Achievements

Original paper The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD.

J Biol Chem..， 2019； 294：14135-14148

DOI:10.1074/jbc.RA119.010119

Uematsu A, Kido K, Takahashi H, Takahashi C, Yanagihara Y, Saeki N, Yoshida S, Maekawa M, Honda M, Kai T, Shimizu K, Higashiyama S, Imai Y, Tokunaga F, Sawasaki T.

Original paper Histone H3K27 demethylase negatively controls the memory formation of antigen-stimulated CD8+ T cells.

J Immunol.， 2019； 202：1088-1098

DOI:10.4049/jimmunol.1801083

Yamada T, Nabe S, Toriyama K, Suzuki J, Inoue K, Imai Y, Shiraishi A, Takenaka K, Yasukawa M, Yamashita M

Original paper Safe childbirth for a type 1 antithrombin-deficient woman with novel mutation in the SERPINC1 gene undergoing antithrombin concentrate therapy.

Blood Coagul Fibrinolysis.， 2019； 30：47-51

DOI:10.1097/MBC.0000000000000785

Ikeda Y, Yamanouchi J, Hato T, Yasukawa M, Takenaka K

Original paper Direct comparison of target-reactivity and cross-reactivity induced by CAR- and BiTE-redirected T cells for the development of antibody-based T-cell therapy.

Sci Rep.， 2019； 9：13293

DOI:10.1038/s41598-019-49834-2

Maruta M, Ochi T, Tanimoto K, Asai H, Saitou T, Fujiwara H, Imamura T, Takenaka K, Yasukawa M.

Original paper Purification and Biochemical Characterization of Cysteine Protease from Baby Kiwi (Actinidia arguta).

Open Biochem. J..， 2019； 13：54-63

DOI:10.2174/1874091X01913010054

Miyazaki-Katamura S, Yoneta-Wada M, Kozuka M , Sakaue T, Yamane T, Suzuki J, Arakawa Y, Ohkubo I.

Original paper Recent Insights into Long Bone Development: Central Role of Hedgehog Signaling Pathway in Regulating Growth Plate

Int. J. Mol. Sci..， 2019； 20(23)：5840

DOI:10.3390/ijms20235840

Haraguchi R, Kitazawa R, Kohara Y, Ikedo A, Imai Y, Kitazawa S.

Original paper Fibroblast Growth Factor 9 Is Upregulated Upon Intervertebral Mechanical Stress-Induced Ligamentum Flavum Hypertrophy in a Rabbit Model.

Spine..， 2019； 44(20)：E1172-E1180

DOI:10.1097/BRS.0000000000003089

Hayashi K, Suzuki A, Terai H, Ahmadi SA, Rahmani MS, Hasib MM, Habibi H, Hori Y, Yamada K, Hoshino M, Toyoda H, Takahashi S, Tamai K, Ohyama S, Imai Y, Nakamura H.

Original paper Mutation of the start codon to enhance Cripavirus internal ribosome entry site-mediated translation in a wheat germ extract

Bioorg. Med. Chem. Lett..， 2019； 29：126729

DOI:10.1016/j.bmcl.2019.126729

Ogawa A, Takamatsu M

Original paper Enforced expression of phosphatidylinositol 4-phosphate 5-kinase homolog alters PtdIns(4,5)P2 distribution and the localization of small G-proteins.

Sci. Rep..， 2019； 9：14789

DOI:10.1038/s41598-019-51272-z

Yang Y, Park M, Maekawa M, Fairn GD.

Original paper Genomic analysis of Hepatitis B virus and its association with disease manifestations in Bangladesh.

PLoS One..， 2019； 14：e0218744.

DOI:10.1371/journal.pone.0218744. eCollection 2019

Raihan R, Akbar SMF, Al Mahtab M, Takahashi K, Masumoto J, Tabassum S, Tee KK, Binti Mohamed R.

Original paper High possibility of hepatocarcinogenesis in HBV genotype C1 infected Cambodians is indicated by 340 HBV C1 full-genomes analysis from GenBank.

