Achievements

Original paper Evidence that Entamoeba hystlytica mitochondrial carrier family links mitosomal and cytosolic pathways through exchange of PAPS and ATP.

Eukaryot. Cell.， 2015； 14：1144-1150

DOI:10.1128/EC.00130-15

Fumika Mi-ichi, Akira Nozawa, Hiroki Yoshida, Yuzuru Tozawa, and Tomoyoshi Nozaki

Original paper Reconstituted AIM2 inflammasome in cell-free system.

J Immunol Methods.， 2015； 426：76-81

DOI:10.1016/j.jim.2015.08.004

Kaneko N, Ito Y, Iwasaki T, Takeda H, Sawasaki T, Migita K, Agematsu K, Kawakami A, Morikawa S, Mokuda S, Kurata M, Masumoto J.

Original paper The proto-oncogene survivin splice variant 2B is induced by PDGF and leads to cell proliferation in rheumatoid arthritis fibroblast-like synoviocytes.

Sci Rep..， 2015； 5：9795

DOI:10.1371/journal.pone.0125938

Mokuda S, Miyazaki T, Ito Y, Yamasaki S, Inoue H, Guo Y, Kong WS, Kanno M, Takasugi K, Sugiyama E, Masumoto J.

Original paper Identification of Disease-Promoting HLA Class I and Protective Class II Modifiers in Japanese Patients with Familial Mediterranean Fever.

PLoS One.， 2015； 10：e0125938

DOI:10.1371/journal.pone.0125938

asunami M, Nakamura H, Agematsu K, Nakamura A, Yazaki M, Kishida D, Yachie A, Toma T, Masumoto J, Ida H, Koga T, Kawakami A, Eguchi K, Furukawa H, Nakamura T, Nakamura M, Migita K.

Original paper Development of tumor-specific caffeine-potentiated chemotherapy using a novel drug delivery system with Span 80 nano-vesicles

Oncol Rep..， 2015； 33：1593-1598

DOI:10.3892/or.2015.3761

Nakata H, Miyazaki T, Iwasaki T, Nakamura A, Kidani T, Sakayama K, Masumoto J, Miura H

Original paper Epstein-Barr virus-related MTX-LPD in rheumatoid arthritis patients exhibits a viral pattern of the CD64 and CD35 expression on neutrophils: Three case reports

Mod Rheumatol..， 2015； 25：166-168

DOI:10.3109/14397595.2013.875641

Mokuda S, Miyazaki T, Saeki Y, Masumoto J, Kanno M, Takasugi K.

Original paper Dysregulated mature IL-1β production in familial Mediterranean fever

Rheumatology (Oxford)..， 2015； 54：660-665

DOI:10.1093/rheumatology/keu359

Migita K, Izumi Y, Fujikawa K, Agematsu K, Masumoto J, Jiuchi Y, Kozuru H, Nonaka F, Shimizu T, Nakamura T, Iwanaga N, Furukawa H, Yasunami M, Kawakami A, Eguchi K

Original paper A cell-free enzymatic activity assay for the evaluation of HIV-1 drug resistance to protease inhibitors.

Front Microbiol..， 2015； 6：1220

DOI:10.3389/fmicb.2015.01220

Matsunaga S, Masaoka T, Sawasaki T, Morishita R, Iwatani Y, Tatsumi M, Endo Y, Yamamoto N, Sugiura W, Ryo A.

Original paper Wheat germ-based protein libraries for the functional characterisation of the Arabidopsis E2 ubiquitin conjugating enzymes and the RING-type E3 ubiquitin ligase enzymes.

BMC Plant Biol..， 2015； 15：275

DOI:10.1186/s12870-015-0660-9

Ramadan A, Nemoto K, Seki M, Shinozaki K, Takeda H, Takahashi H, Sawasaki T.

Original paper Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD.

Biomark Insights.， 2015； 10：63-73

DOI:10.4137/BMI.S28209

Furukawa H, Oka S, Shimada K, Masuo K, Nakajima F, Funano S, Tanaka Y, Komiya A, Fukui N, Sawasaki T, Tadokoro K, Nose M, Tsuchiya N, Tohma S.

Original paper Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly.

