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英文原著 Schlafen 11 (SLFN11) kills cancer cells undergoing unscheduled re-replication

Molecular Cancer Therapeutics.， 2023； 22(8)：985-995

DOI:10.1158/1535-7163.MCT-22-0552

Junko Murai*, Michele Ceribelli, Haiqing Fu, Christophe E. Redon, Ukhyun Jo, Yasuhisa Murai, Mirit I. Aladjem, Craig J. Thomas, Yves Pommier*

英文原著 SLFN11 is a BRCA independent biomarker for the response to platinum-based chemotherapy in high-grade serous ovarian cancer and clear cell ovarian carcinoma.

Molecular Cancer Therapeutics.， 2023； 23(1)：106–116

DOI:10.1158/1535-7163.MCT-23-0257

Hidehiko Akashi, Nozomi Yachida, Haruka Ueda, Manako Yamaguchi, Kaoru Yamawaki, Ryo Tamura, Kazuaki Suda, Tatsuya Ishiguro, Sosuke Adachi, Yoshikazu Nagase, Yutaka Ueda, Masashi Ueda, Kaoru Abiko, Masahiro Kagabu, Tsukasa Baba, Hirofumi Nakaoka, Takayuki Enomoto, Junko Murai*, Kosuke Yoshihara*

英文原著 Aberrant accumulation of NIK promotes tumor growth by dysregulating translation and post-translational modifications in breast cancer.

Cancer Cell International.， 2023； 23：57

DOI:10.1186/s12935-023-02904-y

Hayashi Y, Nakayama J, Yamamoto M, Maekawa M, Watanabe S, Higashiyama S, Inoue JI, Yamamoto Y, Semba K

英文原著 Metabolic clogging of mannose triggers genomic instability via dNTP loss in human cancer cells

eLife.， 2023； 12：e83870

DOI:10.7554/eLife.83870

Harada Y, Mizote Y, Suzuki T, Nishida M, Hiratsuka T, Ueda A, Imagawa Y, Maeda K, Ohkawa Y, Murai M, Freeze H. H, Miyoshi E, Higashiyama S, Udono U, Dohmae N, Tahara H, Taniguchi N.

英文原著 SPOP is essential for DNA replication licensing through maintaining translation of CDT1 and CDC6 in HaCaT cells.

Biochemical and Biophysical Research Communications.， 2023； 651(9)：30-38

DOI:10.1016/j.bbrc.2023.02.012

Sanada S, Maekawa M, Tate S, Nakaoka H, Fujisawa Y, Sayama K, Higashiyama S.

英文原著 BCL6B Contributes to Ocular Vascular Diseases via Notch Signal Silencing

Arteriosclerosis, Thrombosis, and Vascular Biology.， 2023； 43：927-942

DOI:10.1161/ATVBAHA.123.318987

Tanaka M, Nakamura S, Sakaue T, Yamamoto T, Maekawa M, Nishinaka A, Yasuda H, Yunoki K, Sato Y, Sawa M, Yoshino K, Shimazawa M, Hatano M, Tokuhisa T, Higashiyama S, Hara H.

英文原著 Human TMEM2 is not a catalytic hyaluronidase, but a regulator of hyaluronan metabolism via HYBID (KIAA1199/CEMIP) and HAS2 expression.

Journal of Biological Chemistry.， 2023； 299：104826

DOI:10.1016/j.jbc.2023.104826

Sato S, Miyazaki M, Fukuda S, Mizutani Y, Mizukami Y, Higashiyama S, Inoue S

英文原著 Reply: Low-Grade Inflammation: A Familiar Factor in Cardiovascular Diseases

JACC: Basic to Translational Science.， 2023； 8 (11)：1476

DOI:10.1016/j.jacbts.2023.09.009

Sakaue T and Izutani H

英文原著 Wnt activation disturbs cell competition and causes diffuse invasion of transformed cells through NF-κB-MMP21 pathway

Nature Communications.， 2023； 14：7048

DOI:10.1038/s41467-023-42774-6

Nakai K, Lin H, Yamano S, Tanaka S, Kitamoto S, Saitoh H, Sakuma K, Kurauchi J, Akter E, Konno M, Ishibashi K, Kamata R, Ohashi A, Koseki J, Takahashi H, Yokoyama H, Shiraki Y, Enomoto A, Abe S, Hayakawa Y, Ushiku T, Mutoh M, Fujita Y, Kon S.

英文原著 Utility of synthetic MRI in predicting pathological complete response of various breast cancer subtypes prior to neoadjuvant chemotherapy

Clin Radiol..， 2022； 2022 Aug 30：S0009-9260(22)00328-2

DOI:10.1016/j.crad.2022.06.019

M.Matsuda, N.Fukuyama, T.Matsuda, S.Kikuchi, Y.Shiraishi, Y.Takimoto, Y.Kamei, M.Kurata, R.Kitazawa, T.Kido

英文原著 Triple-negative breast cancer on contrast-enhanced MRI and synthetic MRI: A comparison with non-triple-negative breast carcinoma

Eur J Radiol.， 2022； Sep;142：109838

DOI:10.1016/j.ejrad.2021.109838

Megumi Matsuda, Takaharu Tsuda, Rui Ebihara, Wataru Toshimori, Kanako Okada, Shiori Takeda, Aya Okumura, Yasuhiro Shiraishi, Hiroshi Suekuni, Yoshiaki Kamei, Mie Kurata, Riko Kitazawa, Teruhito Mochizuki, Teruhito Kido

