Achievements

Original paper Dysregulated mature IL-1β production in familial Mediterranean fever

Rheumatology (Oxford)..， 2015； 54：660-665

DOI:10.1093/rheumatology/keu359

Migita K, Izumi Y, Fujikawa K, Agematsu K, Masumoto J, Jiuchi Y, Kozuru H, Nonaka F, Shimizu T, Nakamura T, Iwanaga N, Furukawa H, Yasunami M, Kawakami A, Eguchi K

Original paper A cell-free enzymatic activity assay for the evaluation of HIV-1 drug resistance to protease inhibitors.

Front Microbiol..， 2015； 6：1220

DOI:10.3389/fmicb.2015.01220

Matsunaga S, Masaoka T, Sawasaki T, Morishita R, Iwatani Y, Tatsumi M, Endo Y, Yamamoto N, Sugiura W, Ryo A.

Original paper Wheat germ-based protein libraries for the functional characterisation of the Arabidopsis E2 ubiquitin conjugating enzymes and the RING-type E3 ubiquitin ligase enzymes.

BMC Plant Biol..， 2015； 15：275

DOI:10.1186/s12870-015-0660-9

Ramadan A, Nemoto K, Seki M, Shinozaki K, Takeda H, Takahashi H, Sawasaki T.

Original paper Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD.

Biomark Insights.， 2015； 10：63-73

DOI:10.4137/BMI.S28209

Furukawa H, Oka S, Shimada K, Masuo K, Nakajima F, Funano S, Tanaka Y, Komiya A, Fukui N, Sawasaki T, Tadokoro K, Nose M, Tsuchiya N, Tohma S.

Original paper Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly.

Proc Natl Acad Sci U S A..， 2015； 112：E4465-4474

DOI:10.1073/pnas.1421182112

Ohnishi T, Yanazawa M, Sasahara T, Kitamura Y, Hiroaki H, Fukazawa Y, Kii I, Nishiyama T, Kakita A, Takeda H, Takeuchi A, Arai Y, Ito A, Komura H, Hirao H, Satomura K, Inoue M, Muramatsu SI, Matsui K, Tada M, Sato M, Saijo E, Shigemitsu Y, Sakai S, Umetsu Y, Goda N, Takino N, Takahashi H, Hagiwara M, Sawasaki T, Iwasaki G, Nakamura Y, Nabeshima YI, Teplow DB, Hoshi M.

Original paper Functional Characterization of the Receiver Domain for Phosphorelay Control in Hybrid Sensor Kinases.

PLoS One.， 2015； 10：e0132598

DOI:10.1371/journal.pone.0132598

Kinoshita-Kikuta E, Kinoshita E, Eguchi Y, Yanagihara S, Edahiro K, Inoue Y, Taniguchi M, Yoshida M, Yamamoto K, Takahashi H, Sawasaki T, Utsumi R, Koike T.

Original paper Claudin-1 binder enhances epidermal permeability in a human keratinocyte model.

J Pharmacol Exp Ther..， 2015； 354：440-447

DOI:10.1124/jpet.115.225391

Nakajia M, Nagase S, Iida M, Takeda S, Yamashita M, Watari A, Shirasago Y, Fukasawa M, Takeda H, Sawasaki T, Yagi K, Kondoh M.

Original paper Novel Autoantigens Associated with Lupus Nephritis.

PLoS One.， 2015； 10：e0126564

DOI:10.1371/journal.pone.0126564

Onishi S, Adnan E, Ishizaki J, Miyazaki T, Tanaka Y, Matsumoto T, Suemori K, Shudou M, Okura T, Takeda H, Sawasaki T, Yasukawa M, Hasegawa H.

Original paper Production of monoclonal antibodies against GPCR using cell-free synthesized GPCR antigen and biotinylated liposome-based interaction assay.

Sci Rep..， 2015； 5：11333

DOI:10.1038/srep11333

Takeda H, Ogasawara T, Ozawa T, Muraguchi A, Jih PJ, Morishita R, Uchigashima M, Watanabe M, Fujimoto T, Iwasaki T, Endo Y, Sawasaki T.

