To the Future with
PROTEO-SCIENCE

イメージ：
イメージ：
イメージ：
イメージ：
イメージ：
プライムの情報はこちら

INFORMATION

VIEW MORE

ABOUT PROS

Proteins are the building blocks of life. The wheat cell-free protein synthesis method, pioneered here at PROS, enables the high-throughput, large scale synthesis of high quality proteins.

VIEW MORE
イメージ：
イメージ：
イメージ：
イメージ：
イメージ：

PRiME

PRiME is a joint-use, collaborative research center focusing on interactome analysis set up by the Proteo-Science Center at Ehime University.
Collaborative research is the bedrock of our center, and we are continuously adapting our program to facilitate our ability to work together with researchers all over the world.

VIEW MORE

DEPARTMENTS

The Proteo-Science Center at Ehime University consists of various diverse research departments affiliated with 'Fundamental Technology Development‘ and 'Complex Bioscience Analysis’. We aim to promote protein-based life science research, and to use our expertise to inform the development of novel diagnostics and therapeutics for the improvement of human health.

VIEW MORE
イメージ：研究部門

ACHIEVEMENTS

Original paper Machine learning-based insights into circulating autoantibody dynamics and treatment outcomes in patients with NSCLC receiving immune checkpoint inhibitors.

Front Immunol..， 2025； 16：1666030
DOI:10.3389/fimmu.2025.1666030.
Wei F, Takeda H, Azuma K, Nakahara Y, Igarashi Y, Murotani K, Saito H, Murakami S, Kondo T, Kouro T, Himuro H, Tsuji K, Komahashi M, Sawasaki T, Sasada T.

Original paper In-cell proximity target validation methods for heterobifunctional molecules with CRBN- or VHL-binder using AirID.

Commun Biol..， 2025； 8：1323
DOI:10.1038/s42003-025-08761-x.
Yamada K, Yamanaka S, Yamakoshi H, Kohyama A, Iwabuchi Y, Kosako H, Sawasaki T.

Original paper ZFP36L1 and L2 as novel antiviral factors for Crimean-Congo hemorrhagic fever virus via interaction with viral nucleoprotein.

J Biol Chem..， 2025； 301：110545
DOI:10.1016/j.jbc.2025.110545.
Hirano M, Nochi K, Matsugi M, Furukawa C, Takeda H, Sakurai Y, Kurosaki Y, Sawasaki T, Yasuda J, Takahashi H, Yoshii K.

Original paper Structural insights into CDF1 accumulation on the CONSTANS promoter via a plant-specific DNA-binding domain.

Nat Plants..， 2025； 11：836-848
DOI:10.1038/s41477-025-01946-6.
Furihata H, Zhu Z, Nishida K, Sakuraba Y, Tsuji A, Yamashita H, Nosaki S, Tachibana R, Yamagami A, Ikeda Y, Abe M, Sawasaki T, Nakano T, Yanagisawa S, Tanokura M, Miyakawa T.

Original paper Amino acid-dependent TSC2 dephosphorylation by lysosome-PP2A regulates mTORC1 signaling transduction.

Life Sci Alliance..， 2025； 8：e202503206
DOI:10.26508/lsa.202503206.
Nakamura T, Nada S, Matsumoto M, Loling Othman N, Kosako H, Ikeda K, Koshikawa N, Masumoto J, Sawasaki T, Takekawa M, Suzuki T, Okada M.
VIEW MORE