Proteins are the fundamental building blocks of life. The wheat cell-free protein synthesis method, developed and commercialized by the Proteo-Science Center (PROS), allows the free synthesis of proteins at exceptional scale and quality. The wheat cell-free system is particularly effective in synthesizing the proteins of higher eukaryotes such as humans, as it utilizes the same main engine of protein synthesis (the ribosome). As in human society, most proteins function not in isolation, but through interactions with other proteins in complexes. The formation of complex proteins in the cell is an important regulatory mechanism for protein function, especially in higher organisms such as humans, and so understanding complex formation is of crucial importance. Since protein complexes function as switches for cell proliferation and responses, they may make excellent drug targets.
PROS is constructing a human protein array consisting of almost every human protein using wheat cell-free protein synthesis and is using this to identify interacting proteins. We are using this technology to search for drugs that inhibit protein-protein interactions.
In addition, we are using our unique resources to conduct research on a wide range of biological species, from cyanobacteria, malaria parasites, and cultured animal cells to higher plants such as Arabidopsis thaliana, animals such as mice, and humans. PROS is unique in that it has established a system that enables us to conduct integrated protein research by analyzing the chain of proteins, cells, and whole organisms, allowing us to conduct basic research and to develop medical applications such as novel diagnostics and therapeutics. We actively promote and develop joint research between our departments and research institutes and commercial companies worldwide. Thank you very much for your support.
Proteo-Science CenterDirector Tatsuya Sawasaki, PhD