Achievements

Original paper Plasmodium RON12 localizes to the rhoptry body in sporozoites.

Parasitol Int.， 2019； 68(1)：17-23

DOI:10.1016/j.parint.2018.10.001

YukiOda-Yokouchi, Mayumi Tachibana, Hideyuki Iriko, Motomi Torii, Tomoko Ishino, Takafumi Tsuboi.

Original paper Cytotoxic anti-circumsporozoite antibodies target malaria sporozoites in the host skin.

Nature Microbiol..， 2018； 3：1224–1233

DOI:10.1038/s41564-018-0254-z

Eduardo Aliprandini, Joana Tavares, Raquel Hoffmann Panatieri, Sabine Thiberge, Marcio Massao Yamamoto, Olivier Silvie, Tomoko Ishino, Masao Yuda, Sylvie Dartevelle, Fran?ois Traincard, Silvia Beatriz Boscardin, Rogerio Amino.

Original paper Activation of Pyk2 by CaM kinase II in cultured hypothalamic neurons and gonadotroph cells.

J Cell Physiol..， 2019； 234：6865-6875

DOI:10.1002/jcp.27443

Okitsu-Sakurayama S, Higa-Nakamine S, Torihara H, Takahashi H, Higashiyama S, Yamamoto H.

Original paper Probing the role of Valine 185 of the D1 protein in the Photosystem II oxygen evolution

Biochim. Biophys. Acta (Bioenergetics).， 2018； 1859：1259-1273

DOI:10.1016/j.bbabio.2018.10.003

Sugiura, M., Tibiletti, T., Takachi, I., Hara, Y., Kanawaku, S., Sell?s, J., and Boussac, A.

Original paper Quantitative Morphometry for Osteochondral Tissues Using Second Harmonic Generation Microscopy and Image Texture Information.

Sci Rep..， 2018； 8：2826

DOI:10.1038/s41598-018-21005-9

Saitou T, Kiyomatsu H, Imamura T.

Original paper Biochemical and histological evidence of deteriorated bioprosthetic valve leaflets: the accumulation of fibrinogen and plasminogen.

Biol Open..， 2018； 7：bio034009

DOI:10.1242/bio.034009

Sakaue T, Nakaoka H, Shikata F, Aono J, Kurata M, Uetani T, Hamaguchi M, Kojima A, Uchita S, Yasugi T, Higashi H, Suzuki J, Ikeda S, Higaki J, Higashiyama S, Izutani H.

Original paper IAPP/amylin deposition, which is correlated with expressions of ASC and IL-1β in β-cells of Langerhans’ islets, directly initiates NLRP3 inflammasome activation.

Int J Immunopathol Pharmacol..， 2018； 32：2.06E+15

DOI:10.1177/2058738418788749

Morikawa S, Kaneko N, Okumura C, Taguchi H, Kurata M, Yamamoto T, Osawa H, Nakanishi A, Zako T, Masumoto J.

Original paper Combined morphological, immunohistochemical and genetic analyses of medulloepithelioma in the posterior cranial fossa.

Neuropathology..， 2018； 38：179-184

DOI:10.1111/neup.12431

Kusakabe K, Kohno S, Inoue A, Seno T, Yonezawa S, Moritani K, Mizuno Y, Kurata M, Kitazawa R, Tauchi H, Watanabe H, Iwata S, Hirato J, Kunieda T.

Original paper MicroRNA-204-3p inhibits lipopolysaccharide-induced cytokines in familial Mediterranean fever via the phosphoinositide 3-kinase γ pathway.

Rheumatology (Oxford).， 2018； 57：718-726

DOI:10.1093/rheumatology/kex451

Koga T, Migita K, Sato T, Sato S, Umeda M, Nonaka F, Fukui S, Kawashiri SY, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Ueki Y, Masumoto J, Agematsu K, Yachie A, Yoshiura KI, Eguchi K, Kawakami A.

Original paper Musculoskeletal manifestations occur predominantly in patients with later-onset familial Mediterranean fever: Data from a multicenter, prospective national cohort study in Japan.

