{"id":857,"date":"2026-03-22T11:25:19","date_gmt":"2026-03-22T02:25:19","guid":{"rendered":"https:\/\/www.pros.ehime-u.ac.jp\/Interactome\/?page_id=857"},"modified":"2026-04-07T11:30:54","modified_gmt":"2026-04-07T02:30:54","slug":"%e7%a0%94%e7%a9%b6%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%ef%bc%88%e3%81%8f%e3%82%8f%e3%81%97%e3%81%8f%ef%bc%89%ef%bc%88%e6%96%87%e5%ad%97%e3%81%a0%e3%81%91%ef%bc%89","status":"publish","type":"page","link":"https:\/\/www.pros.ehime-u.ac.jp\/Interactome\/yamanakalab\/%e7%a0%94%e7%a9%b6%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%ef%bc%88%e3%81%8f%e3%82%8f%e3%81%97%e3%81%8f%ef%bc%89%ef%bc%88%e6%96%87%e5%ad%97%e3%81%a0%e3%81%91%ef%bc%89\/","title":{"rendered":"\u304f\u308f\u3057\u3044\u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"\n<div style=\"max-width: 900px; margin: 0 auto; width: 100%;\">\n    <div class=\"section-title\" id=\"research-topics\">\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n   <div style=\"text-align:center; margin:20px 0;\">\n <h3>1. \u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u85ac\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76<\/h3>\n    <\/div>\n<article class=\"research-item\">\n      <h4 class=\"subhead\"><\/h4>\n      <ul><p>\n        \u5f93\u6765\u306e\u4f4e\u5206\u5b50\u533b\u85ac\u54c1\u306f\u3001\u7d30\u80de\u5185\u3067\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u9175\u7d20\u6d3b\u6027\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u4f5c\u7528\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u8fd1\u5e74\u3001\u4f4e\u5206\u5b50\u5316\u5408\u7269\u304c\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5206\u89e3\u3092\u8a98\u5c0e\u3057\u3066\u4f5c\u7528\u3059\u308b\u4f8b\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u3001\u3053\u306e\u3088\u3046\u306a\u5316\u5408\u7269\u7fa4\u306f\u300c\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u85ac\u300d\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002<br>\n\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u85ac\u306f\u3001<br>\n<h5 style=\"padding-left: 3em;\">1). \u89e6\u5a92\u7684\u306b\u4f5c\u7528\u3057\u4f4e\u6fc3\u5ea6\u3067\u5f37\u529b\u306a\u52b9\u679c\u3092\u793a\u3059\u3001<br>\n                                2). \u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5168\u6a5f\u80fd\u3092\u6291\u5236\u3059\u308b\u3001<br>\n                                3). \u9175\u7d20\u6d3b\u6027\u3092\u6301\u305f\u306a\u3044Undruggable\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3082\u9069\u7528\u53ef\u80fd\u3067\u3042\u308b<\/h5><br>\n\u3068\u3044\u3063\u305f\u7279\u5fb4\u3092\u6301\u3061\u3001\u6b21\u4e16\u4ee3\u306e\u5275\u85ac\u30e2\u30c0\u30ea\u30c6\u30a3\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u85ac\u306b\u7126\u70b9\u3092\u5f53\u3066\u3001\u591a\u89d2\u7684\u306a\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\n      <\/ul><\/p>\n    <\/article>\n\n\n<figure class=\"wp-block-image size-large is-resized\" style=\" padding: 40px 0px 40px 40px;\">\n   <img decoding=\"async\" src=\"https:\/\/www.pros.ehime-u.ac.jp\/Interactome\/wp-content\/uploads\/2026\/03\/HP-\u56f32-06-2-scaled-e1774508479759.png\" \n      alt=\"\u5206\u89e3\u85ac\u30ea\u30b5\u30a4\u30af\u30eb\" \n      style=\"width:860px; height:auto; display:block;\"\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n   <article