Sci Rep..， 2019； 9：12186

DOI:doi: 10.1038/s41598-019-48304-z

Chuon C, Takahashi K, Matsuo J, Katayama K, Yamamoto C, Ko K, Hok S, Nagashima S, Akbar SMF, Tanaka J

Original paper Hepatitis B core-related antigen (HBcrAg): an alternative to HBV DNA to assess treatment eligibility in Africa.

Clin Infect Dis..， 2019； Epub ahead of print：Epub ahead of print

DOI:doi: 10.1093/cid/ciz412

Shimakawa Y, Ndow G, Njie R, Njai HF, Takahashi K, Akbar SMF, Cohen D, Nayagam S, Jeng A, Ceesay A, Sanneh B, Baldeh I, Imaizumi M, Moriyama K, Aoyagi K, D'Alessandro U, Mishiro S, Chemin I, Mendy M, Thursz MR, Lemoine M.

Original paper Proton release process during the S2-to-S3 transition of photosynthetic water oxidation as revealed by the pH dependence of kinetics monitored by time-resolved infrared spectroscopy

Biochemistry.， 2019； 58：4276-4283

DOI:10.1021/acs.biochem.9b00680

Takemoto, H., Sugiura, M., and Noguchi, T.

Original paper Malaria vaccine candidates displayed on novel virus-like particles are immunogenic and induce transmission-blocking activity

PLoS One.， 2019； 14：e0221733

DOI:10.1371/journal.pone.0221733

Chan JA, Wetzel D, Reiling L, Miura K, Drew DR, Gilson PR, Anderson DA, Richards JS, Long CA, Suckow M, Jenzelewski V, Tsuboi T, Boyle MJ, Piontek M, Beeson JG

Original paper Deletion of Plasmodium falciparum Protein RON3 Affects the Functional Translocation of Exported Proteins and Glucose Uptake

MBio.， 2019； 10：e01460-19

DOI:10.1128/mBio.01460-19

Low LM, Azasi Y, Sherling ES, Garten M, Zimmerberg J, Tsuboi T, Brzostowski J, Mu J, Blackman MJ, Miller LH

Original paper Adeno-associated virus as an effective malaria booster vaccine following adenovirus priming

Front Immunol.， 2019； 10：730

DOI:10.3389/fimmu.2019.00730

Yusuf Y, Yoshii T, Iyori M, Yoshida K, Mizukami H, Fukumoto S, Yamamoto DS, Alam A, Emran TB, Amelia F, Islam A, Otsuka H, Takashima E, Tsuboi T, Yoshida S

Original paper Genomic and biological features of Plasmodium falciparum resistance against antimalarial endoperoxide N-89

Gene.， 2019； 716：144016

DOI:10.1016/j.gene.2019.144016

Morita M, Hayashi K, Sato A, Hiramoto A, Kaneko O, Isogawa R, Kurosaki Y, Miyoshi SI, Chang KS, Wataya Y, Kim HS

Original paper PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation.

Nat Commun..， 2019； 10：1844

DOI:10.1038/s41467-019-09867-7

Miyakawa K, Matsunaga S, Yokoyama M, Nomaguchi M, Kimura Y, Nishi M, Kimura H, Sato H, Hirano H, Tamura T, Akari H, Miura T, Adachi A, Sawasaki T, Yamamoto N, Ryo A.

Original paper Biophysical characterization of the breast cancer-related BIG3-PHB2 interaction: Effect of non-conserved loop region of BIG3 on the structure and the interaction.

Biochem Biophys Res Commun..， 2019； 518：183-189

DOI:10.1016/j.bbrc.2019.08.028

Chigira T, Nagatoishi S, Takeda H, Yoshimaru T, Katagiri T, Tsumoto K.

Original paper Expression and Localization Profiles of Rhoptry Proteins in Plasmodium berghei Sporozoites.

Front Cell Infect Microbiol..， 2019； 9：316

DOI:doi: 10.3389/fcimb.2019.00316

Tokunaga N, Nozaki M, Tachibana M, Baba M, Matsuoka K, Tsuboi T, Torii M, Ishino T.

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