Achievements

Original paper (日本語) Inflammasome assembly is required for intracellular formation of β2-microglobulin amyloid fibrils, leading to IL-1β secretion.

Int J Immunopathol Pharmacol..， 2022； 36：3946320221104554

DOI:10.1177/03946320221104554

Kaneko N, Mori W, Kurata M, Yamamoto T, Zako T, Masumoto J.

Original paper (日本語) Expert perspectives on pathological findings in vasculitis.

Mod Rheumatol..， 2023； 33：1-11

DOI:10.1093/mr/roac043

Ishizu A, Kawakami T, Kanno H, Takahashi K, Miyazaki T, Ikeda E, Oharaseki T, Ogawa Y, Onimaru M, Kurata M, Nakazawa D, Muso E, Harigai M.

Original paper (日本語) Expression of factor XIII originating from synovial fibroblasts and macrophages induced by interleukin-6 signaling.

Inflamm Regen..， 2023； 43：2

DOI:10.1186/s41232-022-00252-4

Watanabe H, Mokuda S, Tokunaga T, Kohno H, Ishitoku M, Araki K, Sugimoto T, Yoshida Y, Yamamoto T, Matsumoto M, Masumoto J, Hirata S, Sugiyama E.

Original paper (日本語) Prognostic impact of SLFN11 in bladder cancer patients treated with DNA-damaging agent

Cancer Science.， 2022； 113：784-795

DOI:10.1111/cas.15207

Daiki Taniyama, Naoya Sakamoto*, Tsuyoshi Takashima, Masahiko Takeda, Quoc Thang Pham, Shoichi Ukai, Ryota Maruyama, Kenji Harada, Takashi Babasaki, Yohei Sekino, Tetsutaro Hayashi, Kazuhiro Sentani, Yves Pommier, Junko Murai, Wataru Yasui

Original paper (日本語) Epigenetic upregulation of Schlafen11 renders WNT- and SHH- activated medulloblastomas sensitive to cisplatin

Neuro-Oncology.， 2022； 25：899-912

DOI:10.1093/neuonc/noac243

Satoshi Nakata, Junko Murai, Masayasu Okada, Haruhiko Takahashi, Tyler H. Findlay, Kristen Malebranche, Akhila Parthasarathy, Satoshi Miyashita, Ramil Gabdulkhaev, Ilan Benkimoun, Sabine Druillennec, Sara Chabi, Eleanor Hawkins, Hiroaki Miyahara, Kensuke Tateishi, Shinji Yamashita; Shiori Yamada, Taiki Saito, Jotaro On, Jun Watanabe, Yoshihiro Tsukamoto, Junichi Yoshimura, Makoto Oishi, Toshimichi Nakano, Masaru Imamura, Chihaya Imai, Tetsuya Yamamoto, Hideo Takeshima; Atsuo T. Sasaki, Fausto J Rodriguez, Sumihito Nobusawa, Pascale Varlet, Celio Pouponnot, Satoru Osuka, Yves Pommier, Akiyoshi Kakita, Yukihiko Fujii, Eric H. Raabe, Charles G Eberhart, Manabu Natsumeda

Original paper (日本語) Nuclear AREG affects a low-proliferative phenotype and contributes to drug resistance of melanoma.

Int J Cancer. .， 2022； 151：2244-2264

DOI:10.1002/ijc.34254

Seefried F, Haller L, Fukuda S, Thongmao A, Schneider N, Utikal J, Higashiyama S, Bosserhoff AK, Kuphal S.

Original paper (日本語) O-ring-induced transverse aortic constriction (OTAC) is a new simple method to develop cardiac hypertrophy and heart failure in mice.

Sci Rep. .， 2022； 12：85

DOI:10.1038/s41598-021-04096-9

Nakao Y, Aono J, Hamaguchi M, Takahashi K, Sakaue T, Inoue K, Ikeda S, Yamaguchi O.

Original paper (日本語) Inactivation of axon guidance molecule netrin-1 in human colorectal cancer by anepigenetic mechanism.

Biochem Biophys Res Commun. .， 2022； 611：146-150

DOI:10.1016/j.bbrc.2022.04.069

Nakayama H, Ohnuki H, Nakahara M, Nishida-Fukuda H, Sakaue T, Fukuda S, Higashiyama S, Doi Y, Mitsuyoshi M, Okimoto T, Tosato G, Kusumoto C.

Original paper (日本語) Functional Blockage of S100A8/A9 Ameliorates Ischemia-Reperfusion Injury in the Lung.

