Achievements

Original paper Energetics in Photosystem II from Thermosynechococcus elongatus with a D1 protein encoded by either the psbA1 or psbA3 gene

Biochim. Biophys. Acta, (Bioenergetics).， 2010； 1797：1491-1499

DOI:10.1016

Sugirua, M., Kato, Y., Takahashi, R., Suzuki, H., Watanabe, T., Noguchi, T., Rappaprot, F. and Boussac, A.

Original paper Photoelectron generation by photosystem II core complexes tethered to gold surfaces

Chem. Sus. Chem..， 2010； 3：471-475

DOI:10.1002

Vittadello, M., Gorbunov, M.Y., Mastrogiovanni, D.T., Wielunski, L.S., Garfunkel E.L., Guerrero F., Kirilovsky D., Sugiura, M., Rutherford, A.W., Safari A., and Falkowski, P.G.

Original paper Hydrogen bond interactions of the pheophytin electron acceptor and its radical anion in photosystem II as revealed by Fourier transform infrared difference spectroscopy.

Biochemistry.， 2010； 49：493-501

DOI:10.1021

Shibuya, Y, Takahashi, R., Okubo, T., Suzuki, H., Sugiura, M., and Noguchi, T.

Original paper Recent advances in the epidermal growth factor receptor/ligand system biology on skin homeostasis and keratinocyte stem cell regulation.

J Dermatol Sci..， 2013； 72(2)：81-86

DOI:10.1016/j.jdermsci.2013.05.009

Nanba D, Toki F, Barrandon Y, Higashiyama S.

Original paper Heparin-binding EGF-like growth factor enhances the activity of invasion and metastasis in thyroid cancer cells.

Oncol Rep..， 2013； 30(4)：1593-1600

DOI:10.3892/or.2013.2659

Ota I, Higashiyama S, Masui T, Yane K, Hosoi H, Matsuura N.

Original paper Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice.

Biochem Biophys Res Commun..， 2013； 437(2)：185-191

DOI:10.1016/j.bbrc.2013.05.097

Takemura T, Yoshida Y, Kiso S, Kizu T, Furuta K, Ezaki H, Hamano M, Egawa M, Chatani N, Kamada Y, Imai Y, Higashiyama S, Iwamoto R, Mekada E, Takehara T.

Original paper Annexin A2 regulates a disintegrin and metalloproteinase 17-mediated ectodomain shedding of pro-tumor necrosis factor-α in monocytes and colon epithelial cells.

Inflamm Bowel Dis..， 2013； 19(7)：1365-1373

DOI:10.1097/MIB.0b013e318281f43a

Tsukamoto H, Tanida S, Ozeki K, Ebi M, Mizoshita T, Shimura T, Mori Y, Kataoka H, Kamiya T, Fukuda S, Higashiyama S, Joh T.

Original paper Spatiotemporal visualization of proHB-EGF ectodomain shedding in living cells.

J Biochem..， 2013； 154(1)：67-76

DOI:10.1093/jb/mvt030

Inoue H, Sakaue T, Ozawa T, Higashiyama S.

Original paper Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia.

J Cell Biol..， 2013； 201(2)：279-292

DOI:10.1083/jcb.201209151

Díaz B, Yuen A, Iizuka S, Higashiyama S, Courtneidge SA.

Original paper Cisplatin influences acquisition of resistance to molecular-targeted agents through epithelial-mesenchymal transition-like changes.

Cancer Sci..， 2013； 104(7)：904-911

DOI:10.1111/cas.12171

Kurokawa M, Ise N, Omi K, Goishi K, Higashiyama S.

Original paper Doxycycline-dependent inducible and reversible RNA interference mediated by a single lentivirus vector.

Biosci Biotechnol Biochem..， 2013； 77(4)：776-781

DOI:10.1271/bbb.120917

Matsushita N, Matsushita S, Hirakawa S, Higashiyama S.

Original paper Actin filament dynamics impacts keratinocyte stem cell maintenance.

EMBO Mol Med..， 2013； 5(4)：640-653

DOI:10.1002/emmm.201201839

Nanba D, Toki F, Matsushita N, Matsushita S, Higashiyama S, Barrandon Y.

Original paper Protein kinase D2 and heat shock protein 90 beta are required for BCL6-associated zinc finger protein mRNA stabilization induced by vascular endothelial growth factor-A.

Angiogenesis..， 2013； 16：675-688

DOI:10.1007/s10456-013-9345-x

Miwa D, Sakaue T, Inoue H, Takemori N, Kurokawa M, Fukuda S, Omi K, Goishi K, Higashiyama S.

Original paper ErbB2 dephosphorylation and anti-proliferative effects of neuregulin-1 in ErbB2-overexpressing cells; re-evaluation of their low-affinity interaction.

Sci Rep..， 2013； 3：1402

DOI:10.1038/srep01402

Wang R, Iwakura Y, Araki K, Keino-Masu K, Masu M, Wang XY, Takei N, Higashiyama S, Nawa H.

Original paper Telmisartan inhibits cell proliferation by blocking nuclear translocation of ProHB-EGF C-terminal fragment in colon cancer cells.

PLoS One..， 2013； 8(2)：e56770

DOI:10.1371/journal.pone.0056770

Ozeki K, Tanida S, Morimoto C, Inoue Y, Mizoshita T, Tsukamoto H, Shimura T, Kataoka H, Kamiya T, Nishiwaki E, Ishiguro H, Higashiyama S, Joh T.

Original paper Human antigen R-mediated mRNA stabilization is required for ultraviolet B-induced autoinduction of amphiregulin in keratinocytes.

J Biol Chem..， 2013； 288(15)：10338-10348

DOI:10.1074/jbc.M112.417527

Nakayama H, Fukuda S, Matsushita N, Nishida-Fukuda H, Inoue H, Shirakata Y, Hashimoto K, Higashiyama S.

Original paper Conditional knockout of heparin-binding epidermal growth factor-like growth factor in the liver accelerates carbon tetrachloride-induced liver injury in mice.

Hepatol Res..， 2013； 43(4)：384-393

DOI:10.1111/j.1872-034X.2012.01074.x

Takemura T, Yoshida Y, Kiso S, Saji Y, Ezaki H, Hamano M, Kizu T, Egawa M, Chatani N, Furuta K, Kamada Y, Iwamoto R, Mekada E, Higashiyama S, Hayashi N, Takehara T.

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