Arthritis Res Ther..， 2018； 20：Article number 257

DOI:10.1186/s13075-018-1738-1

Endo Y, Koga T, Ishida M, Fujita Y, Tsuji S, Takatani A, Shimizu T, Sumiyoshi R, Igawa T, Umeda M, Fukui S, Nishino A, Kawashiri S, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Agematsu K, Yachie A, Masumoto J, Migita K, Kawakami A.

Original paper Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: Identification of an intrinsic NLRP3 ligand in a cell-free system

Inflamm Regen.， 2018；：

DOI:10.1186/s41232-018-0085-6

Nakanishi A, Kaneko N, Takeda H, Sawasaki T, Morikawa S, Zhou W, Kurata M, Yamamoto T, Akbar SMF, Zako T, Masumoto J.

Original paper Treatment of chronic hepatitis B naïve patuents with a therapeutic vaccine containing HBs and HBc antigens (a randomized, open and treatment controlled phase III clinical trial)

Plos One..， 2018； 13：20201236

DOI:10.1371/journal.pone.0201236

Al Mahtab M, Akbar SMF, Aguilar JC, Guillen G, Penton E, Tuero A, Yoshida O, Hiasa Y, Onji M.

Original paper Cerebral amyloid angiopathy-related inflammation with epilepsy mimicking a presentation of brain tumor: A case report and review of the literature.

Int J Surg Case Rep..， 2018； 48：95-100

DOI:10.1016/j.ijscr.2018.05.016

Kusakabe K, Inoue A, Matsumoto S, Kurata M, Kitazawa R, Watanabe H, Kunieda T.

Original paper Comprehensive analysis of antibody responses to Plasmodium falciparum erythrocyte membrane protein 1 domains

Vaccine.， 2018； 36：6826–6833

DOI:10.1016/j.vaccine.2018.08.058

Kanoi BN, Nagaoka H, Morita M, White MT, Palacpac NMQ, Ntege EH, Balikagala B, Yeka A, Egwang TG, Horii T, Tsuboi T, Takashima E

Original paper Mechanism of proton-coupled electron transfer in the S0-to-S1 transition of photosynthetic water oxidation as revealed by time-resolved infrared spectroscopy

J. Phys. Chem. B.， 2018； 122：9460-9470

DOI:10.1021/acs.jpcb.8b07455

Shimizu, T. Sugiura, M., and Noguchi, T.

Original paper Functional G-Protein-Coupled Receptor (GPCR) Synthesis: The Pharmacological Analysis of Human Histamine H1 Receptor (HRH1) Synthesized by a Wheat Germ Cell-Free Protein Synthesis System Combined with Asolectin Glycerosomes.

Front Pharmacol..， 2018； 9：38

DOI:10.3389/fphar.2018.00038

Suzuki Y, Ogasawara T, Tanaka Y, Takeda H, Sawasaki T, Mogi M, Liu S, Maeyama K.

Original paper Engineered membrane protein antigens successfully induce antibodies against extracellular regions of claudin-5.

Scientific Reports.， 2018； 8：8383

DOI:10.1038/s41598-018-26560-9

Yosuke Hashimoto, Wei Zhou, Kohtaroh Hamauchi, Keisuke Shirakura, Takefumi Doi, Kiyohito Yagi, Tatsuya Sawasaki, Yoshiaki Okada, Masuo Kondoh, Hiroyuki Takeda

Original paper Progress toward a transmission-blocking vaccine against malaria

Lancet Infect Dis..， 2018； 18：927-928

DOI:10.1016/S1473-3099(18)30358-X

Ishino T, Tsuboi T

Original paper Plasmodium falciparum Exported Protein 1 is localized to dense granules in merozoites

Parasitol Int..， 2018； 67：637-639

DOI:10.1016/j.parint.2018.06.001

Iriko H, Ishino T, Otsuki H, Ito D, Tachibana M, Torii M, Tsuboi T

Original paper Characterization of Plasmodium berghei Pbg37 as Both a Pre- and Postfertilization Antigen with Transmission-Blocking Potential

Infect Immun..， 2018； 86：e00785-17

DOI:10.1128/IAI.00785-17

Liu F, Li L, Zheng W, He Y, Wang Y, Zhu X, Tsuboi T, Cui L, Wang M, Cao Y

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