{"id":149,"date":"2022-08-17T18:08:21","date_gmt":"2022-08-17T09:08:21","guid":{"rendered":"https:\/\/proteincomplex.wordpress.com\/?page_id=149"},"modified":"2025-08-21T11:45:09","modified_gmt":"2025-08-21T02:45:09","slug":"research","status":"publish","type":"page","link":"https:\/\/www.pros.ehime-u.ac.jp\/protein-complex\/?page_id=149","title":{"rendered":"\u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"\n
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  1. Sci. Signal<\/em>., 12(611)<\/strong>. pii: eaaw5505 (2019). \u2192\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a><\/li>\n\n\n\n
  2. Protein Pept. Lett.<\/em> 26<\/strong>, 792-797 (2019).<\/li>\n\n\n\n
  3. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun<\/em>. 75<\/strong>, 116-122 (2019).<\/li>\n\n\n\n
  4. Sci. Rep<\/em>. 7<\/strong>, 7739 (2017).<\/li>\n\n\n\n
  5. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun<\/em>. 67<\/strong>, 758-761 (2011)<\/li>\n<\/ol>\n<\/div>\n\n\n\n
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    \u53c2\u8003\u6587\u732e\u306a\u3069<\/h2>\n\n\n\n
      \n
    1. Genes Cells<\/em>, 20<\/strong>, 847-859 (2015).<\/em><\/li>\n\n\n\n
    2. EMBO J<\/em>. 29<\/strong>, 236-250 (2010)<\/li>\n\n\n\n
    3. J. Biol. Chem.<\/em> 283<\/strong>, 29602-29612 (2008)<\/li>\n\n\n\n
    4. J. Mol. Biol.<\/em> 381<\/strong>, 634-644 (2008)<\/li>\n\n\n\n
    5. Genes Cells<\/em> 12<\/strong>, 1329-1338 (2007)<\/li>\n\n\n\n
    6. J. Biol. Chem.<\/em> 282<\/strong>, 19854-19862 (2007)<\/li>\n\n\n\n
    7. Structure<\/em> 14<\/strong>, 777-789(2006)<\/li>\n<\/ol>\n\n\n\n
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      2. <\/span>\u795e\u7d4c\u7cfb\u306e\u767a\u751f\u304a\u3088\u3073\u9ad8\u6b21\u306e\u751f\u547d\u6a5f\u80fd\u3092\u62c5\u3046\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb<\/span><\/h2>\n\n\n\n
      <\/div>\n\n\n\n

      \u2460\u5fae\u5c0f\u7ba1\u3092\u4ecb\u3057\u305f\u30c0\u30a4\u30cb\u30f3\u306b\u3088\u308b\u9006\u884c\u6027\u7269\u8cea\u8f38\u9001\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb<\/h2>\n\n\n\n

      \u7d30\u80de\u306e\u4e2d\u306b\u306f\u3001\u69d8\u3005\u306a\u7d30\u80de\u5c0f\u5668\u5b98\u304c\u3042\u308a\u3001\u3053\u308c\u3089\u306e\u5668\u5b98\u304c\u6b63\u3057\u304f\u6a5f\u80fd\u3059\u308b\u305f\u3081\u306b\u306f\u53d7\u5bb9\u4f53\u306a\u3069\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u62c5\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7cbe\u5bc6\u306a\u8f38\u9001\u304c\u6975\u3081\u3066\u91cd\u8981\u3067\u3059\u3002\u7279\u306b\u7d30\u80de\u819c\u304b\u3089\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u306b\u3088\u308a\u7d30\u80de\u5185\u306b\u53d6\u308a\u8fbc\u307e\u308c\u305f\u53d7\u5bb9\u4f53\u306f\u3001\u5c0f\u80de\u8f38\u9001\u306b\u3088\u3063\u3066\u30ea\u30b5\u30a4\u30af\u30eb\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7d30\u80de\u5185\u5c0f\u80de\u8f38\u9001\u306f\u3001\u5fae\u5c0f\u7ba1\u306b\u6cbf\u3063\u305f\u8f38\u9001\u304c\u4e2d\u5fc3\u3067\u3042\u308a\u3001\u5c0f\u80de\u4f53\u304b\u3089\u7d30\u80de\u819c\u5074\u3078\u3068\u8f38\u9001\u3059\u308b\u9806\u884c\u6027\u8f38\u9001\u3068\u7d30\u80de\u819c\u5074\u304b\u3089\u5c0f\u80de\u4f53\u3078\u3068\u8f38\u9001\u3059\u308b\u9006\u884c\u6027\u8f38\u9001\u304c\u3042\u308a\u307e\u3059\u3002\u30c0\u30a4\u30cb\u30f3\u306a\u3069\u306e\u30e2\u30fc\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u9006\u884c\u6027\u8f38\u9001\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u907a\u4f1d\u7684\u306a\u6a5f\u80fd\u6b20\u640d\u306b\u3088\u308a\u7b4b\u840e\u7e2e\u75c7\u306a\u3069\u306e\u75be\u60a3\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u5ba4\u3067\u306f\u3001\u30b4\u30eb\u30b8\u4f53-\u5c0f\u80de\u4f53\u9593\u306e\u9006\u884c\u6027\u8f38\u9001\u3092\u5236\u5fa1\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u306e\u7acb\u4f53\u69cb\u9020\u6c7a\u5b9a\u3092\u304a\u3053\u306a\u3044\u3001\u8f38\u9001\u3055\u308c\u308b\u5206\u5b50\u306e\u9078\u5225\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u304a\u3053\u306a\u308f\u308c\u3066\u3044\u308b\u306e\u304b\u3092\u539f\u5b50\u30ec\u30d9\u30eb\u3067\u89e3\u660e\u3057\u3066\u3001\u75be\u60a3\u767a\u75c7\u306e\u539f\u56e0\u306e\u7406\u89e3\u3092\u76ee\u6307\u3057\u305f\u7814\u7a76\u3092\u304a\u3053\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