Original paper Members of the Plant CRK-superfamily are Capable of trans-/auto-Phosphorylation of Tyrosine Residues.

J Biol Chem..， 2015； 290：16665-16677

DOI:10.1074/jbc.M114.617274

Nemoto K, Takemori N, Seki M, Shinozaki K, Sawasaki T.

Original paper High-throughput synthesis of stable isotope-labeled transmembrane proteins for targeted transmembrane proteomics using a wheat germ cell-free protein synthesis system.

Mol Biosyst..， 2015； 11：361-365

DOI:10.1039/c4mb00556b

Takemori N, Takemori A, Matsuoka K, Morishita R, Matsushita N, Aoshima M, Takeda H, Sawasaki T, Endo Y, Higashiyama S.

Original paper MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response.

Cell Rep..， 2015； 10：1722-1734

DOI:10.1016/j.celrep.2015.02.030

James SJ, Jiao H, Teh HY, Takahashi H, Png CW, Phoon MC, Suzuki Y, Sawasaki T, Xiao H, Chow VT, Yamamoto N, Reynolds JM, Flavell RA, Dong C, Zhang Y.

Original paper AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity.

FASEB J..， 2014； 28(7)：3211-24

DOI:10.1096/fj.14-250449

Lantier L, Fentz J, Mounier R,Leclerc J, Treebak JT, Pehmøller C, Sanz N, Sakakibara I, Saint-Amand E,Rimbaud S, Maire P, Marette A, Ventura-Clapier R,Ferry A, Wojtaszewski JF, Foretz M, Viollet B.

Original paper Fatostatin, an SREBP inhibitor, prevented RANKL-induced bone loss by suppression of osteoclast differentiation.

BBA-Molecular Basis of Disease..， 2015； 1852(11)：2432-41

DOI:10.1016/j.bbadis.2015.08.018

Inoue K and Imai Y.

Original paper ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease.

Am J Physiol Renal Physiol..， 2014； 307(5)：F551-9

DOI:10.1152/ajprenal.00218.2014

Beck Gooz M, Maldonado EN, Dang Y, Amria MY, Higashiyama S, Abboud HE, Lemasters JJ, Bell PD

Original paper Pathophysiology of lung injury induced by common bile duct ligation in mice.

PLoS One..， 2014； 9(4)：e94550

DOI:10.1371/journal.pone.0094550

Shikata F, Sakaue T, Nakashiro K, Okazaki M, Kurata M, Okamura T, Okura M, Ryugo M, Nakamura Y, Yasugi T, Higashiyama S, Izutani H

Original paper Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage.

Proc Natl Acad Sci U S A..， 2014； 111(2)：717-22

DOI:10.1073/pnas.1313675111

Taira N, Yamaguchi T, Kimura J, Lu ZG, Fukuda S, Higashiyama S, Ono M, Yoshida K

Original paper Genome-wide comprehensive analysis reveals critical cooperation between Smad and c-Fos in RANKL-induced osteoclastogenesis.

J Bone Miner Res..， 2015； 30(5)：869-77

DOI:10.1002/jbmr.2418

Omata Y, Yasui T, Hirose J, Izawa N, Imai Y, Matsumoto T, Masuda H, Tokuyama N, Nakamura S, Tsutsumi S, Yasuda H, Okamoto K, Takayanagi H, Hikita A, Imamura T, Matsuo K, Saito T, Kadono Y, Aburatani H, Tanaka S.

Original paper Biofunction-assisted aptasensors based on ligand-dependent 3’ processing of a suppressor tRNA in a wheat germ extract

Org. Biomol. Chem..， 2015； 13(24)：6681-6685

DOI:10.1039/C5OB00794A

Ogawa A, Tabuchi J

Original paper Fate, origin and roles of cells within free bone grafts.

J Orthop Sci.， 2015； 20(2)：390-6

DOI:10.1007/s00776-014-0673-5

Yano K, Yasuda H, Takaoka K, Takahashi M, Nakamura H, Imai Y, Wakitani S.

ACHIEVEMENTS

SEARCH ACHIEVEMENTS