Proc Natl Acad Sci U S A..， 2015； 112：E4465-4474

DOI:10.1073/pnas.1421182112

Ohnishi T, Yanazawa M, Sasahara T, Kitamura Y, Hiroaki H, Fukazawa Y, Kii I, Nishiyama T, Kakita A, Takeda H, Takeuchi A, Arai Y, Ito A, Komura H, Hirao H, Satomura K, Inoue M, Muramatsu SI, Matsui K, Tada M, Sato M, Saijo E, Shigemitsu Y, Sakai S, Umetsu Y, Goda N, Takino N, Takahashi H, Hagiwara M, Sawasaki T, Iwasaki G, Nakamura Y, Nabeshima YI, Teplow DB, Hoshi M.

Original paper Functional Characterization of the Receiver Domain for Phosphorelay Control in Hybrid Sensor Kinases.

PLoS One.， 2015； 10：e0132598

DOI:10.1371/journal.pone.0132598

Kinoshita-Kikuta E, Kinoshita E, Eguchi Y, Yanagihara S, Edahiro K, Inoue Y, Taniguchi M, Yoshida M, Yamamoto K, Takahashi H, Sawasaki T, Utsumi R, Koike T.

Original paper Claudin-1 binder enhances epidermal permeability in a human keratinocyte model.

J Pharmacol Exp Ther..， 2015； 354：440-447

DOI:10.1124/jpet.115.225391

Nakajia M, Nagase S, Iida M, Takeda S, Yamashita M, Watari A, Shirasago Y, Fukasawa M, Takeda H, Sawasaki T, Yagi K, Kondoh M.

Original paper Novel Autoantigens Associated with Lupus Nephritis.

PLoS One.， 2015； 10：e0126564

DOI:10.1371/journal.pone.0126564

Onishi S, Adnan E, Ishizaki J, Miyazaki T, Tanaka Y, Matsumoto T, Suemori K, Shudou M, Okura T, Takeda H, Sawasaki T, Yasukawa M, Hasegawa H.

Original paper Production of monoclonal antibodies against GPCR using cell-free synthesized GPCR antigen and biotinylated liposome-based interaction assay.

Sci Rep..， 2015； 5：11333

DOI:10.1038/srep11333

Takeda H, Ogasawara T, Ozawa T, Muraguchi A, Jih PJ, Morishita R, Uchigashima M, Watanabe M, Fujimoto T, Iwasaki T, Endo Y, Sawasaki T.

Original paper Members of the Plant CRK-superfamily are Capable of trans-/auto-Phosphorylation of Tyrosine Residues.

J Biol Chem..， 2015； 290：16665-16677

DOI:10.1074/jbc.M114.617274

Nemoto K, Takemori N, Seki M, Shinozaki K, Sawasaki T.

Original paper High-throughput synthesis of stable isotope-labeled transmembrane proteins for targeted transmembrane proteomics using a wheat germ cell-free protein synthesis system.

Mol Biosyst..， 2015； 11：361-365

DOI:10.1039/c4mb00556b

Takemori N, Takemori A, Matsuoka K, Morishita R, Matsushita N, Aoshima M, Takeda H, Sawasaki T, Endo Y, Higashiyama S.

Original paper MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response.

Cell Rep..， 2015； 10：1722-1734

DOI:10.1016/j.celrep.2015.02.030

James SJ, Jiao H, Teh HY, Takahashi H, Png CW, Phoon MC, Suzuki Y, Sawasaki T, Xiao H, Chow VT, Yamamoto N, Reynolds JM, Flavell RA, Dong C, Zhang Y.

Original paper AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity.

FASEB J..， 2014； 28(7)：3211-24

DOI:10.1096/fj.14-250449

Lantier L, Fentz J, Mounier R,Leclerc J, Treebak JT, Pehmøller C, Sanz N, Sakakibara I, Saint-Amand E,Rimbaud S, Maire P, Marette A, Ventura-Clapier R,Ferry A, Wojtaszewski JF, Foretz M, Viollet B.

Original paper Fatostatin, an SREBP inhibitor, prevented RANKL-induced bone loss by suppression of osteoclast differentiation.

BBA-Molecular Basis of Disease..， 2015； 1852(11)：2432-41

DOI:10.1016/j.bbadis.2015.08.018

Inoue K and Imai Y.

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