      \u3000\u73fe\u5728\u306f\u3001\u54fa\u4e73\u985eBICD1\u306eC\u672b\u7aef\u30c9\u30e1\u30a4\u30f3\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u6a19\u7684\u3068\u306a\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u8a8d\u8b58\u3057\u7d50\u5408\u3059\u308b\u306e\u304b\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u3001BICD1\u3068\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u306e\u8907\u5408\u4f53\u306e\u7acb\u4f53\u69cb\u9020\u89e3\u6790\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

      <\/div>\n\n\n\n
      \n
      \n
      \"\"<\/figure>\n<\/div>\n\n\n\n
      \n
      \"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n
      <\/div>\n\n\n\n

      \u53c2\u8003\u6587\u732e\u306a\u3069<\/h2>\n\n\n\n
        \n
      1. Biochem. Biophys. Res. Commun.<\/em> 460<\/strong>, 451-456 (2015).<\/em><\/em><\/li>\n\n\n\n
      2. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun<\/em>. 70,<\/strong> 1103-1106 (2014)<\/li>\n<\/ol>\n\n\n\n
        <\/div>\n<\/div>\n\n\n\n
        \n

        \u2461\u795e\u7d4c\u7d30\u80de\u306e\u767a\u751f\u30fb\u6210\u719f\u5316\u3092\u62c5\u3046\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb<\/h2>\n\n\n\n

        \u795e\u7d4c\u7d30\u80de\u306e\u8ef8\u7d22\u306e\u5468\u308a\u306b\u4f5c\u3089\u308c\u308b\u9ac4\u9798(\u30df\u30a8\u30ea\u30f3)\u306f\u3001\u795e\u7d4c\u7d30\u80de\u9593\u306e\u96fb\u6c17\u4f1d\u5c0e\u901f\u5ea6\u3092\u4e0a\u6607\u3055\u305b\u308b\u5f79\u5272\u3092\u6301\u3064\u91cd\u8981\u306a\u69cb\u9020\u4f53\u3067\u3059\u304c\u304c\u3001\u3069\u306e\u3088\u3046\u306a\u4ed5\u7d44\u307f\u3067\u5f62\u6210\u3055\u308c\u308b\u306e\u304b\u306f\u4e0d\u660e\u306a\u70b9\u304c\u591a\u304f\u6b8b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u3001G\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5236\u5fa1\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u3092\u7814\u7a76\u5bfe\u8c61\u3068\u3057\u3066\u3001\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u5236\u5fa1\u306e\u4ed5\u7d44\u307f\u3092\u89e3\u660e\u3059\u308b\u3053\u3068\u3067\u3001\u795e\u7d4c\u7cfb\u6210\u719f\u5316\u306e\u4ed5\u7d44\u307f\u3092\u7406\u89e3\u3057\u3001\u795e\u7d4c\u96e3\u75c5\u306b\u5bfe\u3059\u308b\u5275\u85ac\u6280\u8853\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u305f\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059(\u73fe\u5728\u9032\u884c\u4e2d)\u3002<\/p>\n<\/div>\n\n\n\n

        \n

        3. \u907a\u4f1d\u5b50\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u306e\u5206\u5b50\u6a5f\u80fd\u89e3\u6790<\/span><\/h2>\n\n\n\n