Bioengineering (Basel)..， 2022； 9：673.

DOI:10.3390/bioengineering9110673

Nakata K, Okazaki M, Sakaue T, Kinoshita R, Komoda Y, Shimizu D, Yamamoto H, Tanaka S, Suzawa K, Shien K, Miyoshi K, Yamamoto H, Ohara T, Sugimoto S, Yamane M, Matsukawa A, Sakaguchi M, Toyooka S.

Original paper (日本語) LOX-1 deficiency increases ruptured abdominal aortic aneurysm via thinning of adventitial collagen

Hypertens Res..， 2023； 46：63-74

DOI:10.1038/s41440-022-01093-x

Takahashi K, Aono J, Nakao Y, Hamaguchi M, Suehiro C, Kurata M, Sakaue T, Kakino A, Sawamura T, Inoue K, Ikeda S, Suzuki J, Yamaguchi O.

Original paper (日本語) Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21.

Commun Biol. .， 2023； 6：(1):13.

DOI:10.1038/s42003-022-04408-3

Muto J, Fukuda S, Watanabe K, Dai X, Tsuda T, Kiyoi T, Kameda K, Kawakami R, Mori H, Shiraishi K, Murakami M, Imamura T, Higashiyama S, Fujisawa Y, Mizukami Y, Sayama K.

Original paper Energetics and proton release in Photosystem II from Thermosynechococcus elongatus with a D1 protein encoded by either the psbA2 or psbA3 gene

Biochim. Biophys. Acta (Bioenergetics).， 2023； 1864：148979

DOI:10.1016/j.bbabio.2023.148979

Boussac, A., Sellés, J., and Sugiura, M.

Original paper LIM1 contributes to the malignant potential of endometrial cancer

Front. Oncol..， 2023； 13：1082441

DOI:10.3389/fonc.2023.1082441

Kato H, Saeki N, Imai M, Onji H, Yano A, Yoshida Y, Sakaue T, Fujioka T, Sugiyama T, Imai Y.

Original paper Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

J Vis Exp..， 2023； 192：e65196

DOI:10.3791/65196

Saeki N, Imai Y.

Original paper (日本語) Intestinal edema induced by LPS-induced endotoxemia is associated with an inflammasome adaptor ASC

PLOS ONE.， 2023； 18(2)：e0281746

DOI:10.1371/journal.pone.0281746

Toshihiro Yamamoto, Mie Kurata, Naoe Kaneko, Junya Masumoto

Original paper Facile Expansion of the Variety of Orthogonal Ligand/Aptamer Pairs for Artificial Riboswitches

ACS Synth. Biol..， 2023； 12：35-42

DOI:10.1021/acssynbio.2c00475

Ogawa A, Inoue H, Itoh Y, Takahashi H

Original paper (日本語) Toll-like receptor 4 promotes bladder cancer progression upon S100A8/A9 binding, which requires TIRAP-mediated TPL2 activation

Biochem Biophys Res Commun.， 2022； 634：83-91

DOI:10.1016/j.bbrc.2022.09.116

Herik Rodrigo AG, Tomonobu N, Yoneda H, Kinoshita R, Mitsui Y, Sadahira T, Terawaki SI, Gohara Y, Gede Yoni Komalasari NL, Jiang F, Murata H, Yamamoto KI, Futami J, Yamauchi A, Kuribayashi F, Inoue Y, Kondo E, Toyooka S, Nishibori M, Watanabe M, Nasu Y, Sakaguchi M.

Original paper CF-PPiD technology based on cell-free protein array and proximity biotinylation enzyme for in vitro direct interactome analysis

Sci Rep.， 2022； 12(1)：10592

DOI:10.1038/s41598-022-14872-w

Sugiyama S, Yamada K, Denda M, Yamanaka S, Ozawa S, Morishita R, Sawasaki T.

Original paper OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways

Cell Death Dis.， 2022； 13(8)：694

DOI:10.1038/s41419-022-05145-5

Oikawa D, Gi M, Kosako H, Shimizu K, Takahashi H, Shiota M, Hosomi S, Komakura K, Wanibuchi H, Tsuruta D, Sawasaki T, Tokunaga F.

Original paper A simple method for labeling proteins and antibodies with biotin using the proximity biotinylation enzyme TurboID

Biochem Biophys Res Commun.， 2022； 592：54-59

DOI:10.1016/j.bbrc.2021.12.109

Shioya R, Yamada K, Kido K, Takahashi H, Nozawa A, Kosako H, Sawasaki T.

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