Cell-free based protein array

To the Future with
PROTEO-SCIENCE

INFORMATION

2024.01.19

ACADEMIC

Malaria Research

PROS Seminar (February 6th 2024)
2023.10.25

ACADEMIC

Parasitology

PROS Seminar (November 6th 2023)
2023.06.29

RESEARCH

Nature Outlook “Malaria” featured a branded content article on malaria research.

ABOUT PROS

Proteins are the building blocks of life. The wheat cell-free protein synthesis method, pioneered here at PROS, enables the high-throughput, large scale synthesis of high quality proteins.

PRiME is a joint-use, collaborative research center focusing on interactome analysis set up by the Proteo-Science Center at Ehime University.
Collaborative research is the bedrock of our center, and we are continuously adapting our program to facilitate our ability to work together with researchers all over the world.

DEPARTMENTS

The Proteo-Science Center at Ehime University consists of various diverse research departments affiliated with 'Fundamental Technology Development‘ and 'Complex Bioscience Analysis’. We aim to promote protein-based life science research, and to use our expertise to inform the development of novel diagnostics and therapeutics for the improvement of human health.

ACHIEVEMENTS

Original paper Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease

Nat Genet..， 2026； 58(7)：1530-1545

DOI:10.1038/s41588-026-02640-9

Chai RC, Lundberg M, Freudenthal B, Smith JT, Boughton AP, Zhang Y, Flynn KA, Frysz M, Corr AP, Khoo WH, Komla-Ebri D, Dack MRG, Guilfoyle SE, Logan JG, Butterfield NC, Leitch VD, Pollard AS, Mäkitie RE, Bradford N, Ramos-Mucci L, Vilas-Zornoza A, Chen Y, Yip RKH, Er J, Tan SZ, McDonald MM, Youlten SE, Sergio CM, Castro-Martinez A, Young SG, Skorokhodova E, Evans DM, Powell JE, de Leeuw CA, Ewing AD, Eisman JA, Blank RD, Phan TG; International Federation of Musculoskeletal Research Societies (IFMRS) Big Data Working Group; Lagendijk AK, Hawkins ED, Oh HL, McIntyre RE, Hessel EM, Taylor-King JP, Baldock PA, Duncan EL, Williams GR, Bassett JHD, Croucher PI, Kemp JP.

Original paper S100A4-TLR4-TGF-β axis as a therapeutic target for Dupuytren’s contracture in diabetic patients

Cell Death Discov..， 2026； 12：310

DOI:10.1038/s41420-026-03167-y

Kato K, Komura S, Yanagihara Y, Saeki N, Goto A, Maki R, Hirose H, Hirakawa A, Imai Y, Akiyama H.

Original paper Ldha Regulates Osteosarcoma Lung Metastasis through Hedgehog Signaling

Cancer Res Commun..， 2026； 6(6)：1495-1508

DOI:10.1158/2767-9764.CRC-25-0163

Maki R, Komura S, Nagano A, Niwa A, Tomita H, Imai Y, Akiyama H.

Original paper A pleckstrin homology domain protein is involved in crystalloid formation in Plasmodium ookinetes and affects the maturation of infective sporozoites

oop Logo Frontiers in Cellular and Infection Microbiology.， 2026； 16：2026

DOI:10.3389/fcimb.2026.1777159

Mayumi Tachibana, Naoaki Shinzawa, Minami Baba, Motomi Torii, Richard Culleton, Tomoko Ishino

Original paper UNC45B Reduction With Aging: A Myofiber-Intrinsic Promoting Factor for Sarcopenia

Aging Cell..， 2026； 25(5)：e70502

DOI:10.1111/acel.70502

Mishima T, Nagamune T, Tada S, Watanabe D, Tokuda N, Yamada T, Hashimoto-Hachiya A, Higo-Yamamoto S, Kido K, Nagaoka N, Ikedo A, Imai Y, Fujita R, Mizuno S, Takahashi S, Oishi K, Ato S, Ogasawara R.

To the Future withPROTEO-SCIENCE