Director’s Message

Proteins are the fundamental building blocks of life. The wheat cell-free protein synthesis method, developed and commercialized by the Proteo-Science Center (PROS), allows the free synthesis of proteins at exceptional scale and quality. The wheat cell-free system is particularly effective in synthesizing the proteins of higher eukaryotes such as humans, as it utilizes the same main engine of protein synthesis (the ribosome). As in human society, most proteins function not in isolation, but through interactions with other proteins in complexes. The formation of complex proteins in the cell is an important regulatory mechanism for protein function, especially in higher organisms such as humans, and so understanding complex formation is of crucial importance. Since protein complexes function as switches for cell proliferation and responses, they may make excellent drug targets.
PROS is constructing a human protein array consisting of almost every human protein using wheat cell-free protein synthesis and is using this to identify interacting proteins. We are using this technology to search for drugs that inhibit protein-protein interactions.
In addition, we are using our unique resources to conduct research on a wide range of biological species, from cyanobacteria, malaria parasites, and cultured animal cells to higher plants such as Arabidopsis thaliana, animals such as mice, and humans. PROS is unique in that it has established a system that enables us to conduct integrated protein research by analyzing the chain of proteins, cells, and whole organisms, allowing us to conduct basic research and to develop medical applications such as novel diagnostics and therapeutics. We actively promote and develop joint research between our departments and research institutes and commercial companies worldwide. Thank you very much for your support.

センター長 澤崎 達也

Proteo-Science CenterDirector Tatsuya Sawasaki, PhD

About PROS

The Proteo-Science Center (PROS), Ehime University was established with the remit of understanding life through the use of cutting-edge wheat-germ cell-free protein synthesis technology. Furthermore, our center aims to discover novel treatments for cancer, infectious diseases, autoimmune diseases and so on.

The center consists of the 'Section for Fundamental Technology Development', which is responsible for the development of core technologies to support protein biochemistry and protein complex research, and the 'Section for Advanced Complex Biological Sciences', which promotes protein complex and interactome analyses in cells and living organisms, human diseases and infectious diseases.

The 'Section for Fundamental Technology Development' focuses on protein science research and is composed of eight divisions: Cell-free Science, Proteo-Drug-Discovery Science, Biomolecular Engineering, Super-Biomolecular Science, Structural Analysis of Protein Complexes, Bio-imaging, and Proteomics and Immune Regulation. The 'Section for Advanced Complex Biological Sciences' focuses on in vivo functional protein research and is composed of six divisions: Cell Growth and Tumor Regulation, Pathology, Integrative Pathophysiology, Parasitology, Malaria Research, and Proteo-Interactomics.

PROS promotes protein and protein complex-based life-science research in the fields of health, agriculture and fisheries.


April 1, 2003
The Cell-Free Science and Technology Research Center was established
April 1, 2009
The Proteo-Research Center was established
April 1, 2013
The Proteo- Science Center was established

Access and contact details

Johoku Station

Proteo- Science Center, Ehime University,
3 Bunkyo-cho, Matsuyama, Ehime 790-857, Japan
TEL:089-927-9686 / FAX:089-927-8528

Shigenobu Station

Proteo- Science Center, Ehime University,
Shitsukawa, Toon, Ehime 791-0295, Japan
TEL:089-960-5944 / FAX:089-960-5961