Achievements

Original paper ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease.

Am J Physiol Renal Physiol..， 2014； 307(5)：F551-9

DOI:10.1152/ajprenal.00218.2014

Beck Gooz M, Maldonado EN, Dang Y, Amria MY, Higashiyama S, Abboud HE, Lemasters JJ, Bell PD

Original paper Pathophysiology of lung injury induced by common bile duct ligation in mice.

PLoS One..， 2014； 9(4)：e94550

DOI:10.1371/journal.pone.0094550

Shikata F, Sakaue T, Nakashiro K, Okazaki M, Kurata M, Okamura T, Okura M, Ryugo M, Nakamura Y, Yasugi T, Higashiyama S, Izutani H

Original paper Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage.

Proc Natl Acad Sci U S A..， 2014； 111(2)：717-22

DOI:10.1073/pnas.1313675111

Taira N, Yamaguchi T, Kimura J, Lu ZG, Fukuda S, Higashiyama S, Ono M, Yoshida K

Original paper Genome-wide comprehensive analysis reveals critical cooperation between Smad and c-Fos in RANKL-induced osteoclastogenesis.

J Bone Miner Res..， 2015； 30(5)：869-77

DOI:10.1002/jbmr.2418

Omata Y, Yasui T, Hirose J, Izawa N, Imai Y, Matsumoto T, Masuda H, Tokuyama N, Nakamura S, Tsutsumi S, Yasuda H, Okamoto K, Takayanagi H, Hikita A, Imamura T, Matsuo K, Saito T, Kadono Y, Aburatani H, Tanaka S.

Original paper Biofunction-assisted aptasensors based on ligand-dependent 3’ processing of a suppressor tRNA in a wheat germ extract

Org. Biomol. Chem..， 2015； 13(24)：6681-6685

DOI:10.1039/C5OB00794A

Ogawa A, Tabuchi J

Original paper Fate, origin and roles of cells within free bone grafts.

J Orthop Sci.， 2015； 20(2)：390-6

DOI:10.1007/s00776-014-0673-5

Yano K, Yasuda H, Takaoka K, Takahashi M, Nakamura H, Imai Y, Wakitani S.

Original paper Electron transfer pathways from the S2-states to the S3-states either after a Ca2+/Sr2+ or a Cl-/I- exchange in Photosystem II from Thermosynechococcus elongatus

Biochim. Biophys. Acta (Bioenergetics).， 2015； 1847：576-585

DOI:10.1016/j.bbabio.2014.11.009

Boussac, A., Rutherford, A.W, and Sugiura, M.

Original paper Assembly of oxygen-evolving Photosystem II efficiently occurs with the apo-Cytb559 but the holo-Cytb559 accelerates the recovery of a functional enzyme upon photoinhibition.

Biochim Biophys Acta.， 2015； 1847：276-85

DOI:10.1016/j.bbabio.2014.11.009

Sugiura M, Nakamura M, Koyama K, Boussac A.

Original paper Engineering of Ribosomal Shunt-Modulating Eukaryotic ON Riboswitches by Using a Cell-Free Translation System

Methods Enzymol..， 2015； 550：109-128

DOI:10.1016/bs.mie.2014.10.033

Ogawa A

Original paper Pctaire1/Cdk16 promotes skeletal myogenesis by inducing myoblast migration and fusion.

FEBS Lett.， 2014； 588(17)：412907

DOI:10.1016/j.febslet.2014.05.060

Shimizu K, Uematsu A, Imai Y, Sawasaki T

Original paper Cisplatin resistance by induction of aldo-keto reductase family 1 member C2 in human bladder cancer cells.

Oncol Lett.， 2014； 7(3)：674-678

DOI:10.3892/ol.2013.1768

Shirato A, Kikugawa T, Miura N, Tanji N, Takemori N, Higashiyama S, Yokoyama M.

Original paper Enzymatic protein digestion using a dissolvable polyacrylamide gel and its application to mass spectrometry-based proteomics.

