To the Future with
PROTEO-SCIENCE

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プライムの情報はこちら

INFORMATION

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ABOUT PROS

Proteins are the building blocks of life. The wheat cell-free protein synthesis method, pioneered here at PROS, enables the high-throughput, large scale synthesis of high quality proteins.

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PRiME

PRiME is a joint-use, collaborative research center focusing on interactome analysis set up by the Proteo-Science Center at Ehime University.
Collaborative research is the bedrock of our center, and we are continuously adapting our program to facilitate our ability to work together with researchers all over the world.

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DEPARTMENTS

The Proteo-Science Center at Ehime University consists of various diverse research departments affiliated with 'Fundamental Technology Development‘ and 'Complex Bioscience Analysis’. We aim to promote protein-based life science research, and to use our expertise to inform the development of novel diagnostics and therapeutics for the improvement of human health.

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イメージ：研究部門

ACHIEVEMENTS

Original paper Claudin 5-binding small molecule transiently opens the blood-brain barrier and safely enhances brain drug delivery

J Control Release.， 2025； 388：114314
DOI:10.1016/j.jconrel.2025.114314
Saito Inoue, Keisuke Shirakura, Atsuya Shirono, Jumpei Taguchi, Yoshiki Ikeda, Satomi Tomita, Risa Funatsu, Kosuke Muraoka, Yosuke Hashimoto, Keisuke Tachibana, Nobumasa Hino, Takefumi Doi, Yui Ikemi, Kazuto Nunomura, Bangzhong Lin, Shinsaku Nakagawa, Kazutake Tsujikawa, Shota Tanaka, Masanori Obana, Yasushi Fujio, Takamitsu Hosoya, Hiroyuki Takeda, Masuo Kondoh, Yoshiaki Okada

Original paper (日本語) Size-selective permeation-enhancing modulation of the tight junction by receptor-binding domains of Clostridium perfringens enterotoxin and Clostridium perfringens iota-toxin

Tissue Barriers.， 2025； 13：2459963
DOI:10.1080/21688370.2025.2459963
Size-selective permeation-enhancing modulation of the tight junction by receptor-binding domains of Clostridium perfringens enterotoxin and Clostridium perfringens iota-toxin

Original paper Structural basis of the hepatitis B virus X protein in complex with DDB1

Proc Natl Acad Sci U S A.， 2025； 122：e2421325122
DOI:10.1073/pnas.2421325122
Hiroki Tanaka, Joao Diogo Dias, Basile Jay, Shunsuke Kita, Mina Sasaki, Hiroyuki Takeda, Naoki Kishimoto, Shunsuke Sasaki, Shogo Misumi 5, Masashi Mizokami, Christine Neuveut, Takashi Sumikama, Mikihiro Shibata, Katsumi Maenaka, Shinichi Machida

Original paper Caspase-mediated cleavage of a scaffold protein, MPRIP, yields a truncated form that is involved in repetitive bleb formation

FEBS Journal.， 2025； 292：2287-2305
DOI:10.1111/febs.17422
Kazuhiro Sakamaki, Naohisa Sakamoto, Yuki Tsujimura, Takahiro Iwasaki, Takuma Kawamura, Jun Nakabayashi, Rhea S. D'Souza, Arooma Jannat, Ken-ichiro Takeshima, Hiroyuki Takeda, Koji Koyamada, Hideo Yokota

Original paper Machine learning-based insights into circulating autoantibody dynamics and treatment outcomes in patients with NSCLC receiving immune checkpoint inhibitors.

Front Immunol..， 2025； 16：1666030
DOI:10.3389/fimmu.2025.1666030.
Wei F, Takeda H, Azuma K, Nakahara Y, Igarashi Y, Murotani K, Saito H, Murakami S, Kondo T, Kouro T, Himuro H, Tsuji K, Komahashi M, Sawasaki T, Sasada T.
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