsuda S, Imai Y, Akiyama M, Kudo M, Kamatani Y, Iwamoto Y, Ikegawa S.

Original paper Cullin-3 and its adaptor protein ANKFY1 determine the surface level of integrin β1 in endothelial cells.

Biol. Open..， 2017； 6：1707-1719

DOI:10.1242/bio.029579

Maekawa M, Tanigawa K, Sakaue T, Hiyoshi H, Kubota E, Joh T, Watanabe Y, Taguchi T and Higashiyama S.

Original paper Membrane curvature induced by proximity of anionic phospholipids is sufficient to initiate endocytosis.

Nat. Commun..， 2017； 8：1393

DOI:10.1038/s41467-017-01554-9

Hirama T, Lu SM, Kay JG, Maekawa M, Kozlov M, Grinstein S and Fairn GD.

Original paper The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1.

J Biol Chem..， 2017； 292：12528-12541

DOI:10.1074/jbc.M117.785675

Yonezawa T, Takahashi H, Shikata S, Liu X, Tamura M, Asada S, Fukushima T, Fukuyama T, Tanaka Y, Sawasaki T, Kitamura T, Goyama S.

Original paper Involvement of PUF60 in Transcriptional and Post-transcriptional Regulation of Hepatitis B Virus Pregenomic RNA Expression.

Sci Rep..， 2017； 7：12874

DOI:10.1038/s41598-017-12497-y

Sun S, Nakashima K, Ito M, Li Y, Chida T, Takahashi H, Watashi K, Sawasaki T, Wakita T, Suzuki T.

Original paper Tyrosine phosphorylation of the GARU E3 ubiquitin ligase promotes gibberellin signalling by preventing GID1 degradation.

Nat Commun..， 2017； 8：1004

DOI:10.1038/s41467-017-01005-5

Nemoto K, Ramadan A, Arimura GI, Imai K, Tomii K, Shinozaki K, Sawasaki T.

Original paper Neoatherosclerosis development following bioresorbable vascular scaffoldimplantation in diabetic and non-diabetic swine.

PLoS One..， 2017； 12：e0183419

DOI:10.1371/journal.pone.0183419

van Ditzhuijzen NS1, Kurata M1, van den Heuvel M1, Sorop O1, van Duin RWB1, Krabbendam-Peters I1, Ligthart J1, Witberg K1, Murawska M2, Bouma B3, Villiger M3, Garcia-Garcia HM4, Serruys PW4, Zijlstra F1, van Soest G1, Duncker DJ1, Regar E1,5, van Beusekom HMM1.

Original paper Claudin-5-Binders Enhance Permeation of Solutes across the Blood-Brain Barrier in a Mammalian Model.

J Pharmacol Exp Ther.， 2017； 363：275-283

DOI:10.1124/jpet.117.243014

Yosuke Hashimoto, Keisuke Shirakura, Yoshiaki Okada, Hiroyuki Takeda, Kohki Endo, Maki Tamura, Akihiro Watari, Yoshifusa Sadamura, Tatsuya Sawasaki, Takefumi Doi, Kiyohito Yagi, and Masuo Kondoh

Original paper Efficiency and Safety of CRAC Inhibitors in Human Rheumatoid Arthritis Xenograft Models

J. Immunol..， 2017； 199：1584-1595

DOI:10.4049/jimmunol.1700192

Shuang Liu, Hitoshi Hasegawa, Erika Takemasa, Yasuyuki Suzuki, Keizou Oka, Takeshi Kiyoi, Hiroyuki Takeda, Tomio Ogasawara, Tatsuya Sawasaki, Masaki Yasukawa and Kazutaka Maeyama

Original paper Comparison of serum inflammatory cytokine concentrations in familial Mediterranean fever and rheumatoid arthritis patients.

Scandinavian Journal of Rheumatology.， 2017； in press：in press

DOI:10.1080/03009742.2017.1363281

Koga T, Kawashiri SY, Migita K, Sato S, Umeda M, Fukui S, Nishino A, Nonaka F, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Ueki Y, Masumoto J, Agematsu K, Yachie A, Eguchi K, Kawakami A

Original paper Poly (I:C) and hyaluronic acid directly interact with NLRP3, resulting in the assembly of NLRP3 and ASC in a cell-free system.

European Journal of Inflammation.， 2017； 15：85-97

DOI:10.1177/1721727X17711047

Kaneko N, Ito Y, Iwasaki T, Takeda H, Sawasaki T, Migita K, Agematsu K, Koga T, Kawakami A, Yachie A, Yoshiura K ,Morikawa S, Kurata M, Masumoto J

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