Achievements

Original paper Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T cells Improves Their Use in Cancer Immunotherapy.

Cell Stem Cell..， 2018； 23 (6)：850-858

DOI:10.1016/j.stem.2018.10.005

Minagawa A, YOshikawa T, Yasukawa M, Hotta A, Kunimoto M, Iriguchi S, Takiguchi M, Kassai Y, Imai E, Yasui Y, Kawai Y, Zhang R, Uemura Y, Miyoshi H, Nakanishi M, Watanabe A, Hayashi A, Kawana K, Fujii T, Nakatsura T, Kaneko S.

Original paper Cullin-3/KCTD10 E3 complex is essential for Rac1 activation through RhoB degradation in human epidermal growth factor 2-positive breast cancer cells.

Cancer Sci..， 2019； 110：650-661

DOI:10.1111/cas.13899

Murakami A, Maekawa M, Kawai K, Nakayama J, Araki N, Semba K, Taguchi T, Kamei Y, Takada Y and Higashiyama S.

Original paper Mechanisms underlying the lack of endogenous processing and CLIP-mediated binding of the invariant chain by HLA-DP84GLY.

Sci Rep..， 2018； 8：4804

DOI:10.1038/s41598-018-22931-4

Anczurowski M, Yamashita Y, Nakatsugawa M, Ochi T, Kagoya Y, Guo T, Wang CH, Rahman MA, Saso K, Butler MO, Hirano N.

Original paper Raman Spectroscopic Analysis to Detect Reduced Bone Quality after Sciatic Neurectomy in Mice

Molecules..， 2018； 23：12

DOI:10.3390/molecules23123081

Ishimaru Y, Oshima Y, Imai Y, Iimura T, Takanezawa S, Hino K, Miura H.

Original paper The micronemal Plasmodium proteins P36 and P52 act in concert to establish the replication-permissive compartment within infected hepatocytes.

Fron Cell Infect Microbiol.， 2018； 8：413

DOI:10.3389/fcimb.2018.00413

Silvia A. Arredondo, Kristian E. Swearingen, Thomas Martinson, Ryan Steel, Dorender A. Dankwa, Anke Harupa, Nelly Camargo, William Betz, Vladimir Vigdorovich, Brian G. Oliver, Niwat Kangwanrangsan, Tomoko Ishino, Noah Sather, Sebastian Mikolajczak, Ashley M. Vaughan, Motomi Torii, Robert L. Moritz, Stefan H.I. Kappe

Original paper The Plasmodium yoelii microgamete surface antigen (PyMiGS) induces anti-malarial transmission blocking immunity that reduces microgamete motility/release from activated male gametocytes.

Vaccine.， 2018； 36(49)：7463-7471

DOI:10.1016/j.vaccine.2018.10.067

Mayumi Tachibana, Tomoko Ishino, Takafumi Tsuboi, Motomi Torii

Original paper The critical role of Bach2 in regulating type-2 chronic airway inflammation.

Int Immunol..， 2018； 30：397-402

DOI:10.1093/intimm/dxy020

Yamashita M, Kuwahara M.

Original paper The tumor suppressor menin prevents effector CD8T-cell dysfunction by targeting mTORC1-dependent metabolic activation.

Nat Commun..， 2018； 9：3296

DOI:10.1038/s41467-018-05854-6

Suzuki J, Yamada T, Inoue K, Nabe S, Kuwahara M, Takemori N, Takemori A, Matsuda S, Kanoh M, Imai Y, Yasukawa M, Yamashita M.

Original paper An unusual, CD4 and CD8 dual-positive, CD25 negative,tumor cell phenotype in a patient with adult T-cell leukemia/lymphoma.

Leuk Lymphoma..， 2018； 21：44564

DOI:10.1080/10428194.2018.1439168

Casey N, Fujiwara H, Azuma T, Murakami Y, Yoshimitsu M, Masamoto I, Nawa Y, Yamannouchi J, Narumi H, Yakushijin Y, Hato T, Yasukawa M.

Original paper Development of an FVIII Inhibitor in a Mild Hemophilia Patient with a Phe595Cys Mutation.

Intern Med..， 2018； 57：3179-3182

DOI:10.2169/internalmedicine.1145-18

Yamanouchi J, Tokumoto D, Ikeda Y, Maruta M, Kaneko M, Hato T, Yasukawa M.

