To the Future with
PROTEO-SCIENCE

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ABOUT PROS

Proteins are the building blocks of life. The wheat cell-free protein synthesis method, pioneered here at PROS, enables the high-throughput, large scale synthesis of high quality proteins.

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PRiME

PRiME is a joint-use, collaborative research center focusing on interactome analysis set up by the Proteo-Science Center at Ehime University.
Collaborative research is the bedrock of our center, and we are continuously adapting our program to facilitate our ability to work together with researchers all over the world.

DEPARTMENTS

The Proteo-Science Center at Ehime University consists of various diverse research departments affiliated with 'Fundamental Technology Development‘ and 'Complex Bioscience Analysis’. We aim to promote protein-based life science research, and to use our expertise to inform the development of novel diagnostics and therapeutics for the improvement of human health.

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ACHIEVEMENTS

Original paper Biotin binder (BB) and BB-LucYY5: A sensitive and quantitative platform for biotin-labelled protein analysis

Biochemical and Biophysical Research Communications., 2025; 796:153125
DOI:10.1016/j.bbrc.2025.153125
Mana Hamada, Suzuno Hirano, Kohdai Yamada, Soh Tokunaga, Tatsuhiko Ozawa, Hiroyuki Takeda, Mayumi Tachibana, Motomi Torii, Akira Nozawa, Tatsuya Sawasaki

Original paper Evaluation of Malaria Parasite Transmission Competency Using a Nanozyme-Based Immunodiagnostic Targeting Female Gamete Antigen Release

ACS Nano., 2025; 19:36419−36434
DOI:10.1021/acsnano.5c10298
Tabasom Haghighi, Adrian Najer*, Marta Broto, Farah A. Dahalan, Alisje Churchyard, Sabrina Yahiya, Mufuliat T. Famodimu, Mark Tunnicliff, Aida Abdelwahed, Mayumi Tachibana, Tomoko Ishino, Yaw Aniweh, Gordon A. Awandare, Almahamoudou Mahamar, Leen N. Vanheer, Teun Bousema, Chris Drakeley, Alassane Dicko, William Stone, Jake Baum*, Molly M. Stevens*

Original paper Enhancing Global Science Education at Ehime University for the Next Generation

日本科学教育学会年会論文集., 2025; 49:629-632
DOI:10.14935/jssep.49.0_629
Aki KATO, Richard CULLETON, Ruth VERGIN

Original paper CDH11 contributes to bladder cancer progression via regulation of mitochondrial energy metabolism

Cancer Med.., 2025; 14(22):e71399
DOI:10.1002/cam4.71399
Arai O, Yanagihara Y, Arai H, Watanabe R, Miura N, Kikugawa T, Saika T, Imai Y.

Original paper Estrogen signaling in PDGFRα+ cells positively regulates cortical bone metabolism via IGFBP5 in female mice

JBMR Plus.., 2025; 1:ziaf178
DOI:10.1093/jbmrpl/ziaf178
Ikedo A, Aoki R, Sakai H, Saeki N, Yanagihara Y, Moody J, Kojima M, Kouno T, Ando Y, Hino K, Kinoshita T, Carninci P, Shin JW, Hon CC, Uezumi A, Kamei Y, Imai Y.