ACHIEVEMENTS

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英文原著 Dysregulated mature IL-1β production in familial Mediterranean fever

Rheumatology (Oxford).., 2015; 54:660-665
DOI:10.1093/rheumatology/keu359
Migita K, Izumi Y, Fujikawa K, Agematsu K, Masumoto J, Jiuchi Y, Kozuru H, Nonaka F, Shimizu T, Nakamura T, Iwanaga N, Furukawa H, Yasunami M, Kawakami A, Eguchi K

英文原著 A cell-free enzymatic activity assay for the evaluation of HIV-1 drug resistance to protease inhibitors.

Front Microbiol.., 2015; 6:1220
DOI:10.3389/fmicb.2015.01220
Matsunaga S, Masaoka T, Sawasaki T, Morishita R, Iwatani Y, Tatsumi M, Endo Y, Yamamoto N, Sugiura W, Ryo A.

英文原著 Wheat germ-based protein libraries for the functional characterisation of the Arabidopsis E2 ubiquitin conjugating enzymes and the RING-type E3 ubiquitin ligase enzymes.

BMC Plant Biol.., 2015; 15:275
DOI:10.1186/s12870-015-0660-9
Ramadan A, Nemoto K, Seki M, Shinozaki K, Takeda H, Takahashi H, Sawasaki T.

英文原著 Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD.

Biomark Insights., 2015; 10:63-73
DOI:10.4137/BMI.S28209
Furukawa H, Oka S, Shimada K, Masuo K, Nakajima F, Funano S, Tanaka Y, Komiya A, Fukui N, Sawasaki T, Tadokoro K, Nose M, Tsuchiya N, Tohma S.

英文原著 Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly.

Proc Natl Acad Sci U S A.., 2015; 112:E4465-4474
DOI:10.1073/pnas.1421182112
Ohnishi T, Yanazawa M, Sasahara T, Kitamura Y, Hiroaki H, Fukazawa Y, Kii I, Nishiyama T, Kakita A, Takeda H, Takeuchi A, Arai Y, Ito A, Komura H, Hirao H, Satomura K, Inoue M, Muramatsu SI, Matsui K, Tada M, Sato M, Saijo E, Shigemitsu Y, Sakai S, Umetsu Y, Goda N, Takino N, Takahashi H, Hagiwara M, Sawasaki T, Iwasaki G, Nakamura Y, Nabeshima YI, Teplow DB, Hoshi M.

英文原著 Functional Characterization of the Receiver Domain for Phosphorelay Control in Hybrid Sensor Kinases.

PLoS One., 2015; 10:e0132598
DOI:10.1371/journal.pone.0132598
Kinoshita-Kikuta E, Kinoshita E, Eguchi Y, Yanagihara S, Edahiro K, Inoue Y, Taniguchi M, Yoshida M, Yamamoto K, Takahashi H, Sawasaki T, Utsumi R, Koike T.

英文原著 Claudin-1 binder enhances epidermal permeability in a human keratinocyte model.

J Pharmacol Exp Ther.., 2015; 354:440-447
DOI:10.1124/jpet.115.225391
Nakajia M, Nagase S, Iida M, Takeda S, Yamashita M, Watari A, Shirasago Y, Fukasawa M, Takeda H, Sawasaki T, Yagi K, Kondoh M.

英文原著 Novel Autoantigens Associated with Lupus Nephritis.

PLoS One., 2015; 10:e0126564
DOI:10.1371/journal.pone.0126564
Onishi S, Adnan E, Ishizaki J, Miyazaki T, Tanaka Y, Matsumoto T, Suemori K, Shudou M, Okura T, Takeda H, Sawasaki T, Yasukawa M, Hasegawa H.

英文原著 Production of monoclonal antibodies against GPCR using cell-free synthesized GPCR antigen and biotinylated liposome-based interaction assay.

Sci Rep.., 2015; 5:11333
DOI:10.1038/srep11333
Takeda H, Ogasawara T, Ozawa T, Muraguchi A, Jih PJ, Morishita R, Uchigashima M, Watanabe M, Fujimoto T, Iwasaki T, Endo Y, Sawasaki T.

