研究業績｜愛媛大学プロテオサイエンスセンター

英文原著 Safety and efficacy of an anti-claudin-5 monoclonal antibody to increase blood–brain barrier permeability for drug delivery to the brain in a non-human primate.

J Control Release.， 2021； 336：105-111

DOI:10.1016/j.jconrel.2021.06.009

Keisuke Tachibana, Yosuke Hashimoto, Keisuke Shirakura, Yoshiaki Okada, Ryuichi Hirayama, Yumi Iwashita, Itsuki Nishino, Yukio Ago, Hiroyuki Takeda, Hiroki Kuniyasu, Masuo Kondoh

英文原著 Plasmodium yoelii Erythrocyte Binding Like Protein Interacts With Basigin, an Erythrocyte Surface Protein

Frontiers in cellular and infection microbiology.， 2021； 11：656620-656620

DOI:10.3389/fcimb.2021.656620

Takaaki Yuguchi, Bernard N Kanoi, Hikaru Nagaoka, Toyokazu Miura, Daisuke Ito, Hiroyuki Takeda, Takafumi Tsuboi, Eizo Takashima, Hitoshi Otsuki

英文原著 A comprehensive interaction study provides a potential domain interaction network of human death domain superfamily proteins

Cell death and differentiation.， 2021；：

DOI:10.1038/s41418-021-00796-x

Wei Zhou, Naoe Kaneko, Tomoya Nakagita, Hiroyuki Takeda, Junya Masumoto

英文原著 Early origin of sweet perception in the songbird radiation

Science.， 2021； 373：226-231

DOI:10.1126/science.abf6505

Toda Y, Ko MC, Liang Q, Miller ET, Rico-Guevara A, Nakagita T, Sakakibara A, Uemura K, Sackton T, Hayakawa T, Sin SYW, Ishimaru Y, Misaka T, Oteiza P, Crall J, Edwards SV, Buttemer W, Matsumura S, Baldwin MW.

英文原著 Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells

Journal of Experimental Medicine.， 2021； 218(7)：e20201763

DOI:10.1084/jem.20201763

Miwa Sasai, Ji Su Ma, Masaaki Okamoto, Kohei Nishino, Hikaru Nagaoka, Eizo Takashima, Ariel Pradipta, Youngae Lee, Hidetaka Kosako, Pann-Ghill Suh, Masahiro Yamamoto

英文原著 CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP.

Life Sci Alliance..， 2021； 4 (9)：e202101095

DOI:10.26508/lsa.202101095

Nishiyama K, Maekawa M, Nakagita T, Nakayama J, Kiyoi T, Chosei M, Murakami A, Kamei Y, Takeda H, Takada Y, Higashiyama S.

英文原著 Estrogen receptor α in mature osteoblasts regulates the late stage of bone regeneration

Biochem Biophys Res Commun..， 2021； 559：238-244

DOI:10.1016/j.bbrc.2021.04.112

Ikedo A, Imai Y.

英文原著 A Detailed Protocol for Preparing Millimeter-Sized Supergiant Liposomes That Permit Efficient Eukaryotic Cell-Free Translation in the Interior

Bio-protocol.， 2021； 11：e4054

DOI:10.21769/BioProtoc.4054

Takahashi H, Ogawa A

英文原著 The association between renal elasticity evaluated by Real-time tissue elastography and renal fibrosis

Clin Exp Nephrol..， 2021； Online ahead of print：Online ahead of print

DOI:10.1007/s10157-021-02063-2

Ayu Makita, Tomoaki Nagao, Ken-Ichi Miyoshi, Yohei Koizumi, Mie Kurata, Fumikazu Kondo, Satoru Shichijo, Masashi Hirooka, Osamu Yamaguchi

英文原著 Non-microtubule tubulin-based backbone and subordinate components of postsynaptic density lattices

Life Sci. Alliance.， 2021； 4：e202000945

DOI:10.26508/lsa.202000945

Suzuki T, Terada N, Higashiyama S, Kametani K, Shirai Y, Honda M, Kai T, Li W, Tabuchi K.

