Achievements

Original paper Biochemical and histological evidence of deteriorated bioprosthetic valve leaflets: the accumulation of fibrinogen and plasminogen.

Biol Open..， 2018； 7：bio034009

DOI:10.1242/bio.034009

Sakaue T, Nakaoka H, Shikata F, Aono J, Kurata M, Uetani T, Hamaguchi M, Kojima A, Uchita S, Yasugi T, Higashi H, Suzuki J, Ikeda S, Higaki J, Higashiyama S, Izutani H.

Original paper IAPP/amylin deposition, which is correlated with expressions of ASC and IL-1β in β-cells of Langerhans’ islets, directly initiates NLRP3 inflammasome activation.

Int J Immunopathol Pharmacol..， 2018； 32：2.06E+15

DOI:10.1177/2058738418788749

Morikawa S, Kaneko N, Okumura C, Taguchi H, Kurata M, Yamamoto T, Osawa H, Nakanishi A, Zako T, Masumoto J.

Original paper Combined morphological, immunohistochemical and genetic analyses of medulloepithelioma in the posterior cranial fossa.

Neuropathology..， 2018； 38：179-184

DOI:10.1111/neup.12431

Kusakabe K, Kohno S, Inoue A, Seno T, Yonezawa S, Moritani K, Mizuno Y, Kurata M, Kitazawa R, Tauchi H, Watanabe H, Iwata S, Hirato J, Kunieda T.

Original paper MicroRNA-204-3p inhibits lipopolysaccharide-induced cytokines in familial Mediterranean fever via the phosphoinositide 3-kinase γ pathway.

Rheumatology (Oxford).， 2018； 57：718-726

DOI:10.1093/rheumatology/kex451

Koga T, Migita K, Sato T, Sato S, Umeda M, Nonaka F, Fukui S, Kawashiri SY, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Ueki Y, Masumoto J, Agematsu K, Yachie A, Yoshiura KI, Eguchi K, Kawakami A.

Original paper Musculoskeletal manifestations occur predominantly in patients with later-onset familial Mediterranean fever: Data from a multicenter, prospective national cohort study in Japan.

Arthritis Res Ther..， 2018； 20：Article number 257

DOI:10.1186/s13075-018-1738-1

Endo Y, Koga T, Ishida M, Fujita Y, Tsuji S, Takatani A, Shimizu T, Sumiyoshi R, Igawa T, Umeda M, Fukui S, Nishino A, Kawashiri S, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Agematsu K, Yachie A, Masumoto J, Migita K, Kawakami A.

Original paper Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: Identification of an intrinsic NLRP3 ligand in a cell-free system

Inflamm Regen.， 2018；：

DOI:10.1186/s41232-018-0085-6

Nakanishi A, Kaneko N, Takeda H, Sawasaki T, Morikawa S, Zhou W, Kurata M, Yamamoto T, Akbar SMF, Zako T, Masumoto J.

Original paper Treatment of chronic hepatitis B naïve patuents with a therapeutic vaccine containing HBs and HBc antigens (a randomized, open and treatment controlled phase III clinical trial)

Plos One..， 2018； 13：20201236

DOI:10.1371/journal.pone.0201236

Al Mahtab M, Akbar SMF, Aguilar JC, Guillen G, Penton E, Tuero A, Yoshida O, Hiasa Y, Onji M.

Original paper Cerebral amyloid angiopathy-related inflammation with epilepsy mimicking a presentation of brain tumor: A case report and review of the literature.

Int J Surg Case Rep..， 2018； 48：95-100

DOI:10.1016/j.ijscr.2018.05.016

Kusakabe K, Inoue A, Matsumoto S, Kurata M, Kitazawa R, Watanabe H, Kunieda T.

Original paper Comprehensive analysis of antibody responses to Plasmodium falciparum erythrocyte membrane protein 1 domains

Vaccine.， 2018； 36：6826–6833

DOI:10.1016/j.vaccine.2018.08.058

Kanoi BN, Nagaoka H, Morita M, White MT, Palacpac NMQ, Ntege EH, Balikagala B, Yeka A, Egwang TG, Horii T, Tsuboi T, Takashima E

Original paper Mechanism of proton-coupled electron transfer in the S0-to-S1 transition of photosynthetic water oxidation as revealed by time-resolved infrared spectroscopy

J. Phys. Chem. B.， 2018； 122：9460-9470

DOI:10.1021/acs.jpcb.8b07455

Shimizu, T. Sugiura, M., and Noguchi, T.