        \u7d30\u80de\u3067\u306f\u3001DNA\u304b\u3089mRNA\u304c\u8ee2\u5199\u3055\u308c\u3066\u3001\u305d\u306emRNA\u3092\u5229\u7528\u3057\u3066\u30ea\u30dc\u30bd\u30fc\u30e0\u306b\u3088\u3063\u3066\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7ffb\u8a33\u3055\u308c\u307e\u3059\u3002\u30d2\u30c8\u306a\u3069\u306e\u9ad8\u7b49\u751f\u7269\u3067\u306f\u3001\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3068\u3044\u3046\u5206\u5b50\u6a5f\u69cb\u3092\u901a\u3057\u3066mRNA\u3092\u7de8\u96c6\u3057\u3001\u4e00\u3064\u306e\u907a\u4f1d\u5b50\u304b\u3089\u8907\u6570\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u5206\u5b50\u6a5f\u69cb\u306e\u5b9f\u614b\u306f\u4e0d\u660e\u306a\u70b9\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001RNA\u306e\u8ee2\u5199\u3092\u5236\u5fa1\u3059\u308b\u8ee2\u5199\u56e0\u5b50\u7fa4\u306e\u5206\u5b50\u6a5f\u80fd\u306b\u3064\u3044\u3066\u3082\u4e0d\u660e\u306a\u70b9\u304c\u6b8b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u5ba4\u3067\u306f\u3001\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3092\u5236\u5fa1\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u3084\u6838\u5185\u53d7\u5bb9\u4f53\u7b49\u306e\u8ee2\u5199\u56e0\u5b50\u7fa4\u306e\u7acb\u4f53\u69cb\u9020\u89e3\u6790\u3092\u901a\u3057\u3066\u3001\u9ad8\u7b49\u751f\u7269\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u5206\u5b50\u6a5f\u69cb\u306b\u95a2\u3059\u308b\u7814\u7a76\u3092\u304a\u3053\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7814\u7a76\u306f\u3001\u7fa4\u99ac\u5927\u5b66\u304a\u3088\u3073\u6b66\u8535\u91ce\u5927\u5b66\u3068\u5354\u529b\u3057\u3066\u304a\u3053\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

        \n
        \"\"
        \u30b9\u30d7\u30e9\u30a4\u30bd\u30bd\u30fc\u30e0\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3068\u6a19\u7684RNA\u3068\u306e\u8907\u5408\u4f53\u306e\u7acb\u4f53\u69cb\u9020<\/figcaption><\/figure>\n<\/figure>\n<\/div>\n\n\n\n
        \n
        \n
        \n
        \n
        \n

        \u53c2\u8003\u6587\u732e\u306a\u3069<\/h2>\n\n\n\n
          \n
        1. J. Biochem<\/em>. (2023), 174(2):203-216. doi: 10.1093\/jb\/mvad033<\/li>\n\n\n\n
        2. J. Biochem<\/em>. (2023), 173(5):393-411. doi: 10.1093\/jb\/mvad005.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

          \u7814\u7a76\u5185\u5bb9 \u7d30\u80de\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u5236\u5fa1\u306e\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e \u30d2\u30c8\u306a\u3069\u306e\u9ad8\u7b49\u751f\u7269\u306f\u3001\u7d30\u80de\u306e\u5897\u6b96\u3001\u5206\u5316\u3001\u904b\u52d5\u306a\u3069\u306e\u7d30\u80de\u6a5f\u80fd\u3092\u5916\u90e8\u74b0\u5883\u306b\u9069\u5fdc\u3057\u3066\u5236\u5fa1\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u3053\u3067\u306f\u3001\u7d30\u80de\u819c\u306b\u57cb\u3081\u8fbc\u307e\u308c\u305f\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u53d7\u5bb9\u4f53\u3084\u7d30\u80de\u5185\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u95a2\u4e0e\u3057\u3066\u3044 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"sidebar-footer-only","meta":{"footnotes":""},"class_list":["post-149","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.pros.ehime-u.ac.jp\/protein-complex\/index.php?rest_route=\/wp\/v2\/pages\/149","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pros.ehime-u.ac.jp\/protein-complex\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pros.ehime-u.ac.jp\/protein-complex\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pros.ehime-u.ac.jp\/protein-complex\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pros.ehime-u.ac.jp\/protein-complex\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=149"}],"version-history":[{"count":15,"href":"https:\/\/www.pros.ehime-u.ac.jp\/protein-complex\/index.php?rest_route=\/wp\/v2\/pages\/149\/revisions"}],"predecessor-version":[{"id":1345,"href":"https:\/\/www.pros.ehime-u.ac.jp\/protein-complex\/index.php?rest_route=\/wp\/v2\/pages\/149\/revisions\/1345"}],"wp:attachment":[{"href":"https:\/\/www.pros.ehime-u.ac.jp\/protein-complex\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}