class=\"research-item1-1\">\n      <h4 class=\"subhead\">\u2460\t\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u306e\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e<\/h4>\n      <ul>\n        <p>\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u306f1950\u5e74\u4ee3\u306b\u598a\u5a66\u306b\u5bfe\u3059\u308b\u50ac\u7720\u5264\u3068\u3057\u3066\u4f7f\u308f\u308c\u307e\u3057\u305f\u304c\u3001\u80ce\u5150\u306b\u91cd\u7be4\u306a\u50ac\u5947\u6027\u3092\u5f15\u304d\u8d77\u3053\u3057\u305f\u3053\u3068\u3067\u5927\u898f\u6a21\u306a\u85ac\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u3001\u8840\u6db2\u304c\u3093\u3084\u30cf\u30f3\u30bb\u30f3\u75c5\u3078\u306e\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u3001\u518d\u8a8d\u53ef\u3055\u308c\u307e\u3057\u305f\u3002\u73fe\u5728\u306f\u3001\u8a98\u5c0e\u4f53\u306e\u30ec\u30ca\u30ea\u30c9\u30df\u30c9\u3084\u30dd\u30de\u30ea\u30c9\u30df\u30c9\u304c\u591a\u767a\u6027\u9aa8\u9ac4\u816b\u306a\u3069\u306e\u6cbb\u7642\u306b\u5e83\u304f\u4f7f\u308f\u308c\u3066\u3044\u307e\u3059\u3002\n<br>\n\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u306e\u4f5c\u7528\u6a5f\u69cb\u306f\u534a\u4e16\u7d00\u4ee5\u4e0a\u306e\u9593\u672a\u89e3\u660e\u3067\u3057\u305f\u304c\u3001\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u3001\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u3084\u8a98\u5c0e\u4f53\u306fCRL4\u8907\u5408\u4f53\u306e\u53d7\u5bb9\u4f53\u3067\u3042\u308b\u30bb\u30ec\u30d6\u30ed\u30f3\uff08CRBN\uff09\u306b\u7d50\u5408\u3057\u3001\u6a19\u7684\u3067\u306a\u3044\u300c\u30cd\u30aa\u57fa\u8cea\u300d\u306e\u5206\u89e3\u3092\u8a98\u5c0e\u3059\u308b\u300c\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u85ac\u300d\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u6297\u8840\u6db2\u304c\u3093\u4f5c\u7528\u3084\u50ac\u5947\u6027\u3092\u793a\u3059\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u306f\u57fa\u76e4\u6280\u8853\u3092\u6d3b\u7528\u3057\u3001\u30cd\u30aa\u57fa\u8cea\u306e\u63a2\u7d22\u3092\u9032\u3081\u3001\u50ac\u5947\u6027\u306b\u95a2\u4e0e\u3059\u308bPLZF\u306a\u3069\u3092\u540c\u5b9a\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u73fe\u5728\u3082\u4f5c\u7528\u6a5f\u69cb\u3084\u65b0\u898f\u30cd\u30aa\u57fa\u8cea\u306e\u89e3\u660e\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\t\t<\/ul>\n    <\/article>\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n   <article class=\"research-item1-2\">\n      <h4 class=\"subhead\">\u2461\t\u65b0\u305f\u306a\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u8a98\u5c0e\u4f53\u306e\u958b\u767a<\/h4>\n      <ul>\n        <p>\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u3084\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u8a98\u5c0e\u4f53\u306f\u3001\u4e3b\u306bC2H2\u30bf\u30a4\u30d7\u306e\u30b8\u30f3\u30af\u30d5\u30a3\u30f3\u30ac\u30fc\u30c9\u30e1\u30a4\u30f3\u3092\u6301\u3064\u8ee2\u5199\u56e0\u5b50\u3092\u5206\u89e3\u8a98\u5c0e\u3057\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u5206\u89e3\u53ef\u80fd\u306a\u6a19\u7684\u306f\u9650\u3089\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u8fd1\u5e74\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u7279\u5b9a\u306e\u7acb\u4f53\u69cb\u9020\u3092\u6301\u3064\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308c\u3070\u5206\u89e3\u8a98\u5c0e\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u69cb\u9020\u3092\u6301\