To the Future with
PROTEO-SCIENCE

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ABOUT PROS

Proteins are the building blocks of life. The wheat cell-free protein synthesis method, pioneered here at PROS, enables the high-throughput, large scale synthesis of high quality proteins.

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PRiME

PRiME is a joint-use, collaborative research center focusing on interactome analysis set up by the Proteo-Science Center at Ehime University.
Collaborative research is the bedrock of our center, and we are continuously adapting our program to facilitate our ability to work together with researchers all over the world.

DEPARTMENTS

The Proteo-Science Center at Ehime University consists of various diverse research departments affiliated with 'Fundamental Technology Development‘ and 'Complex Bioscience Analysis’. We aim to promote protein-based life science research, and to use our expertise to inform the development of novel diagnostics and therapeutics for the improvement of human health.

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ACHIEVEMENTS

Original paper The androgen receptor in mesenchymal progenitors regulates skeletal muscle mass via Igf1 expression in male mice

Proc Natl Acad Sci U S A.., 2024; 121(39):e2407768121
DOI:10.1073/pnas.2407768121
Sakai H, Uno H, Yamakawa H, Tanaka K, Ikedo A, Uezumi A, Ohkawa Y, Imai Y.

Original paper Cell-Free Biosensors Based on Modular Eukaryotic Riboswitches That Function in One Pot at Ambient Temperature

ACS Synth. Biol.., 2024; 13:2238-2245
DOI:10.1021/acssynbio.4c00341
Atsushi Ogawa, Masahiro Fujikawa, Kazuki Onishi, Hajime Takahashi

Original paper KIF22 regulates mitosis and proliferation of chondrocyte cells

iScience.., 2024; 27(7):110151
DOI:10.1016/j.isci.2024.110151
Kawaue H, Matsubara T, Nagano K, Ikedo A, Rojasawasthien T, Yoshimura A, Nakatomi C, Imai Y, Kakuta Y, Addison WN, Kokabu S.

Original paper Rhodium-catalyzed homo-coupling reaction of aryl Grignard reagents and its application for the synthesis of an integrin inhibitor

The Beilstein Journal of Organic Chemistry., 2024; 20:1341-1347
DOI:10.3762/bjoc.20.118
Kazuyuki Sato, Satoki Teranishi, Atsushi Sakaue, Yukiko Karuo, Atsushi Tarui, Kentaro Kawai, Hiroyuki Takeda, Tatsuo Kinashi and Masaaki Omote

Original paper CANE, a Component of the NLRP3 Inflammasome, Promotes Inflammasome Activation

The Journal of Immunology., 2024; 213:1-10
DOI:10.4049/jimmunol.2300175
Naoe Kaneko, Mie Kurata, Toshihiro Yamamoto, Akimasa Sakamoto, Yasutsugu Takada, Hidetaka Kosako, Hiroyuki Takeda, Tatsuya Sawasaki, Junya Masumoto