Cell-free based protein array

To the Future with
PROTEO-SCIENCE

INFORMATION

2024.01.19

ACADEMIC

Malaria Research

PROS Seminar (February 6th 2024)
2023.10.25

ACADEMIC

Parasitology

PROS Seminar (November 6th 2023)
2023.06.29

RESEARCH

Nature Outlook “Malaria” featured a branded content article on malaria research.

ABOUT PROS

Proteins are the building blocks of life. The wheat cell-free protein synthesis method, pioneered here at PROS, enables the high-throughput, large scale synthesis of high quality proteins.

PRiME is a joint-use, collaborative research center focusing on interactome analysis set up by the Proteo-Science Center at Ehime University.
Collaborative research is the bedrock of our center, and we are continuously adapting our program to facilitate our ability to work together with researchers all over the world.

DEPARTMENTS

The Proteo-Science Center at Ehime University consists of various diverse research departments affiliated with 'Fundamental Technology Development‘ and 'Complex Bioscience Analysis’. We aim to promote protein-based life science research, and to use our expertise to inform the development of novel diagnostics and therapeutics for the improvement of human health.

ACHIEVEMENTS

Original paper CDH11 contributes to bladder cancer progression via regulation of mitochondrial energy metabolism

Cancer Med..， 2025； 1：1

DOI:

Arai O, Yanagihara Y, Arai H, Watanabe R, Miura N, Kikugawa T, Saika T, Imai Y.

Original paper Estrogen signaling in PDGFRα+ cells positively regulates cortical bone metabolism via IGFBP5 in female mice

JBMR Plus..， 2025； 1：ziaf178

DOI:10.1093/jbmrpl/ziaf178

Ikedo A, Aoki R, Sakai H, Saeki N, Yanagihara Y, Moody J, Kojima M, Kouno T, Ando Y, Hino K, Kinoshita T, Carninci P, Shin JW, Hon CC, Uezumi A, Kamei Y, Imai Y.

Original paper Claudin 5-binding small molecule transiently opens the blood-brain barrier and safely enhances brain drug delivery

J Control Release.， 2025； 388：114314

DOI:10.1016/j.jconrel.2025.114314

Saito Inoue, Keisuke Shirakura, Atsuya Shirono, Jumpei Taguchi, Yoshiki Ikeda, Satomi Tomita, Risa Funatsu, Kosuke Muraoka, Yosuke Hashimoto, Keisuke Tachibana, Nobumasa Hino, Takefumi Doi, Yui Ikemi, Kazuto Nunomura, Bangzhong Lin, Shinsaku Nakagawa, Kazutake Tsujikawa, Shota Tanaka, Masanori Obana, Yasushi Fujio, Takamitsu Hosoya, Hiroyuki Takeda, Masuo Kondoh, Yoshiaki Okada

Original paper (日本語) Size-selective permeation-enhancing modulation of the tight junction by receptor-binding domains of Clostridium perfringens enterotoxin and Clostridium perfringens iota-toxin

Tissue Barriers.， 2025； 13：2459963

DOI:10.1080/21688370.2025.2459963

Size-selective permeation-enhancing modulation of the tight junction by receptor-binding domains of Clostridium perfringens enterotoxin and Clostridium perfringens iota-toxin

Original paper Structural basis of the hepatitis B virus X protein in complex with DDB1

Proc Natl Acad Sci U S A.， 2025； 122：e2421325122

DOI:10.1073/pnas.2421325122

Hiroki Tanaka, Joao Diogo Dias, Basile Jay, Shunsuke Kita, Mina Sasaki, Hiroyuki Takeda, Naoki Kishimoto, Shunsuke Sasaki, Shogo Misumi 5, Masashi Mizokami, Christine Neuveut, Takashi Sumikama, Mikihiro Shibata, Katsumi Maenaka, Shinichi Machida

To the Future withPROTEO-SCIENCE