Original paper Association of platelet response to cilostazol with clinical outcome and CYP genotype in patients with cerebral infarction.

Thromb Res..， 2018； 172：14-20

DOI:10.1016/j.thromres.2018.10.003

Ikeda Y, Yamanouchi J, Kumon Y, Yasukawa M, Hato T.

Original paper Reinforce the antitumor activity of CD8+ T cells via glutamine restriction.

Cancer Sci..， 2018； 9：44575

DOI:10.1111/cas.13827

Nabe S, Yamada T, Suzuki J, Yasuoka T, Kuwahara M, Shiraishi A, Takenaka K, Yasukawa M, Yamashita M.

Original paper Rhoptry neck protein 2 expressed in Plasmodium sporozoites plays a crucial role during invasion of mosquito salivary glands.

Cell Microbiol.， 2019； 21：e12964

DOI:10.1111/cmi.12964

Tomoko Ishino, Eri Murata, Naohito Tokunaga, Minami Baba, Mayumi Tachibana, Amporn Thongkukiatkul, Takafumi Tsuboi, Motomi Torii

Original paper Anti-MSP11 IgG inhibits Plasmodium falciparum merozoite invasion into erythrocytes in vitro.

Parasitol. Int..， 2019； 69：25-29

DOI:10.1016/j.parint.2018.10.012

Tatsuhiro Tohmoto, Eizo Takashima, Satoru Takeo, Masayuki Morita, Hikaru Nagaoka, Rachanee Udomsangpetch, Jetsumon Sattabongkot, Tomoko Ishino, Motomi Torii, Takafumi Tsuboi

Original paper Antibodies against a Plasmodium falciparum RON12 inhibit merozoite invasion into erythrocytes.

Parasitol. Int..， 2019； 68(1)：87-91

DOI:10.1016/j.parint.2018.10.006

Daisuke Ito, Eizo Takashima, Tsutomu Yamasaki, Shinya Hatano, Tomoyuki Hasegawa, Kazutoyo Miura, Masayuki Morita, Amporn Thongkukiatkul, Mahamadou Diakite, Carole A.Long, Jetsumon Sattabongkot, Rachanee Udomsangpetch, Hideyuki Iriko, Tomoko Ishino, Takafumi Tsuboi.

Original paper Plasmodium RON12 localizes to the rhoptry body in sporozoites.

Parasitol Int.， 2019； 68(1)：17-23

DOI:10.1016/j.parint.2018.10.001

YukiOda-Yokouchi, Mayumi Tachibana, Hideyuki Iriko, Motomi Torii, Tomoko Ishino, Takafumi Tsuboi.

Original paper Cytotoxic anti-circumsporozoite antibodies target malaria sporozoites in the host skin.

Nature Microbiol..， 2018； 3：1224–1233

DOI:10.1038/s41564-018-0254-z

Eduardo Aliprandini, Joana Tavares, Raquel Hoffmann Panatieri, Sabine Thiberge, Marcio Massao Yamamoto, Olivier Silvie, Tomoko Ishino, Masao Yuda, Sylvie Dartevelle, Fran?ois Traincard, Silvia Beatriz Boscardin, Rogerio Amino.

Original paper Activation of Pyk2 by CaM kinase II in cultured hypothalamic neurons and gonadotroph cells.

J Cell Physiol..， 2019； 234：6865-6875

DOI:10.1002/jcp.27443

Okitsu-Sakurayama S, Higa-Nakamine S, Torihara H, Takahashi H, Higashiyama S, Yamamoto H.

Original paper Probing the role of Valine 185 of the D1 protein in the Photosystem II oxygen evolution

Biochim. Biophys. Acta (Bioenergetics).， 2018； 1859：1259-1273

DOI:10.1016/j.bbabio.2018.10.003

Sugiura, M., Tibiletti, T., Takachi, I., Hara, Y., Kanawaku, S., Sell?s, J., and Boussac, A.

Original paper Quantitative Morphometry for Osteochondral Tissues Using Second Harmonic Generation Microscopy and Image Texture Information.

Sci Rep..， 2018； 8：2826

DOI:10.1038/s41598-018-21005-9

Saitou T, Kiyomatsu H, Imamura T.

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