英文原著 Active aneurysm thrombosis after Kawasaki disease in an adult: Insight into anticoagulation therapy

J Cardiol Cases..， 2021； 23(5)：206-209.

DOI:10.1016/j.jccase.2020.11.005

Akazawa Y, Inaba S, Sakaue T, Kurata M, Aono J, Yasugi T, Moritani T, Nishiyama H, Higaki T, Eguchi M, Yamaguchi O.

英文原著 Functionally confirmed compound heterozygous ADAM17 missense loss-of-function variants cause neonatal inflammatory skin and bowel disease 1

Sci Rep..， 2021； 11：9552

DOI:10.1038/s41598-021-89063-0

Imoto I, Saito M, Suga K, Kohmoto T, Otsu M, Horiuchi K, Nakayama H, Higashiyama S, Sugimoto M, Sasaki A, Homma Y, Shono M, Nakagawa R, Hayabuchi Y, Tange S, Kagami S, Masuda K

英文原著 Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4

iScience..， 2021； 24(4)：102303

DOI:10.1016/j.isci.2021.102303

Sakakibara I, Yanagihara Y, Himori K, Yamada T, Sakai H, Sawada Y, Takahashi H, Saeki N, Hirakawa H, Yokoyama A, Fukada S, Sawasaki T, Imai Y.

英文原著 Molecular detection using aptamer-modified gold nanoparticles with an immobilized DNA brush for the prevention of non-specific aggregation

RSC Adv..， 2021； 11：11984-11991

DOI:10.1039/D0RA05149G

Yano-Ozawa Y, Lobsiger N, Muto Y, Mori T, Yoshimura K, Yano Y, Stark WJ, Maeda M, Asahi T, Ogawa A, Zako T

英文原著 Topical co-administration of zoledronate with recombinant human bone morphogenetic protein-2 can induce and maintain bone formation in the bone marrow environment

BMC Musculoskelet Disord..， 2021； 22(1)：94

DOI:10.1186/s12891-021-03971-w

Ueyama H, Ohta Y, Imai Y, Suzuki A, Sugama R, Minoda Y, Takaoka K, Nakamura H.

英文原著 A single-chain antibody generation system yielding CAR-T cells with superior antitumor function

Communications Biology.， 2021； 4：Article number 273

DOI:10.1038/s42003-021-01791-1

Toshiki Ochi, Masaki Maruta, Kazushi Tanimoto, Fumitake Kondo, Toshihiro Yamamoto, Mie Kurata, Hiroshi Fujiwara, Junya Masumoto, Katsuto Takenaka, Masaki Yasukawa

英文原著 Roles of Pyk2 in signal transduction after gonadotropin‐releasing hormone receptor stimulation.

J. Cell. Physiol..， 2021； 236(4)：3033-3043.

DOI:10.1002/jcp.30077

Okitsu-Sakurayama S, Higa-Nakamine S, Torihara H, Higashiyama S, Yamamoto H

英文原著 Thalidomide and its metabolite 5‐hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF

EMBO J.， 2021；：e105375

DOI:10.15252/embj.2020105375

Satoshi Yamanaka, Hidetaka Murai, Daisuke Saito, Gembu Abe, Etsuko Tokunaga, Takahiro Iwasaki, Hirotaka Takahashi, Hiroyuki Takeda, Takayuki Suzuki, Norio Shibata, Koji Tamura, Tatsuya Sawasaki

英文原著 Pathological Evidence of Native Aortic Valve Injury After Impella Support.

Circ Heart Fail..， 2021； 14(2)：e007571

DOI:10.1161/CIRCHEARTFAILURE.120.007571

Higashi H, Nishimura T, Aono J, Sakaue T, Kurata M, Izutani H, Yamaguchi O

英文原著 Protective Effect of Ferulic Acid against Hydrogen Peroxide Induced Apoptosis in PC12 Cells

Molecules..， 2020； 26(1)：E90

DOI:10.3390/molecules26010090

Nakayama H, Nakahara M, Matsugi E, Soda M, Hattori T, Hara K, Usami A, Kusumoto C, Higashiyama S, Kitaichi K.

ACHIEVEMENTS 研究業績

SEARCH ACHIEVEMENTS