J Chromatogr B Analyt Technol Biomed Life Sci.， 2014； 967：36-40

DOI:10.1016/j.jchromb.2014.07.006

Takemori N, Takemori A, Ishizaki J, Hasegawa H.

Original paper Wide field intravital imaging by two-photon-excitation digital-scanned light-sheet microscopy (2p-DSLM) with a high-pulse energy laser.

Biomed Opt Express.， 2014； 5：3311-25

DOI:10.1364/BOE.5.003311

Maruyama A, Oshima Y, Kajiura-Kobayashi H, Nonaka S, Imamura T, Naruse K.

Original paper Ultrasensitive imaging of Ca2+ dynamics in pancreatic acinar cells of yellow ameleon-nano transgenic mice

Int J Mol Sci.， 2014； 15：19971-86

DOI:10.3390/ijms151119971

Oshima Y, Imamura T, Shintani A, Kajiura-Kobayashi H, Hibi T, Nagai T, Nonaka S, Nemoto T.

Original paper Serum amyloid A induces NLRP-3-mediated IL-1β secretion in neutrophils

PLoS One..， 2014； 9：e96703

DOI:10.1371/journal.pone.0096703

Migita K, Izumi Y, Jiuchi Y, Kozuru H, Kawahara C, Nakamura M, Nakamura T, Agematsu K, Masumoto J, Yasunami M, Kawakami A, Eguchi K

Original paper Familial Mediterranean fever: genotype-phenotype correlations in Japanese patients

Medicine (Baltimore)..， 2014； 93：158-164

DOI:10.1097/MD.0000000000000029

Migita K, Agematsu K, Yazaki M, Nonaka F, Nakamura A, Toma T, Kishida D, Uehara R, Nakamura Y, Jiuchi Y, Masumoto J, Furukawa H, Ida H, Terai C, Nakashima Y, Kawakami A, Nakamura T, Eguchi K, Yasunami M, Yachie A.

Original paper Microvasculature of carotid atheromatous plaques: hemorrhagic plaques have dense microvessels with fenestrations to the arterial lumen

J Stroke Cerebrovasc Dis..， 2014； 23：1440-1446

DOI:10.1016/j.jstrokecerebrovasdis.2013.12.003

Kurata M, Nose M, Shimazu Y, Aoba T, Kohada Y, Yorioka S, Suehiro S, Fukuoka E, Matsumoto S, Watanabe H, Kumon Y, Okura T, Higaki J, Masumoto J.

Original paper Defect of suppression of inflammasome-independent interleukin-8 secretion from SW982 synovial sarcoma cells by familial Mediterranean fever-derived pyrin mutations

Mol Biol Rep.， 2014； 41：545-553

DOI:10.1007/s11033-013-2890-y

Sugiyama R, Agematsu K, Migita K, Nakayama J, Mokuda S, Ogura F, Haraikawa K, Okumura C, Suehiro S, Morikawa S, Ito Y, Masumoto J.

Original paper Tocilizumab improved clinical symptoms of a patient with systemic tophaceous gout who had symmetric polyarthritis and fever: An alternative treatment by blockade of interleukin-6 signaling

SAGE Open Medical Case Reports.， 2014； 2：2050313X13519774

DOI:10.1177/2050313X13519774

Mokuda S, Kanno M, Takasugi K, Okumura C, Ito Y, Masumoto J

Original paper SSP3 is a novel Plasmodium yoelii sporozoite surface protein with a role in gliding motility

Infect Immun.， 2014； 82：4643-4653

DOI:10.1128/IAI.01800-14

Anke Harupa, Brandon K. Sack, Viswanathan Lakshmanan, Nadia Arang, Alyse N. Douglass, Brian G. Oliver, Andrew B. Stuart, D. Noah Sather, Scott E. Lindner, Kevin Hybiske, Motomi Torii, Stefan H. I. Kappe

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