英文原著 Synthesis and photophysical properties of a new push–pull pyrene dye with green-to-far-red emission and its application to human cellular and skin tissue imaging

Journal of Materials Chemistry B.， 2022； 10：1641-1649

DOI:10.1039/D1TB02728J

Kazuki Inoue, Ryosuke Kawakami, Masamoto Murakami, Taku Nakayama, Shinkuro Yamamoto, Keiji Inoue, Teruko Tsuda, Koji Sayama, Takeshi Imamura, Daisuke Kaneno, Shingo Hadano, Shigeru Watanabe and Yosuke Niko

英文原著 TGFβ selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial–mesenchymal transition

Molecular Oncology.， 2022； 16(12)：2330-2354

DOI:10.1002/1878-0261.13215

Yutaro Tsubakihara, Yae Ohata, Yukari Okita, Shady Younis, Jens Eriksson, Mikael E. Sellin, Jiang Ren, Peter ten Dijke, Kohei Miyazono, Atsuhiko Hikita, Takeshi Imamura, Mitsuyasu Kato, Carl-Henrik Heldin, Aristidis Moustakas

英文原著 Tumor-targeted fluorescence labeling systems for cancer diagnosis and treatment

Cancer Science.， 2022； 113(6)：1919-1929

DOI:10.1111/cas.15369

Hiroshi Tazawa, Kunitoshi Shigeyasu, Kazuhiro Noma, Shunsuke Kagawa, Fuminori Sakurai, Hiroyuki Mizuguchi, Hisataka Kobayashi, Takeshi Imamura, Toshiyoshi Fujiwara

英文原著 Aryl hydrocarbon receptor signals in epithelial cells govern the recruitment and location of Helios+ Tregs in the gut

Cell Reports.， 2022； 39(6)：110773

DOI:10.1016/j.celrep.2022.110773

Yusuke Yoshimatsu, Tomohisa Sujino, Kentaro Miyamoto, Yosuke Harada, Shun Tanemoto, Keiko Ono, Satoko Umeda, Kosuke Yoshida, Toshiaki Teratani, Takahiro Suzuki, Yohei Mikami, Nobuhiro Nakamoto, Nobuo Sasaki, Kaoru Takabayashi, Naoki Hosoe, Haruhiko Ogata, Kazuaki Sawada, Takeshi Imamura, Akihiko Yoshimura, Takanori Kanai,

英文原著 Differences in interaction lead to the formation of different types of insulin amyloid

scientific reports.， 2022； 12：8556

DOI:10.1038/s41598-022-12212-6

Wakako Mori, Ryosuke Kawakami, Yosuke Niko, Tomohiro Haruta, Takeshi Imamura, Kentaro Shiraki & Tamotsu Zako

英文原著 Computer-Aided Detection of Quantitative Signatures for Breast Fibroepithelial Tumors Using Label-Free Multi-Photon Imaging

Molecules.， 2022； 27(10)：3340

DOI:10.3390/molecules27103340

Kana Kobayashi-Taguchi, Takashi Saitou, Yoshiaki Kamei, Akari Murakami, Kanako Nishiyama, Reina Aoki, Erina Kusakabe, Haruna Noda, Michiko Yamashita, Riko Kitazawa, Takeshi Imamura and Yasutsugu Takada

英文原著 Cell–matrix interface regulates dormancy in human colon cancer stem cells.

Nature.， 2022； 608：784–794

DOI:10.1038/s41586-022-05043-y

Yuki Ohta, Masayuki Fujii, Sirirat Takahashi, Ai Takano, Kosaku Nanki, Mami Matano, Hikaru Hanyu, Megumu

英文原著 Identification of Quiescent LGR5+ Stem Cells in the Human Colon

Gastroenterology.， 2022； 163(5)：1391-1406.e24

DOI:10.1053/j.gastro.2022.07.081

Keiko Ishikawa, Shinya Sugimoto, Mayumi Oda, Masayuki Fujii, Sirirat Takahashi, Yuki Ohta, Ai Takano, Kazuhiro Ishimaru, Mami Matano, Kosuke Yoshida, Hikaru Hanyu, Kohta Toshimitsu, Kazuaki Sawada, Mariko Shimokawa, Megumu Saito, Kenta Kawasaki, Ryota Ishii, Koji Taniguchi, Takeshi Imamura, Takanori Kanai, Toshiro Sato,

英文原著 NIR-II-Excitable Dye-Loaded Nanoemulsions for Two-Photon Microscopy Imaging of Capillary Blood Vessels in the Entire Hippocampal CA1 Region of Living Mice

ACS Applied Materials & Interfaces.， 2022； 14(36)：40481–40490

DOI:10.1021/acsami.2c03299

Hitomi Matsuura, Ryosuke Kawakami, Maki Isoe, Masaharu Hoshihara, Yuya Minami, Kazuki Yatsuzuka, Teruko Tsuda, Masamoto Murakami, Yasutaka Suzuki, Jun Kawamata, Takeshi Imamura, Shingo Hadano, Shigeru Watanabe, and Yosuke Niko