英文原著 Members of the Plant CRK-superfamily are Capable of trans-/auto-Phosphorylation of Tyrosine Residues.

J Biol Chem.., 2015; 290:16665-16677
DOI:10.1074/jbc.M114.617274
Nemoto K, Takemori N, Seki M, Shinozaki K, Sawasaki T.

英文原著 High-throughput synthesis of stable isotope-labeled transmembrane proteins for targeted transmembrane proteomics using a wheat germ cell-free protein synthesis system.

Mol Biosyst.., 2015; 11:361-365
DOI:10.1039/c4mb00556b
Takemori N, Takemori A, Matsuoka K, Morishita R, Matsushita N, Aoshima M, Takeda H, Sawasaki T, Endo Y, Higashiyama S.

英文原著 MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response.

Cell Rep.., 2015; 10:1722-1734
DOI:10.1016/j.celrep.2015.02.030
James SJ, Jiao H, Teh HY, Takahashi H, Png CW, Phoon MC, Suzuki Y, Sawasaki T, Xiao H, Chow VT, Yamamoto N, Reynolds JM, Flavell RA, Dong C, Zhang Y.

英文原著 AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity.

FASEB J.., 2014; 28(7):3211-24
DOI:10.1096/fj.14-250449
Lantier L, Fentz J, Mounier R,Leclerc J, Treebak JT, Pehmøller C, Sanz N, Sakakibara I, Saint-Amand E,Rimbaud S, Maire P, Marette A, Ventura-Clapier R,Ferry A, Wojtaszewski JF, Foretz M, Viollet B.

英文原著 Fatostatin, an SREBP inhibitor, prevented RANKL-induced bone loss by suppression of osteoclast differentiation.

BBA-Molecular Basis of Disease.., 2015; 1852(11):2432-41
DOI:10.1016/j.bbadis.2015.08.018
Inoue K and Imai Y.

英文原著 ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease.

Am J Physiol Renal Physiol.., 2014; 307(5):F551-9
DOI:10.1152/ajprenal.00218.2014
Beck Gooz M, Maldonado EN, Dang Y, Amria MY, Higashiyama S, Abboud HE, Lemasters JJ, Bell PD

英文原著 Pathophysiology of lung injury induced by common bile duct ligation in mice.

PLoS One.., 2014; 9(4):e94550
DOI:10.1371/journal.pone.0094550
Shikata F, Sakaue T, Nakashiro K, Okazaki M, Kurata M, Okamura T, Okura M, Ryugo M, Nakamura Y, Yasugi T, Higashiyama S, Izutani H

英文原著 Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage.

Proc Natl Acad Sci U S A.., 2014; 111(2):717-22
DOI:10.1073/pnas.1313675111
Taira N, Yamaguchi T, Kimura J, Lu ZG, Fukuda S, Higashiyama S, Ono M, Yoshida K

英文原著 Genome-wide comprehensive analysis reveals critical cooperation between Smad and c-Fos in RANKL-induced osteoclastogenesis.

J Bone Miner Res.., 2015; 30(5):869-77
DOI:10.1002/jbmr.2418
Omata Y, Yasui T, Hirose J, Izawa N, Imai Y, Matsumoto T, Masuda H, Tokuyama N, Nakamura S, Tsutsumi S, Yasuda H, Okamoto K, Takayanagi H, Hikita A, Imamura T, Matsuo K, Saito T, Kadono Y, Aburatani H, Tanaka S.

英文原著 Biofunction-assisted aptasensors based on ligand-dependent 3’ processing of a suppressor tRNA in a wheat germ extract

Org. Biomol. Chem.., 2015; 13(24):6681-6685
DOI:10.1039/C5OB00794A
Ogawa A, Tabuchi J

英文原著 Fate, origin and roles of cells within free bone grafts.

J Orthop Sci., 2015; 20(2):390-6
DOI:10.1007/s00776-014-0673-5
Yano K, Yasuda H, Takaoka K, Takahashi M, Nakamura H, Imai Y, Wakitani S.