Achievements

Original paper Active aneurysm thrombosis after Kawasaki disease in an adult: Insight into anticoagulation therapy

J Cardiol Cases..， 2021； 23(5)：206-209.

DOI:10.1016/j.jccase.2020.11.005

Akazawa Y, Inaba S, Sakaue T, Kurata M, Aono J, Yasugi T, Moritani T, Nishiyama H, Higaki T, Eguchi M, Yamaguchi O.

Original paper Functionally confirmed compound heterozygous ADAM17 missense loss-of-function variants cause neonatal inflammatory skin and bowel disease 1

Sci Rep..， 2021； 11：9552

DOI:10.1038/s41598-021-89063-0

Imoto I, Saito M, Suga K, Kohmoto T, Otsu M, Horiuchi K, Nakayama H, Higashiyama S, Sugimoto M, Sasaki A, Homma Y, Shono M, Nakagawa R, Hayabuchi Y, Tange S, Kagami S, Masuda K

Original paper Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4

iScience..， 2021； 24(4)：102303

DOI:10.1016/j.isci.2021.102303

Sakakibara I, Yanagihara Y, Himori K, Yamada T, Sakai H, Sawada Y, Takahashi H, Saeki N, Hirakawa H, Yokoyama A, Fukada S, Sawasaki T, Imai Y.

Original paper Molecular detection using aptamer-modified gold nanoparticles with an immobilized DNA brush for the prevention of non-specific aggregation

RSC Adv..， 2021； 11：11984-11991

DOI:10.1039/D0RA05149G

Yano-Ozawa Y, Lobsiger N, Muto Y, Mori T, Yoshimura K, Yano Y, Stark WJ, Maeda M, Asahi T, Ogawa A, Zako T

Original paper Topical co-administration of zoledronate with recombinant human bone morphogenetic protein-2 can induce and maintain bone formation in the bone marrow environment

BMC Musculoskelet Disord..， 2021； 22(1)：94

DOI:10.1186/s12891-021-03971-w

Ueyama H, Ohta Y, Imai Y, Suzuki A, Sugama R, Minoda Y, Takaoka K, Nakamura H.

Original paper A single-chain antibody generation system yielding CAR-T cells with superior antitumor function

Communications Biology.， 2021； 4：Article number 273

DOI:10.1038/s42003-021-01791-1

Toshiki Ochi, Masaki Maruta, Kazushi Tanimoto, Fumitake Kondo, Toshihiro Yamamoto, Mie Kurata, Hiroshi Fujiwara, Junya Masumoto, Katsuto Takenaka, Masaki Yasukawa

Original paper Roles of Pyk2 in signal transduction after gonadotropin‐releasing hormone receptor stimulation.

J. Cell. Physiol..， 2021； 236(4)：3033-3043.

DOI:10.1002/jcp.30077

Okitsu-Sakurayama S, Higa-Nakamine S, Torihara H, Higashiyama S, Yamamoto H

Original paper Thalidomide and its metabolite 5‐hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF

EMBO J.， 2021；：e105375

DOI:10.15252/embj.2020105375

Satoshi Yamanaka, Hidetaka Murai, Daisuke Saito, Gembu Abe, Etsuko Tokunaga, Takahiro Iwasaki, Hirotaka Takahashi, Hiroyuki Takeda, Takayuki Suzuki, Norio Shibata, Koji Tamura, Tatsuya Sawasaki

Original paper Pathological Evidence of Native Aortic Valve Injury After Impella Support.

Circ Heart Fail..， 2021； 14(2)：e007571

DOI:10.1161/CIRCHEARTFAILURE.120.007571

Higashi H, Nishimura T, Aono J, Sakaue T, Kurata M, Izutani H, Yamaguchi O

Original paper Protective Effect of Ferulic Acid against Hydrogen Peroxide Induced Apoptosis in PC12 Cells

Molecules..， 2020； 26(1)：E90

DOI:10.3390/molecules26010090

Nakayama H, Nakahara M, Matsugi E, Soda M, Hattori T, Hara K, Usami A, Kusumoto C, Higashiyama S, Kitaichi K.

Original paper Polyamine pathway is associated with muscle anabolic effects by androgen receptor ligand

JCSM Rapid Commun..， 2021； 4(1)　：57-74

DOI:10.1002/rco2.28

Kanou M, Nakamura K, Horie K, Sakai H, Yanagihara Y, Sakakibara I, Yamana K, Imai Y.

Original paper DNA maintenance methylation enzyme Dnmt1 in satellite cells is essential for muscle regeneration

Biochem Biophys Res Commun..， 2021； 534：79-85

DOI:10.1016/j.bbrc.2020.11.116

Iio H, Kikugawa T, Sawada Y, Sakai H, Yoshida S, Yanagihara Y, Ikedo A, Saeki N, Fukada S, Saika T, Imai Y.

Original paper Reprogramming of synovial macrophage metabolism by synovial fibroblasts under inflammatory conditions

Cell Commun Signal..， 2020； 18(1)：188

DOI:10.1186/s12964-020-00678-8

Saeki N, Imai Y.

Original paper Teadenol A in microbial fermented tea acts as a novel ligand on GPR120 to increase GLP-1 secretion.

Food Funct..， 2020； 11(12)：10534-10541

DOI:10.1039/d0fo02442b

Nagasawa T, Ishimaru K, Higashiyama S, Hama Y, Mitsutake S.

Original paper ANKFY1 is essential for retinal endothelial cell proliferation and migration via VEGFR2/Akt/eNOS pathway

Biochem. Biophys. Res. Commun..， 2020； 533 (4)：1406-1412

DOI:10.1016/j.bbrc.2020.10.032

Tanaka M, Nakamura S, Maekawa M, Higashiyama S, Hara H.

Original paper In Vitro Selection of RNA Aptamers Binding to Nanosized DNA for Constructing Artificial Riboswitches

ACS Synth. Biol..， 2020； 9：2648–2655

DOI:10.1021/acssynbio.0c00384

Ogawa A, Itoh Y

Original paper A novel MRGPRX2-targeting antagonistic DNA aptamer inhibits histamine release and prevents mast cell-mediated anaphylaxis.

Eur J Pharmacol..， 2020； 878：173104

DOI:10.1016/j.ejphar.2020.173104

Suzuki Y, Liu S, Ogasawara T, Sawasaki T, Takasaki Y, Yorozuya T, Mogi M.

Original paper Soy and Arabidopsis receptor-like kinases respond to polysaccharide signals from Spodoptera species and mediate herbivore resistance.

Commun Biol..， 2020； 3：224

DOI:10.1038/s42003-020-0959-4

Uemura T, Hachisu M, Desaki Y, Ito A, Hoshino R, Sano Y, Nozawa A, Mujiono K, Galis I, Yoshida A, Nemoto K, Miura S, Nishiyama M, Nishiyama C, Horito S, Sawasaki T, Arimura GI.

Original paper AirID, a novel proximity biotinylation enzyme, for analysis of protein-protein interactions.

eLife.， 2020； 9：e54983

DOI:10.7554/eLife.54983

Kido K, Yamanaka S, Nakano S, Motani K, Shinohara S, Nozawa A, Kosako H, Ito S, Sawasaki T.

Original paper A human DUB protein array for clarification of linkage specificity of polyubiquitin chain and application to evaluation of its inhibitors.

Biomedicines..， 2020； 8：E152

DOI:10.3390/biomedicines8060152

Takahashi H*, Yamanaka S, Kuwada S, Higaki K, Kido K, Sato Y, Fukai S, Tokunaga F, and Sawasaki T*.

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