u3064\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u30d2\u30c8\u30d7\u30ed\u30c6\u30aa\u30fc\u30e0\u306b2500\u7a2e\u985e\u4ee5\u4e0a\u5b58\u5728\u3059\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u306fCRBN\u306b\u7d50\u5408\u3059\u308b\u5316\u5b66\u69cb\u9020\u3092\u6709\u3059\u308b\u5316\u5408\u7269\u3092\u9ad8\u5ea6\u306b\u4fee\u98fe\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u591a\u69d8\u306a\u6a19\u7684\u3092\u5206\u89e3\u8a98\u5c0e\u3067\u304d\u308b\u53ef\u80fd\u6027\u3092\u8ffd\u6c42\u3057\u3001\u50ac\u5947\u6027\u3092\u6291\u3048\u3064\u3064\u6297\u304c\u3093\u4f5c\u7528\u3092\u793a\u3059\u65b0\u305f\u306a\u30ec\u30ca\u30ea\u30c9\u30df\u30c9\u8a98\u5c0e\u4f53\u3092\u958b\u767a\u3057\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u3082CRBN\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u898f\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u85ac\u306e\u958b\u767a\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n      <\/ul>\n    <\/article>\n\n<figure class=\"wp-block-image size-large is-resized\" style=\" padding: 40px 0px 40px 40px;\">\n   <img decoding=\"async\" src=\"https:\/\/www.pros.ehime-u.ac.jp\/Interactome\/wp-content\/uploads\/2026\/03\/HP-\u56f32-08-1.png\" \n      alt=\"\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u5316\u5b66\u69cb\u9020\" \n      style=\"width:860px; height:auto; display:block;\"\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<div style=\"max-width: 900px; margin: 0 auto; width: 100%;\">\n   <article class=\"research-item1\">\n      <h4 class=\"subhead\">\u2462\t\u30ad\u30e1\u30e9\u578b\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u85ac\u306e\u958b\u767a<\/h4>\n      <ul>\n        <p>\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u85ac\u306f\u3001\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u306e\u3088\u3046\u306a\u300c\u5206\u5b50\u7cca\u578b\u300d\u3068\u3001E3\u30ea\u30ac\u30fc\u30bc\u7d50\u5408\u5316\u5408\u7269\uff08E3\u30d0\u30a4\u30f3\u30c0\u30fc\uff09\u3068\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u7d50\u5408\u5316\u5408\u7269\uff08\u6a19\u7684\u30d0\u30a4\u30f3\u30c0\u30fc\uff09\u3092\u5316\u5b66\u7684\u306b\u9023\u7d50\u3057\u305f\u300c\u30ad\u30e1\u30e9\u578b\u300d\u306b\u5927\u5225\u3055\u308c\u307e\u3059\u3002\u5f8c\u8005\u306fPROteolysis Targeting Chimera\uff08PROTAC\uff09\u3068\u547c\u3070\u308c\u3001\u6a19\u7684\u30d0\u30a4\u30f3\u30c0\u30fc\u3092\u5909\u66f4\u3059\u308b\u3053\u3068\u3067\u591a\u69d8\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5206\u89e3\u8a98\u5c0e\u53ef\u80fd\u306a\u9769\u65b0\u7684\u30e2\u30c0\u30ea\u30c6\u30a3\u3067\u3059\u3002\u3059\u3067\u306b\u3044\u304f\u3064\u304b\u306ePROTAC\u306f\u81e8\u5e8a\u8a66\u9a13\u3067\u6709\u52b9\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u69cb\u9020\u306b\u7531\u6765\u3059\u308b\u30cd\u30aa\u57fa\u8cea\u306e\u5206\u89e3\u306b\u3088\u308b\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u304c\u3042\u308a\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u72ec\u81ea\u306e\u30ec\u30ca\u30ea\u30c9\u30df\u30c9\u8a98\u5c0e\u4f53\u3092CRBN\u30d0\u30a4\u30f3\u30c0\u30fc\u3068\u3057\u3066\u7528\u3044\u3001\u30cd\u30aa\u57fa\u8cea\u5206\u89e3\u3092\u5236\u5fa1\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u73fe\u5728\u3001\u65b0\u305f\u306aCRBN\u30d0\u30a4\u30f3\u30c0\u30fc\u3084\u4ed6\u306eE3\u30d0\u30a4\u30f3\u30c0\u30fc\u306e\u63a2\u7d22\u3092\u9032\u3081\u3001\u5b89\u5168\u3067\u6709\u52b9\u306aPROTAC\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n      \n\t\t<\/ul>\n    <\/article>\n\n<figure class=\"wp-block-image size-large is-resized\" style=\" padding: 40px 0px 40px 40px;\">\n   <img decoding=\"async\" src=\"https:\/\/www.pros.ehime-u.ac.jp\/Interactome\/wp-content\/uploads\/2026\/03\/HP-\u56f32-09.png\" \n      alt=\"PROTAC\u5316\u5b66\u69cb\u9020\" \n      style=\"width:860px; height:auto; display:block;\"\n\n\n\t<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n\n\n<hr>\n\n\n\n<div style=\"max-width: 900px; margin: 0 auto; width: 100%;\">\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<hr>\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n   <div class=\"section-title\" id=\"research-topics2\">\n   <div style=\"text-align:center; margin:20px 0;\">\n      <h3>2. \u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u8a98\u5c0e\u9175\u7d20\u3092\u5bfe\u8c61\u306b\u3057\u305f\u7814\u7a76<\/h3>\n\n    <\/div>\n\n<article class=\"research-item2\">\n      <h4 class=\"subhead\"><\/h4>\n      <ul>\n        \u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u85ac\u306e\u7814\u7a76\u306f\u6025\u901f\u306b\u62e1\u5927\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u6a19\u7684\u3068\u306a\u308bE3\u30ea\u30ac\u30fc\u30bc\u306e\u751f\u7406\u7684\u6a5f\u80fd\u306f\u5341\u5206\u306b\u7406\u89e3\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<br>\n\u4f8b\u3048\u3070\u3001\u6700\u3082\u7814\u7a76\u304c\u9032\u3093\u3067\u3044\u308bCRBN\u3067\u3055\u3048\u3001\u5185\u5728\u6027\u57fa\u8cea\u3084\u751f\u7406\u7684\u6a5f\u80fd\u306b\u306f\u4e0d\u660e\u306a\u70b9\u304c\u591a\u304f\u6b8b\u3063\u3066\u3044\u307e\u3059\u3002<br>\n\u79c1\u305f\u3061\u306fE3\u30ea\u30ac\u30fc\u30bc\u306b\u6ce8\u76ee\u3057\u3001\u305d\u306e\u57fa\u8cea\u3084\u6a5f\u80fd\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3067\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u85ac\u306e\u958b\u767a\u3084\u9069\u5207\u306a\u5229\u7528\u306b\u8ca2\u732e\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\n      <\/ul>\n    <\/article>\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>  \n\n<article class=\"research-item2-1\">\n      <h4 class=\"subhead\">\u2460\tDCAF\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u6a5f\u80fd\u89e3\u6790<\/h4>\n      <ul>\n        <p>\u5206\u5b50\u7cca\u578b\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u85ac\u306e\u591a\u304f\u306f\u3001E3\u30e6\u30d3\u30ad\u30c1\u30f3\u30ea\u30ac\u30fc\u30bc\u8907\u5408\u4f53CRL4\u306e\u57fa\u8cea\u8a8d\u8b58\u53d7\u5bb9\u4f53\u3067\u3042\u308bDCAF\uff08DDB1- and CUL4-associated factor\uff09\u30d5\u30a1\u30df\u30ea\u30fc\u3092\u6a19\u7684\u3068\u3057\u3001\u30cd\u30aa\u57fa\u8cea\u306e\u5206\u89e3\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002DCAF\u306f\u30d2\u30c8\u30b2\u30ce\u30e0\u306b60\u301c65\u7a2e\u985e\u5b58\u5728\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u591a\u304f\u306f\u57fa\u8cea\u3084\u6a5f\u80fd\u304c\u672a\u89e3\u660e\u3067\u3059\u3002DCAF\u306e\u6a5f\u80fd\u89e3\u6790\u306fCRL4\u304c\u95a2\u4e0e\u3059\u308b\u751f\u547d\u73fe\u8c61\u306e\u7406\u89e3\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u85ac\u306e\u5fdc\u7528\u306b\u91cd\u8981\u3067\u3042\u308a\u3001\u79c1\u305f\u3061\u306f\u57fa\u8cea\u63a2\u7d22\u3084\u6a5f\u80fd\u89e3\u6790\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n      <\/ul>\n    <\/article>\n\n\n<figure class=\"wp-block-image size-large is-resized\" style=\" padding: 40px 0px 40px 40px;\">\n   <img decoding=\"async\" src=\"https:\/\/www.pros.ehime-u.ac.jp\/Interactome\/wp-content\/uploads\/2026\/03\/HP-\u56f32-10-scaled.png\" \n      alt=\"DCAF\u30d5\u30a1\u30df\u30ea\u30fc\" \n      style=\"width:860px; height:auto; display:block;\"\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>  \n\n\n<article class=\"research-item2-2\">\n      <h4 class=\"subhead\">\u2461\t\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u8a98\u5c0e\u85ac(\u5206\u5b50)\u306e\u63a2\u7d22\u3068\u958b\u767a<\/h4>\n      <ul>\n        <p>\u73fe\u5728\u3001\u5b9f\u7528\u5316\u3055\u308c\u3066\u3044\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u85ac\u306e\u591a\u304f\u306fCRBN\u3092E3\u30ea\u30ac\u30fc\u30bc\u3068\u3057\u3066\u5229\u7528\u3057\u3066\u304a\u308a\u3001\u5229\u7528\u53ef\u80fd\u306aE3\u30ea\u30ac\u30fc\u30bc\u304c\u9650\u5b9a\u7684\u3067\u3042\u308b\u3053\u3068\u304c\u8ab2\u984c\u3067\u3059\u3002\u79c1\u305f\u3061\u306fDCAF\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u6ce8\u76ee\u3057\u3001CRBN\u306b\u4ee3\u308f\u308b\u65b0\u305f\u306aDCAF\u3092\u7528\u3044\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u85ac\u306e\u958b\u767a\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n        \n\t  <\/ul>\n    <\/article>\n\n <div style=\"height:40px\" aria-hidden=\"true\" class=\"block-spacer\"><\/div>\n<hr>\n\n\n\n<div style=\"height:80px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<hr>\n\n<br>\n\n    <div class=\"section-title\" id=\"core-tech\">\n     <div style=\"text-align:center; margin:20px 0 60px 0;\">\n <h1>\u57fa\u76e4\u3068\u306a\u308b\u6280\u8853<\/h1>\n  <article class=\"core-tech\">\n      <h4 class=\"subhead\">\u30bf\u30f3\u30d1\u30af\u8cea\u2013\u30bf\u30f3\u30d1\u30af\u8cea\u9593\u76f8\u4e92\u4f5c\u7528\u89e3\u6790 \n<br>(Protein\u2013Protein Interactions\/PPIsAnalysis)<\/h4>\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"block-spacer\"><\/div>  \n\n\n  <div style=\"text-align:left; margin:20px 0;\">\n\n      <ul>\n        \u7d30\u80de\u5185\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u591a\u304f\u306e\u5834\u5408\u3001\u4ed6\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3053\u3068\u3067\u6a5f\u80fd\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u76f8\u4e92\u4f5c\u7528\u89e3\u6790\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6a5f\u80fd\u7406\u89e3\u306b\u4e0d\u53ef\u6b20\u3067\u3042\u308a\u3001\u79c1\u305f\u3061\u306fPPIs\u89e3\u6790\u3092\u57fa\u76e4\u6280\u8853\u3068\u3057\u3066\u3001\u89e3\u6790\u5bfe\u8c61\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30a4\u30f3\u30bf\u30e9\u30af\u30c8\u30fc\u30e0\u89e3\u660e\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\n      <\/ul>\n    <\/article>\n\n <div style=\"height:50px\" aria-hidden=\"true\" class=\"block-spacer\"><\/div>  \n\n<div class=\"section-title\" id=\"core-tech\">\n  <div style=\"text-align:left; margin:20px 0;\">\n<article class=\"core-tech\">\n      <h4 class=\"subhead\">\u2460\t\u7d44\u63db\u3048\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7528\u3044\u305f\u76f8\u4e92\u4f5c\u7528\u89e3\u6790<\/h4>\n      <ul>\n        <p>\u611b\u5a9b\u5927\u5b66\u30d7\u30ed\u30c6\u30aa\u30b5\u30a4\u30a8\u30f3\u30b9\u30bb\u30f3\u30bf\u30fc\uff08PROS\uff09\u3067\u72ec\u81ea\u958b\u767a\u3055\u308c\u305f\u30b3\u30e0\u30ae\u7121\u7d30\u80de\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u7cfb\u306b\u3088\u308a\u30012\u4e07\u7a2e\u985e\u4ee5\u4e0a\u306e\u30d2\u30c8\u7d44\u63db\u3048\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u642d\u8f09\u3057\u305f\u30d7\u30ed\u30c6\u30a4\u30f3\u30a2\u30ec\u30a4\u304c\u69cb\u7bc9\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306bAlphaScreen\u6280\u8853\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u9ad8\u611f\u5ea6\u304b\u3064\u30cf\u30a4\u30b9\u30eb\u30fc\u30d7\u30c3\u30c8\u306aPPIs\u89e3\u6790\u304c\u53ef\u80fd\u3067\u3059\u3002\u672c\u7814\u7a76\u5ba4\u3067\u306f\u3001\u3053\u306e\u6280\u8853\u3092\u6d3b\u7528\u3057\u3001\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u50ac\u5947\u6027\u306b\u95a2\u4e0e\u3059\u308b\u30cd\u30aa\u57fa\u8cea\u540c\u5b9a\u3084\u65b0\u898f\u8a98\u5c0e\u4f53\u306e\u958b\u767a\u306b\u6210\u529f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n      <\/ul>\n    <\/article>\n<figure class=\"wp-block-image size-large is-resized\" style=\" padding: 40px 0px 40px 40px;\">\n   <img decoding=\"async\" src=\"https:\/\/www.pros.ehime-u.ac.jp\/Interactome\/wp-content\/uploads\/2026\/03\/HP-\u56f32-11-scaled.png\" \n      alt=\"alpha-screen\" \n      style=\"width:860px; height:auto; display:block;\"\n <div style=\"height:50px\" aria-hidden=\"true\" class=\"block-spacer\"><\/div>  \n\n<article class=\"core-tech\">\n <div style=\"text-align:left; margin:20px 0;\">\n      <h4 class=\"subhead\">\u2461\t\u8fd1\u63a5\u6a19\u8b58\u6cd5\u3092\u7528\u3044\u305f\u76f8\u4e92\u4f5c\u7528\u89e3\u6790<\/h4>\n     \n<ul>\n        <p>\u7d30\u80de\u5185\u3067\u306e\u8907\u96d1\u306a\u76f8\u4e92\u4f5c\u7528\u3084\u7ffb\u8a33\u5f8c\u4fee\u98fe\u304c\u5fc5\u8981\u306a\u5834\u5408\u3001\u7d44\u63db\u3048\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3088\u308b\u89e3\u6790\u306f\u96e3\u3057\u3044\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u8fd1\u63a5\u6a19\u8b58\u6cd5\uff08Proximity Labeling\uff1aPL\uff09\u306f\u3001\u751f\u7d30\u80de\u5185\u3067\u89e3\u6790\u5bfe\u8c61\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5468\u8fba\u76f8\u4e92\u4f5c\u7528\u3092\u89e3\u6790\u3067\u304d\u308b\u6280\u8853\u3067\u3059\u3002\u79c1\u305f\u3061\u306f\u9ad8\u6d3b\u6027\u306a\u65b0\u898fBioID\u9175\u7d20\u300cAirID\u300d\u3092\u958b\u767a\u3057\u3001E3\u30ea\u30ac\u30fc\u30bc\u306b\u878d\u5408\u3059\u308b\u3053\u3068\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u85ac\u4f9d\u5b58\u7684\u306a\u76f8\u4e92\u4f5c\u7528\u89e3\u6790\u6cd5\u3092\u78ba\u7acb\u3057\u307e\u3057\u305f\u3002<\/li>\n      <\/p>\n    <\/article>\n\t \n\n\n<figure class=\"wp-block-image size-large is-resized\" style=\" padding: 40px 0px 40px 40px;\">\n   <img decoding=\"async\" src=\"https:\/\/www.pros.ehime-u.ac.jp\/Interactome\/wp-content\/uploads\/2026\/03\/HP-\u56f32-12-scaled.png\" \n      alt=\"AirID-DCAF\" \n      style=\"width:860px; height:auto; display:block;\"\n\n\n <div style=\"height:50px\" aria-hidden=\"true\" class=\"block-spacer\"><\/div>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<hr>\t \n<br>\n    <div class=\"section-title\">\n      <h4>\u53c2\u8003\u6587\u732e<\/h4>\n      <p style=\"text-align:left; margin:40px 0 40px 80px;\">References<\/p>\n    <\/div>\n\n      <div class=\"section-title\" id=\"Refarences\">\n     <div style=\"text-align:left; margin:40px 0 40px 40px;\">\n      <ol>\n\t\t  <li>Ito, T. et al. Science 327, 1345\u20131350 (2010).