Original paper Functional G-Protein-Coupled Receptor (GPCR) Synthesis: The Pharmacological Analysis of Human Histamine H1 Receptor (HRH1) Synthesized by a Wheat Germ Cell-Free Protein Synthesis System Combined with Asolectin Glycerosomes.

Front Pharmacol..， 2018； 9：38

DOI:10.3389/fphar.2018.00038

Suzuki Y, Ogasawara T, Tanaka Y, Takeda H, Sawasaki T, Mogi M, Liu S, Maeyama K.

Original paper Engineered membrane protein antigens successfully induce antibodies against extracellular regions of claudin-5.

Scientific Reports.， 2018； 8：8383

DOI:10.1038/s41598-018-26560-9

Yosuke Hashimoto, Wei Zhou, Kohtaroh Hamauchi, Keisuke Shirakura, Takefumi Doi, Kiyohito Yagi, Tatsuya Sawasaki, Yoshiaki Okada, Masuo Kondoh, Hiroyuki Takeda

Original paper Progress toward a transmission-blocking vaccine against malaria

Lancet Infect Dis..， 2018； 18：927-928

DOI:10.1016/S1473-3099(18)30358-X

Ishino T, Tsuboi T

Original paper Plasmodium falciparum Exported Protein 1 is localized to dense granules in merozoites

Parasitol Int..， 2018； 67：637-639

DOI:10.1016/j.parint.2018.06.001

Iriko H, Ishino T, Otsuki H, Ito D, Tachibana M, Torii M, Tsuboi T

Original paper Characterization of Plasmodium berghei Pbg37 as Both a Pre- and Postfertilization Antigen with Transmission-Blocking Potential

Infect Immun..， 2018； 86：e00785-17

DOI:10.1128/IAI.00785-17

Liu F, Li L, Zheng W, He Y, Wang Y, Zhu X, Tsuboi T, Cui L, Wang M, Cao Y

Original paper The malaria parasite RhopH protein complex interacts with erythrocyte calmyrin identified from a comprehensive erythrocyte protein library

Biochem Biophys Res Commun..， 2018； 500：261-267

DOI:10.1016/j.bbrc.2018.04.056

Miura T, Takeo S, Ntege EH, Otsuki H, Sawasaki T, Ishino T, Takashima E, Tsuboi T

Original paper Molecular Camouflage of Plasmodium falciparum Merozoites by Binding of Host Vitronectin to P47 Fragment of SERA5

Sci Rep..， 2018； 8：5052

DOI:10.1038/s41598-018-23194-9

Tougan T, Edula JR, Takashima E, Morita M, Shinohara M, Shinohara A, Tsuboi T, Horii T

Original paper Artemisinin-Resistant Plasmodium falciparum with High Survival Rates, Uganda, 2014-2016

Emerg Infect Dis..， 2018； 24：718-726

DOI:10.3201/eid2404.170141

Ikeda M, Kaneko M, Tachibana SI, Balikagala B, Sakurai-Yatsushiro M, Yatsushiro S, Takahashi N, Yamauchi M, Sekihara M, Hashimoto M, Katuro OT, Olia A, Obwoya PS, Auma MA, Anywar DA, Odongo-Aginya EI, Okello-Onen J, Hirai M, Ohashi J, Palacpac NMQ, Kataoka M, Tsuboi T, Kimura E, Horii T, Mita T

Original paper PV1, a novel Plasmodium falciparum merozoite dense granule protein, interacts with exported protein in infected erythrocytes

Sci Rep..， 2018； 8：3696

DOI:10.1038/s41598-018-22026-0

Morita M, Nagaoka H, Ntege EH, Kanoi BN, Ito D, Nakata T, Lee JW, Tokunaga K, Iimura T, Torii M, Tsuboi T, Takashima E

Original paper The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation

Nat Commun..， 2018； 9：3296

DOI:10.1038/s41467-018-05854-6

Suzuki J, Yamada T, Inoue K, Nabe S, Kuwahara M, Takemori N, Takemori A, Matsuda S, Kanoh M, Imai Y, Yasukawa M, Yamashita M.

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