<\/li>\n\t\t  <li>Kr\u00f6nke, J. et al. Science 343, 301\u2013305 (2014).<\/li>\n\t\t  <li>Kr\u00f6nke, J. et al. Nature 523, 183\u2013188 (2015).<\/li>\n\t\t  <li>Lai, A.C.,&#8221;\uff06&#8221; Crews, C. M. Nat. Rev. Drug Discov. 16, 101\u2013114 (2017).<\/li>\n\t\t  <li>Sakamoto, K.M. et al. Proc. Natl. Acad. Sci. U.S.A. 17, 8554\u20138559 (2001).<\/li>\n\t\t  <li>Yamanaka, S. et al. EMBO J. 40, e105375 (2021).<\/li>\n\t\t  <li>Furihata, H. et al. Nat.Commun.11, 4578 (2020).<\/li>\n\t\t  <li>Yamanaka, S. et al. Nat.Commun. 14, 4683, (2023).<\/li>\n\t\t  <li>Sawasaki, T. et al. Proc. Natl. Acad. Sci. U.S.A. 99, 14652\u201314657 (2002).<\/li>\n\t\t  <li>Kido, K. et al. eLife 9, e54983 (2020)<\/li>\n\t\t  <li>Yamanaka, S. et al. Nat. Commun. 13, 183 (2022).<\/li>\n      <\/ol>\n    <\/div>\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"block-spacer\"><\/div>\n\n\n\n<div style=\"max-width: 800px; margin: 0 auto; display: flex; justify-content: left; flex-wrap: wrap; gap: 10px;\">\n\n  <div class=\"wp-block-button\">\n    <a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.pros.ehime-u.ac.jp\/Interactome\/\">\n      HOME\n    <\/a>\n  <\/div>\n\n\n\n<div class=\"container\">\n    <div class=\"foot\">\n      <div>\u00a9 <span id=\"year\"><\/span> YAMANAKALAB powerd By KONISHI<\/div>\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>1. \u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u85ac\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76 \u5f93\u6765\u306e\u4f4e\u5206\u5b50\u533b\u85ac\u54c1\u306f\u3001\u7d30\u80de\u5185\u3067\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u9175\u7d20\u6d3b\u6027\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u4f5c\u7528\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u8fd1\u5e74\u3001\u4f4e\u5206\u5b50\u5316\u5408\u7269\u304c\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5206\u89e3\u3092\u8a98\u5c0e\u3057\u3066\u4f5c\u7528\u3059\u308b\u4f8b\u304c\u660e\u3089\u304b\u3068\u306a\u308a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":101,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"class_list":["post-857","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pros.ehime-u.ac.jp\/Interactome\/wp-json\/wp\/v2\/pages\/857","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pros.ehime-u.ac.jp\/Interactome\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pros.ehime-u.ac.jp\/Interactome\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pros.ehime-u.ac.jp\/Interactome\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pros.ehime-u.ac.jp\/Interactome\/wp-json\/wp\/v2\/comments?post=857"}],"version-history":[{"count":101,"href":"https:\/\/www.pros.ehime-u.ac.jp\/Interactome\/wp-json\/wp\/v2\/pages\/857\/revisions"}],"predecessor-version":[{"id":1169,"href":"https:\/\/www.pros.ehime-u.ac.jp\/Interactome\/wp-json\/wp\/v2\/pages\/857\/revisions\/1169"}],"up":[{"embeddable":true,"href":"https:\/\/www.pros.ehime-u.ac.jp\/Interactome\/wp-json\/wp\/v2\/pages\/101"}],"wp:attachment":[{"href":"https:\/\/www.pros.ehime-u.ac.jp\/Interactome\/wp-json\/wp\/v2\/media?parent=857"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}